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Uganda

Dysregulation of the haem-haemopexin axis is associated with severe malaria in a case–control study of Ugandan children

December 29, 2015 - 15:25 -- Open Access
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Author(s): 
Robyn Elphinstone, Frank Riley, Kevin Kain, et al.
Reference: 
Malaria Journal 2015, 14:511 (21 December 2015)

These data indicate that plasma levels of haemin and haemopexin measured at presentation correlate with malaria severity and levels of haemin and cell-free haemoglobin predict outcome in paediatric severe malaria.

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Introducing rapid diagnostic tests for malaria into registered drug shops in Uganda: lessons learned and policy implications

November 18, 2015 - 14:07 -- Open Access
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Author(s): 
Anthony Mbonye, Sîan Clarke, Sham Lal, Clare Chandler, Eleanor Hutchinson, Kristian Hansen, Pascal Magnussen
Reference: 
Malaria Journal 2015, 14:448 (14 November 2015)

Introducing RDTs into drug shops was feasible and it increased appropriate treatment of malaria with artemisinin-based combination therapy.

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Caregivers’ treatment-seeking behaviors and practices in Uganda—A systematic review (Part II)

November 10, 2015 - 05:25 -- Open Access
Author(s): 
Rosemin Kassam, John B. Collins, Eric Liow, Nabeela Rasool
Reference: 
Acta Tropica, Volume 152, December 2015, Pages 269–281

Prompt treatment with artemisinin combination therapies (ACTs) remains the cornerstone for managing uncomplicated malaria caused by Plasmodium falciparum.

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Narrative review of current context of malaria and management strategies in Uganda (Part I)

November 10, 2015 - 05:24 -- Open Access
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Author(s): 
Rosemin Kassam, John B. Collins, Eric Liow, Nabeela Rasool
Reference: 
Acta Tropica, Volume 152, December 2015, Pages 252–268

In accordance with international targets, the Uganda National Malaria Control Strategic Plan established specific targets to be achieved by 2010.

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Associations between urbanicity and malaria at local scales in Uganda

September 30, 2015 - 16:52 -- Open Access
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Author(s): 
Simon Kigozi, Deepa Pindolia, Andrew Tatem, et al.
Reference: 
Malaria Journal 2015, 14:374 (29 September 2015)

Urbanicity has been shown previously to lead to a reduction in malaria transmission at large spatial scales.

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Lack of effect of intermittent preventive treatment for malaria in pregnancy and intense drug resistance in western Uganda

September 30, 2015 - 16:48 -- Open Access
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Author(s): 
Vera Braun, Eva Rempis, Frank Mockenhaupt, et al.
Reference: 
Malaria Journal 2015, 14:372 (26 September 2015)

In Fort Portal, Uganda, reported use of IPTp with SP does not provide an observable benefit. The molecular markers of P. falciparum indicate high grade SP resistance reaching the threshold set by WHO for the discontinuation of IPTp with SP.

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Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children

September 28, 2015 - 16:48 -- Open Access
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Author(s): 
Kerstin Sundell, Prasanna Jagannathan, Liusheng Huang, Victor Bigira, James Kapisi, Mary Kakuru, Rada Savic, Moses Kamya, Grant Dorsey, Francesca Aweeka
Reference: 
Malaria Journal 2015, 14:368 (24 September 2015)

The protective efficacy of DHA/PQ chemoprevention in young children was strongly associated with higher drug exposure; in children with the highest PQ exposure, monthly DHA/PQ chemoprevention was nearly 100 % protective against malaria.

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Frequency of RANTES gene polymorphisms and their association with incidence of malaria: a longitudinal study on children in Iganga district, Uganda

September 7, 2015 - 11:22 -- Open Access
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Author(s): 
Catherine Lwanira, Mark Mukasa, Göte Swedberg, Fred Kironde
Reference: 
Malaria Journal 2015, 14:341 (5 September 2015)

This study showed that the −403A mutation occurs in nearly half of the study population and the In1.1C allele occurs in one in every four children.

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Anti-malarial prescription practices among children admitted to six public hospitals in Uganda from 2011 to 2013

August 31, 2015 - 15:59 -- Open Access
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Author(s): 
Asadu Sserwanga, David Sears, Arthur Mpimbaza, et al.
Reference: 
Malaria Journal 2015, 14:331 (27 August 2015)

Despite high testing rates for malaria at all sites, prescription of anti-malarials to patients with negative test results remained high, with the exception of one site where a steady decline occurred.

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Association between HRP–2/pLDH rapid diagnostic test band positivity and malaria–related anemia at a peripheral health facility in Western Uganda

July 27, 2015 - 18:27 -- Open Access
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Author(s): 
Ross Boyce, Raquel Reyes, Moses Ntaro, Edgar Mulogo, Michael Matte, Yap Boum II, Mark J. Siedner
Reference: 
JOGH 2015; 5: 020402 (7 pages)

The detection of severe malaria in resource–constrained settings is often difficult because of requirements for laboratory infrastructure and/or clinical expertise.

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