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Uganda

Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda

November 26, 2009 - 11:15 -- Ingeborg van Schayk
Author(s): 
Patrick M Newman, Humphrey Wanzira, Gabriel Tumwine, Emmanuel Arinaitwe, Sarah Waldman, Jane Achan, Diane Havlir, Philip J Rosenthal, Grant Dorsey, Tamara D Clark, Deborah Cohan
Reference: 
Malaria Journal 2009, 8:254 (14 November 2009)

This was a cross sectional study comparing the prevalence of placental malaria between HIV-infected women prescribed TS and HIV-uninfected women prescribed intermittent preventive therapy with sulphadoxine-pyrimethamine (IPT-SP) in a high malaria transmission area in Uganda.

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Intermittent preventive treatment of malaria in pregnancy (IPTp): participation of community-directed distributors of ivermectin for onchocerciasis improves IPTp access in Ugandan rural communities

November 26, 2009 - 06:58 -- Kabogo Ndegwa
Tags: 
Author(s): 
Richard Ndyomugyenyi, Ephraim Tukesiga, James Katamanywa
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1221-1228, doi:10.1016/j.trstmh.2009.03.006

Access and compliance to sulfadoxine–pyrimethamine (SP) for intermittent preventive treatment of malaria in pregnancy (IPTp) when delivered by community-directed drug distributors (CDDs) of ivermectin for onchocerciasis control (intervention arm) and through delivery of SP–IPTp during antenatal care visit (control arm) was investigated in western Uganda.

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Artemether Lumefantrine versus Dihydroartemisinin Piperaquine for Falciparum Malaria: A Longitudinal, Randomized Trial in Young Ugandan Children

November 16, 2009 - 14:04 -- Ingeborg van Schayk
Author(s): 
Emmanuel Arinaitwe, Taylor G. Sandison, Humphrey Wanzira, Abel Kakuru, Jaco Homsy, Julius Kalamya, Moses R. Kamya, Neil Vora, Bryan Greenhouse, Philip J. Rosenthal, Jordan Tappero, and Grant Dorsey
Reference: 
Clinical Infectious Diseases 2009; Volume 49, Number 11: Pages 1629–1637, DOI: 10.1086/647946

Artemisinin-based combination therapies are now widely recommended as first-line treatment for uncomplicated malaria. However, which therapies are optimal is a matter of debate. We aimed to compare the short- and longer-term efficacy of 2 leading therapies in a cohort of young Ugandan children.

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Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial

October 29, 2009 - 12:18 -- Ingeborg van Schayk
Author(s): 
Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial Victoria Nakibuuka, Grace Ndeezi, Deborah Nakiboneka, Christopher M Ndugwa, James K Tumwine
Reference: 
Malaria Journal 2009, 8:237 (24 October 2009)

Malaria carries high case fatality among children with sickle cell anaemia. In Uganda, chloroquine is used for prophylaxis in these children despite unacceptably high levels of resistance. Intermittent presumptive treatment with sulphadoxine-pyrimethamine (SP) has shown great potential for reducing prevalence of malaria and anaemia among pregnant women and infants.

Presumptive treatment with SP was more efficacious than weekly chloroquine in reducing prevalence of malaria in children with sickle cell anaemia. Continued use of chloroquine for malaria chemoprophylaxis in children with sickle cell anaemia in Uganda does not seem to be justified. ClinicalTrials.gov Identifier: NCTOO124267

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Insecticide resistance and its association with target-site mutations in natural populations of Anopheles gambiae from eastern Uganda

October 25, 2009 - 17:27 -- Bart G.J. Knols
Author(s): 
Urvashi Ramphul, Thomas Boase, Chris Bass, Loyce M. Okedi, Martin J. Donnelly, Pie Müller
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 11, November 2009, Pages 1121-1126, doi:10.1016/j.trstmh.2009.02.014

Insecticide resistance in Anopheles gambiae threatens the success of malaria vector control programmes in sub-Saharan Africa. In order to manage insecticide resistance successfully, it is essential to assess continuously the target mosquito population. Here, we collected baseline information on the distribution and prevalence of insecticide resistance and its association with target-site mutations in eastern Uganda.

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