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No Evidence of Decreased Artemisinin Efficacy in a High-Transmission Malaria Setting in Mali

July 4, 2012 - 14:09 -- Patrick Sampao
Author(s): 
Caroline L. Ng and David A. Fidock
Reference: 
Am J Trop Med Hyg 2012 87:16-17

MalariaWorldOne major threat, however, comes from recent reports of emerging resistance to artemisinins, which was first documented in western Cambodia and more recently in northwestern Thailand.5–8 This region in Southeast Asia is of particular concern because it was the source of CQ and SP resistance that eventually migrated to Africa,9 raising concerns that artemisinin resistance may follow the same trajectory

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B cell analysis of ethnic groups in Mali with differential susceptibility to malaria

May 15, 2012 - 11:44 -- Kabogo Ndegwa
Author(s): 
Portugal S, Doumtabe D, Traore B, Miller LH, Troye-Blomberg M, Doumbo OK, Dolo A, Pierce SK, Crompton PD
Reference: 
Malaria Journal 2012, 11:162 (11 May 2012)

MalariaWorldThese data show that the malaria-resistant Fulani have a higher percentage of activated MBCs compared to the Dogon, and that P. falciparum infection is associated with a higher percentage of plasma cells in the Fulani compared to the Dogon, findings that may account for the higher levels of P. falciparum antibodies in the Fulani.

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Open Access | Changes in the levels of cytokines, chemokines and malaria-specific antibodies in response to Plasmodium falciparum infection in children living in sympatry in Mali

April 11, 2012 - 06:46 -- Kabogo Ndegwa
Author(s): 
Bostrom S, Giusti P, Arama C, Persson J, Dara V, Traore B, Dolo A, Doumbo O, Troye-Blomberg M
Reference: 
Malaria Journal 2012, 11:109 (5 April 2012)

MalariaWorldTaken together, this study demonstrates, in accordance with previous work, that Fulani children mount a stronger inflammatory and antibody response against P. falciparum parasites compared to the Dogon and that these differences are evident already at an early age.

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Open Access | The implementation of malaria intermittent preventive treatment with sulphadoxine-pyrimethamine in infants reduced all-cause mortality in the district of Kolokani, Mali: results from a cluster randomized control trial

March 22, 2012 - 12:53 -- Kabogo Ndegwa
Author(s): 
Dicko A, Konare M, Traore D, Testa J, Salamon R, Doumbo O, Rogier C
Reference: 
Malaria Journal 2012, 11:73 (16 March 2012)

MalariaWorldThe implementation of the IPTi-SP resulted in a substantial reduction in all-cause mortality in children.

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Anopheles gambiae resistance to pyrethroid-treated nets in cotton versus rice areas in Mali

February 15, 2012 - 14:59 -- Patrick Sampao
Author(s): 
Moussa Fane, Ousmane Cissé, Cheick Sékou F. Traore, Philippe Sabatier
Reference: 
Acta Tropica, Volume 122, Issue 1, April 2012, Pages 1-6

MalariaWorldThe objective of this study was to evaluate the efficacy of alpha-cypermethrin treated nets in settings where insecticides are used against pests.

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Open Access | Use of a pLDH-based dipstick in the diagnostic and therapeutic follow-up of malaria patients in Mali

November 29, 2011 - 09:52 -- Kabogo Ndegwa
Author(s): 
Ouattara A, Doumbo S, Saye R, Beavogui AH, Traore B, Djimde A, Niangly A, Kayentao K, Diallo M, Doumbo OK, Thera MA
Reference: 
Malaria Journal 2011, 10:345 (24 November 2011)

MalariaWorldOptiMal-IT test revealed similar results when compared to microscopy which is considered the gold standard for malaria diagnostics.

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Cytokine gene haplotypes with a potential effect on susceptibility to malaria in sympatric ethnic groups in Mali

October 17, 2011 - 10:04 -- Patrick Sampao
Author(s): 
Elisabeth Israelsson, Bakary Maiga, Susannah Kearsley, Amagana Dolo, Manijeh Vafa Homann, Ogobara K. Doumbo, Marita Troye-Blomberg, Per Tornvall, Klavs Berzins
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 7, October 2011, Pages 1608-1615

MalariaWorldWe therefore suggest that the polymorphisms analysed in this study all show a potential to influence the relatively lower susceptibility to malaria seen in the Fulani ethnic group as compared to the other sympatric ethnic groups.

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Open Access | Increase in EPI vaccines coverage after implementation of intermittent preventive treatment of malaria in infant with Sulfadoxine -pyrimethamine in the district of Kolokani, Mali: Results from a cluster randomized control trial

July 19, 2011 - 14:46 -- Patrick Sampao
Author(s): 
Alassane Dicko, Sidy O Toure, Ogobara K Doumbo, et al.
Reference: 
BMC Public Health 2011, 11:573

This study shows that high coverage of the IPTi can be obtained when the strategy is implemented using routine health services and implementation results in a significant increase in coverage of EPI vaccines in the district of Kolokani, Mali.

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Filarial Infection Suppresses Malaria-Specific Multifunctional Th1 and Th17 Responses in Malaria and Filarial Coinfections

April 5, 2011 - 13:10 -- Kabogo Ndegwa
Author(s): 
Simon Metenou, Benoit Dembele, Thomas B. Nutman, et al.
Reference: 
The Journal of Immunology April 15, 2011 vol. 186 no. 8 4725-4733

The mechanisms underlying the modulation of both the malaria-specific immune response and the course of clinical malaria in the context of concomitant helminth infection are poorly understood.

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Open Access | Intermittent Preventive Treatment of Malaria Provides Substantial Protection against Malaria in Children Already Protected by an Insecticide-Treated Bednet in Mali: A Randomised, Double-Blind, Placebo-Controlled Trial

February 4, 2011 - 07:30 -- Kabogo Ndegwa
Author(s): 
Alassane Dicko, Abdoulbaki I. Diallo, Brian Greenwood, et al.
Reference: 
PLoS Med 8(2): e1000407

IPTc given during the malaria transmission season provided substantial protection against clinical episodes of malaria, malaria infection, and anaemia in children using an LLIN.

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