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Uganda

Intermittent preventive treatment of malaria delivered to primary schoolchildren provided effective individual protection in Jinja, Uganda: secondary outcomes of a cluster-randomized trial (START-IPT)

September 23, 2019 - 14:39 -- Open Access
Author(s): 
Andrea M. Rehman, Catherine Maiteki-Sebuguzi, Samuel Gonahasa, Jaffer Okiring, Simon P. Kigozi, Clare I. R. Chandler, Chris Drakeley, Grant Dorsey, Moses R. Kamya and Sarah G. Staedke
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Malaria Journal 2019 18:318, 18 September 2019

Intermittent preventive treatment (IPT) of malaria is recommended as policy for certain high-risk populations, but not currently for schoolchildren. A cluster-randomized trial was conducted to evaluate the effect of IPT with dihydroartemisinin–piperaquine (DP) on primary schoolchildren in Jinja, Uganda. Results of the impact of IPT of schoolchildren on community-level transmission have been reported previously. Here, secondary outcomes from a school-based survey are presented.

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Is that a real oocyst? Insectary establishment and identification of Plasmodium falciparum oocysts in midguts of Anopheles mosquitoes fed on infected human blood in Tororo, Uganda

September 3, 2019 - 15:09 -- Open Access
Author(s): 
Alex K. Musiime, Joseph Okoth, Chiara Andolina, et al.
Reference: 
Malaria Journal 2019 18:287, 27 August 2019

The human infectious reservoir for malaria consists of individuals capable of infecting mosquitoes. Oocyst prevalence and density are typical indicators of human infectivity to mosquitoes. However, identification of oocysts is challenging, particularly in areas of low malaria transmission intensity where few individuals may infect mosquitoes, and infected mosquitoes tend to have few oocysts. Here, features that differentiate oocysts from other oocyst-like in mosquito midguts are explained and illustrated. In addition, the establishment and maintenance of infrastructure to perform malaria transmission experiments is described. This work may support other initiatives to set up membrane feeding infrastructure and guide oocyst detection in low transmission settings.

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Implementing population-based mass drug administration for malaria: experience from a high transmission setting in North Eastern Uganda

August 13, 2019 - 15:41 -- Open Access
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Author(s): 
Ronald Mulebeke, Humphrey Wanzira, Fred Bukenya, Thomas Eganyu, Kathryn Collborn, Richard Elliot, Jean-Pierre Van Geertruyden, Dorothy Echodu and Adoke Yeka
Reference: 
Malaria Journal 2019 18:271, 9 August 2019

Mass drug administration (MDA) is a suggested mean to accelerate efforts towards elimination and attainment of malaria-free status. There is limited evidence of suitable methods of implementing MDA programme to achieve a high coverage and compliance in low-income countries. The objective of this paper is to assess the impact of this MDA delivery strategy while using coverage measured as effective population in the community and population available.

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Factors associated with uptake of optimal doses of intermittent preventive treatment for malaria among pregnant women in Uganda: analysis of data from the Uganda Demographic and Health Survey, 2016

July 29, 2019 - 15:54 -- Open Access
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Author(s): 
Denis Okethwangu, Jimmy Opigo, Stella Atugonza, Catherine T. Kizza, Monica Nabatanzi, Claire Biribawa, Daniel Kyabayinze and Alex R. Ario
Reference: 
Malaria Journal 2019 18:250, 26 July 2019

The Uganda National Malaria Control Programme recognizes the importance of minimizing the effect of malaria among pregnant women. Accordingly, strategies including intermittent preventive treatment of malaria in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP) have been scaled up. Uptake of IPTp-SP among pregnant women in Uganda, aged 15–49 years who had had a live birth 2 years preceding the 2016 Uganda Demographic and Health Survey (UDHS) was determined and factors associated with the uptake of optimal IPTp-SP doses were identified.

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Social norms, misperceptions, and mosquito net use: a population-based, cross-sectional study in rural Uganda

June 7, 2019 - 16:55 -- Open Access
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Author(s): 
Jessica M. Perkins, Paul Krezanoski, Sae Takada, Bernard Kakuhikire, Vincent Batwala, Alexander C. Tsai, Nicholas A. Christakis and David R. Bangsberg
Reference: 
Malaria Journal 2019 18:189, 3 June 2019

Mosquito net use is an essential part of malaria prevention. Although previous research has shown that many people sleep under a mosquito net in endemic areas, it is unknown whether people underestimate how common it is to sleep under a net every night. Furthermore, perceived social norms about whether most others sleep under a mosquito net every night may contribute to personally sleeping under a net, given decades of research showing that people often mimic others’ behaviours.

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Household and maternal risk factors for malaria in pregnancy in a highly endemic area of Uganda: a prospective cohort study

April 29, 2019 - 13:03 -- Open Access
Author(s): 
Jaffer Okiring, Peter Olwoch, Abel Kakuru, Joseph Okou, Harriet Ochokoru, Tedy Andra Ochieng, Richard Kajubi, Moses R. Kamya, Grant Dorsey and Lucy S. Tusting
Reference: 
Malaria Journal 2019 18:144, 23 April 2019

Malaria in pregnancy is a major public health challenge, but its risk factors remain poorly understood in some settings. This study assessed the association between household and maternal characteristics and malaria among pregnant women in a high transmission area of Uganda.

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Non-invasive surveillance of Plasmodium infection by real-time PCR analysis of ethanol preserved faeces from Ugandan school children with intestinal schistosomiasis

April 4, 2019 - 15:36 -- Open Access
Author(s): 
Hajri Al-Shehri, B. Joanne Power, J. Russell Stothard, et al.
Reference: 
Malaria Journal 2019 18:109, 1 April 2019

In this high transmission setting, EPF sampling with rtPCR analysis has satisfactory diagnostic performance in estimation of mean prevalence and prevalence by school upon direct comparison with POC-RDTs.

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NOT Open Access | Changing Molecular Markers of Antimalarial Drug Sensitivity across Uganda

March 5, 2019 - 15:56 -- NOT Open Access
Author(s): 
Victor Asua, Joanna Vinden, Melissa D. Conrad, Jennifer Legac, Simon P. Kigozi, Moses R. Kamya, Grant Dorsey, Samuel L. Nsobya and Philip J. Rosenthal
Reference: 
Antimicrob. Agents Chemother. February 2019 63:e01818-18

The potential spread of antimalarial drug resistance to Africa, in particular for artemisinins and key partner drugs, is a major concern.

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Caregiver responses and association with delayed care-seeking in children with uncomplicated and severe malaria

January 2, 2019 - 15:21 -- Open Access
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Author(s): 
Arthur Mpimbaza, Anne Katahoire, Philip J. Rosenthal, Charles Karamagi and Grace Ndeezi
Reference: 
Malaria Journal 2018 17:476, 18 December 2018

Caregivers should be educated on the importance of promptly seeking care at a health facility where appropriate care can be provided.

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Community facilitators and barriers to a successful implementation of mass drug administration and indoor residual spraying for malaria prevention in Uganda: a qualitative study

January 2, 2019 - 15:14 -- Open Access
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Author(s): 
Humphrey Wanzira, Susan Naiga, Ronald Mulebeke, Fred Bukenya, Mariam Nabukenya, Osborn Omoding, Dorothy Echodu and Adoke Yeka
Reference: 
Malaria Journal 2018 17:474, 17 December 2018

This study documents important community engagement strategies that need to be considered when implementing malaria MDA in combination with IRS, for malaria prevention in such settings.

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