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B cell analysis of ethnic groups in Mali with differential susceptibility to malaria

May 15, 2012 - 11:44 -- Kabogo Ndegwa
Author(s): 
Portugal S, Doumtabe D, Traore B, Miller LH, Troye-Blomberg M, Doumbo OK, Dolo A, Pierce SK, Crompton PD
Reference: 
Malaria Journal 2012, 11:162 (11 May 2012)

MalariaWorldThese data show that the malaria-resistant Fulani have a higher percentage of activated MBCs compared to the Dogon, and that P. falciparum infection is associated with a higher percentage of plasma cells in the Fulani compared to the Dogon, findings that may account for the higher levels of P. falciparum antibodies in the Fulani.

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Open Access | Changes in the levels of cytokines, chemokines and malaria-specific antibodies in response to Plasmodium falciparum infection in children living in sympatry in Mali

April 11, 2012 - 06:46 -- Kabogo Ndegwa
Author(s): 
Bostrom S, Giusti P, Arama C, Persson J, Dara V, Traore B, Dolo A, Doumbo O, Troye-Blomberg M
Reference: 
Malaria Journal 2012, 11:109 (5 April 2012)

MalariaWorldTaken together, this study demonstrates, in accordance with previous work, that Fulani children mount a stronger inflammatory and antibody response against P. falciparum parasites compared to the Dogon and that these differences are evident already at an early age.

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Open Access | The implementation of malaria intermittent preventive treatment with sulphadoxine-pyrimethamine in infants reduced all-cause mortality in the district of Kolokani, Mali: results from a cluster randomized control trial

March 22, 2012 - 12:53 -- Kabogo Ndegwa
Author(s): 
Dicko A, Konare M, Traore D, Testa J, Salamon R, Doumbo O, Rogier C
Reference: 
Malaria Journal 2012, 11:73 (16 March 2012)

MalariaWorldThe implementation of the IPTi-SP resulted in a substantial reduction in all-cause mortality in children.

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Anopheles gambiae resistance to pyrethroid-treated nets in cotton versus rice areas in Mali

February 15, 2012 - 14:59 -- Patrick Sampao
Author(s): 
Moussa Fane, Ousmane Cissé, Cheick Sékou F. Traore, Philippe Sabatier
Reference: 
Acta Tropica, Volume 122, Issue 1, April 2012, Pages 1-6

MalariaWorldThe objective of this study was to evaluate the efficacy of alpha-cypermethrin treated nets in settings where insecticides are used against pests.

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Open Access | Use of a pLDH-based dipstick in the diagnostic and therapeutic follow-up of malaria patients in Mali

November 29, 2011 - 09:52 -- Kabogo Ndegwa
Author(s): 
Ouattara A, Doumbo S, Saye R, Beavogui AH, Traore B, Djimde A, Niangly A, Kayentao K, Diallo M, Doumbo OK, Thera MA
Reference: 
Malaria Journal 2011, 10:345 (24 November 2011)

MalariaWorldOptiMal-IT test revealed similar results when compared to microscopy which is considered the gold standard for malaria diagnostics.

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Cytokine gene haplotypes with a potential effect on susceptibility to malaria in sympatric ethnic groups in Mali

October 17, 2011 - 10:04 -- Patrick Sampao
Author(s): 
Elisabeth Israelsson, Bakary Maiga, Susannah Kearsley, Amagana Dolo, Manijeh Vafa Homann, Ogobara K. Doumbo, Marita Troye-Blomberg, Per Tornvall, Klavs Berzins
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 7, October 2011, Pages 1608-1615

MalariaWorldWe therefore suggest that the polymorphisms analysed in this study all show a potential to influence the relatively lower susceptibility to malaria seen in the Fulani ethnic group as compared to the other sympatric ethnic groups.

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Open Access | Increase in EPI vaccines coverage after implementation of intermittent preventive treatment of malaria in infant with Sulfadoxine -pyrimethamine in the district of Kolokani, Mali: Results from a cluster randomized control trial

July 19, 2011 - 14:46 -- Patrick Sampao
Author(s): 
Alassane Dicko, Sidy O Toure, Ogobara K Doumbo, et al.
Reference: 
BMC Public Health 2011, 11:573

This study shows that high coverage of the IPTi can be obtained when the strategy is implemented using routine health services and implementation results in a significant increase in coverage of EPI vaccines in the district of Kolokani, Mali.

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Filarial Infection Suppresses Malaria-Specific Multifunctional Th1 and Th17 Responses in Malaria and Filarial Coinfections

April 5, 2011 - 13:10 -- Kabogo Ndegwa
Author(s): 
Simon Metenou, Benoit Dembele, Thomas B. Nutman, et al.
Reference: 
The Journal of Immunology April 15, 2011 vol. 186 no. 8 4725-4733

The mechanisms underlying the modulation of both the malaria-specific immune response and the course of clinical malaria in the context of concomitant helminth infection are poorly understood.

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Open Access | Intermittent Preventive Treatment of Malaria Provides Substantial Protection against Malaria in Children Already Protected by an Insecticide-Treated Bednet in Mali: A Randomised, Double-Blind, Placebo-Controlled Trial

February 4, 2011 - 07:30 -- Kabogo Ndegwa
Author(s): 
Alassane Dicko, Abdoulbaki I. Diallo, Brian Greenwood, et al.
Reference: 
PLoS Med 8(2): e1000407

IPTc given during the malaria transmission season provided substantial protection against clinical episodes of malaria, malaria infection, and anaemia in children using an LLIN.

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Open Access | Lactase persistence genotypes and malaria susceptibility in Fulani of Mali

January 19, 2011 - 06:40 -- Kabogo Ndegwa
Author(s): 
Lokki AI, Jarvela I, Israelsson E, Maiga B, Troye-Blomberg M, Dolo A, Doumbo OK, Meri S, Holmberg V
Reference: 
Malaria Journal 2011, 10:9 (14 January 2011)

Plasmodium falciparum parasitaemia in asymptomatic Fulani is more common in individuals with lactase non-persistence genotypes, but this difference is not statistically significant.

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