One major threat, however, comes from recent reports of emerging resistance to artemisinins, which was first documented in western Cambodia and more recently in northwestern Thailand.5–8 This region in Southeast Asia is of particular concern because it was the source of CQ and SP resistance that eventually migrated to Africa,9 raising concerns that artemisinin resistance may follow the same trajectory
These data show that the malaria-resistant Fulani have a higher percentage of activated MBCs compared to the Dogon, and that P. falciparum infection is associated with a higher percentage of plasma cells in the Fulani compared to the Dogon, findings that may account for the higher levels of P. falciparum antibodies in the Fulani.
Taken together, this study demonstrates, in accordance with previous work, that Fulani children mount a stronger inflammatory and antibody response against P. falciparum parasites compared to the Dogon and that these differences are evident already at an early age.
The implementation of the IPTi-SP resulted in a substantial reduction in all-cause mortality in children.
The objective of this study was to evaluate the efficacy of alpha-cypermethrin treated nets in settings where insecticides are used against pests.
OptiMal-IT test revealed similar results when compared to microscopy which is considered the gold standard for malaria diagnostics.
We therefore suggest that the polymorphisms analysed in this study all show a potential to influence the relatively lower susceptibility to malaria seen in the Fulani ethnic group as compared to the other sympatric ethnic groups.
This study shows that high coverage of the IPTi can be obtained when the strategy is implemented using routine health services and implementation results in a significant increase in coverage of EPI vaccines in the district of Kolokani, Mali.
The mechanisms underlying the modulation of both the malaria-specific immune response and the course of clinical malaria in the context of concomitant helminth infection are poorly understood.
IPTc given during the malaria transmission season provided substantial protection against clinical episodes of malaria, malaria infection, and anaemia in children using an LLIN.