Northern Uganda hosts a large population of refugees from South Sudan, and malaria is one of the major health problems in the area.
Deficiencies of equipment, supplies and training exist even in public health facilities.
There is sustained local transmission of parasites with the dhfr I164L mutation in Rukungiri and no evidence to indicate its occurrence is associated with recent travel to highly resistant neighbouring areas.
The PRIME intervention did not have the desired impact on inappropriate treatment of malaria for children under five.
Our findings suggest that households have significant mis-perceptions about malaria likelihood that may contribute to the under-treatment of malaria.
Although infections with only the mutant pfmdr1 86Y genotype were associated with symptomatic infection, this association could primarily be explained by greater parasite densities and therefore greater prevalence of mixed infections in symptomatic children.
The study observed high but geographically and demographically heterogenous patterns of asymptomatic malaria prevalence among children living in northern Uganda.
Avidity to two different P. falciparum antigens was lower in areas of high transmission intensity compared to areas with lower transmission.
Mutations in pfkelch13 and the six background genes may not play an important role in the in vivo selection after artemether–lumefantrine treatment in Uganda.
The study results show that IRS was associated with a significant reduction in malaria morbidity in northern Uganda in the first 3 months following IRS.