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Papua New Guinea

Treatment with Coartem (Artemether-Lumefantrine) in Papua New Guinea

April 13, 2010 - 08:58 -- Patrick Sampao
Author(s): 
Sonja Schoepflin, Enmoore Lin, Benson Kiniboro, Jeana T. DaRe, Rajeev K. Mehlotra, Peter A. Zimmerman, Ivo Mueller, AND Ingrid Felger
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 529-534

After excluding genetic host factors by genotyping potentially relevant cytochrome P450 loci, the high number of treatment failures in our study is best explained by poor adherence to complex dosing regimens in combination with insufficient fat supplementation, which are both crucial parameters for the outcome of Coartem treatment.

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Open Access | Population Hemoglobin Mean and Anemia Prevalence in Papua New Guinea: New Metrics for Defining Malaria Endemicity?

March 5, 2010 - 16:29 -- Ingeborg van Schayk
Author(s): 
Nicolas Senn, Seri Maraga, Albert Sie, Stephen J. Rogerson, John C. Reeder, Peter Siba, Ivo Mueller
Reference: 
PLoS ONE 5(2): e9375

The aim of this study is to compare population hemoglobin mean and anemia prevalence to established indicators of malaria endemicity, including parasite rates, rates of enlarged spleens in children, and records of (presumptive) malaria diagnosis among populations living with different levels of malaria transmission.

In vitro sensitivity of Plasmodium falciparum to conventional and novel antimalarial drugs in Papua New Guinea

February 11, 2010 - 13:36 -- Kabogo Ndegwa
Author(s): 
Rina P. M. Wong, Dulcie Lautu, Livingstone Tavul, Sara L. Hackett, Peter Siba, Harin A. Karunajeewa, Kenneth F. Ilett, Ivo Mueller, Timothy M. E. Davis
Reference: 
Tropical Medicine & International Health, Volume 15, Issue 3, March 2010, Pages: 342-349

To facilitate the monitoring of antimalarial drug resistance in this setting, we assessed the in vitro sensitivity of Plasmodium falciparum isolates from Madang Province.

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Open Access | Naturally-acquired humoral immune responses against the N- and C-termini of the Plasmodium vivax MSP1 protein in endemic regions of Brazil and Papua New Guinea using a multiplex assay

January 29, 2010 - 14:27 -- Ingeborg van Schayk
Author(s): 
Carmen Fernandez-Becerra, Sergi Sanz, Marina Brucet, Danielle I Stanisic, Fabiana P Alves, Erney P Camargo, Pedro L Alonso, Ivo Mueller, Hernando A del Portillo
Reference: 
Malaria Journal 2010, 9:29 (21 January 2010)

This study validates the use of the multiplex assay to measure naturally-acquired IgG antibodies against the merozoite surface protein 1 of P. vivax.

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Open Access | Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance

January 13, 2010 - 13:15 -- Ingeborg van Schayk
Author(s): 
Jutta Marfurt, Thomas A Smith, Ian M Hastings, Ivo Muller, Albert Sie, Olive Oa, Moses Baisor, John C Reeder, Hans-Peter Beck, Blaise Genton
Reference: 
Malaria Journal 2010, 9:8 (7 January 2010)

Interesting paper aiming at investigating the role and applicability of the molecular drug resistance profiles in community samples in Papua New Guinea.

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Vaccines against malaria: Perspectives from Papua New Guinea

October 25, 2009 - 16:21 -- Bart G.J. Knols
Author(s): 
Ivo Mueller, Blaise Genton, Inoni Betuela and Michael P. Alpers
Reference: 
Human Vaccines, Volume 6, Issue 1, January 2010

Despite its small population and isolate location Papua New Guinea (PNG) with a malaria burden comparable to sub-Saharan Africa, its intense transmission of all 4 human Plasmodium species and an unrivalled combination of environmental and human variation offers unique perspectives on malaria vaccines.

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