Enhanced support is needed to improve RDT adoption at lower level clinics that focuses on empowering providers to successfully manage non-severe, non-malaria paediatric fevers without referral.
We observed a progressive attenuation of the Vδ2 response only among children incurring high rates of malaria. Unresponsive Vδ2 T cells were marked by expression of CD16, which was elevated in the setting of high malaria transmission.
Adherence to malaria treatment guidelines in Uganda is sub-optimal.
This study shows that despite frequent active screening and prompt treatment of MiP, impaired growth and an increased risk of malaria and non-malaria infections can be observed in the infants.
Plasmodium falciparum infection remains high in rural Uganda.
These results confirm that severe malaria is associated with endothelial activation, and suggest that endothelial activation contributes to microvascular thrombosis and endothelial damage.
This study presents the first geostatistical risk map for M. perstans in Uganda.
A multitude of interplaying factors encouraged consistent LLIN use in this setting.
The study found high provider adherence to RDT results, but that providers believed in certain clinical exceptions and felt they lacked alternative options.
Malaria prevalence estimates varied with diagnostic test, age, and transmission intensity.