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Papua New Guinea

Open Access | Filarial Worms Reduce Plasmodium Infectivity in Mosquitoes

March 1, 2011 - 06:43 -- Kabogo Ndegwa
Author(s): 
Matthew T. Aliota, Cheng-Chen Chen, Henry Dagoro, Jeremy F. Fuchs, Bruce M. Christensen
Reference: 
PLoS Negl Trop Dis 5(2): e963

These results could have an impact on vector infection and transmission dynamics in areas where Anopheles transmit both parasites, i.e., the elimination of filarial worms in a co-endemic locale could enhance malaria transmission.

Molecular Assessment of Plasmodium falciparum Resistance to Antimalarial Drugs in Papua New Guinea Using an Extended Ligase Detection Reaction Fluorescent Microsphere Assay

January 24, 2011 - 11:11 -- Kabogo Ndegwa
Author(s): 
Rina P. M. Wong, Harin Karunajeewa, Ivo Mueller, Peter Siba, Peter A. Zimmerman, and Timothy M. E. Davis
Reference: 
Antimicrobial Agents and Chemotherapy, February 2011, p. 798-805, Vol. 55, No. 2

Surveillance for Plasmodium falciparum drug resistance mutations is becoming an established tool for assessing antimalarial treatment effectiveness.

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High Throughput Multiplex Assay for Species Identification of Papua New Guinea Malaria Vectors: Members of the Anopheles punctulatus (Diptera: Culicidae) Species Group

January 7, 2011 - 12:15 -- Patrick Sampao
Author(s): 
Cara N. Henry-Halldin., Lisa Reimer, Edward Thomsen.,Peter A. Zimmerman., et al
Reference: 
Am J Trop Med Hyg, Jan 2011; 84: 166 - 173.

We developed a multiplex polymerase chain reaction (PCR)–based assay specific for known species-specific nucleotide differences in the internal transcribed spacer 2 region and identified the five species most frequently implicated in transmitting disease (An. punctulatus, An. koliensis, An. farauti 1, An. hinesorum, and An. farauti 4).

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Open Access | Incomplete concerted evolution and reproductive isolation at the rDNA locus uncovers nine cryptic species within Anopheles longirostris from Papua New Guinea

December 28, 2010 - 13:16 -- Patrick Sampao
Author(s): 
David E Alquezar, Stephane Hemmerter , Robert D Cooper and Nigel W Beebe
Reference: 
BMC Evolutionary Biology 2010

Here we follow the evolution of the rDNA second internal transcribed spacer (ITS2) and the mitochondrial DNA cytochrome oxidase I subunit in the malaria mosquito Anopheles longirostris from Papua New Guinea (PNG).

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Open Access | Community response to intermittent preventive treatment of malaria in infants (IPTi) in Papua New Guinea

December 23, 2010 - 14:00 -- Kabogo Ndegwa
Author(s): 
Pell C, Straus L, Phuanukoonnon S, Lupiwa S, Mueller I, Senn N, Siba P, Gysels M, Pool R
Reference: 
Malaria Journal 2010, 9:369 (22 December 2010)

The degree of similarity between findings from the acceptability studies undertaken in sub-Saharan Africa and PNG allows some generalization relating to the implementation of IPTi outside of Africa:

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Open Access | Comparison of diagnostic methods for the detection and quantification of the four sympatric Plasmodium species in field samples from Papua New Guinea

December 16, 2010 - 09:01 -- Kabogo Ndegwa
Author(s): 
Rosanas-Urgell A, Mueller D, Betuela I, Barnadas C, Iga J, Zimmerman PA, del Portillo HA, Siba P, Mueller I, Felger I
Reference: 
Malaria Journal 2010, 9:361 (14 December 2010)

The qPCR assay developed proved optimal for detection of all four Plasmodium species.

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Brief Report: Pyrethroid Susceptibility in Natural Populations of the Anopheles punctulatus Group (Diptera: Culicidae) in Papua New Guinea

December 3, 2010 - 08:06 -- Patrick Sampao
Author(s): 
John B. Keven, Cara N. Henry-Halldin, Edward K. Thomsen, Ivo Mueller, Peter M. Siba, Peter A. Zimmerman, AND Lisa J. Reimer
Reference: 
Am J Trop Med Hyg, Dec 2010; 83: 1259 - 1261.

The study used World Health Organization standard susceptibility bioassays to detect knockdown phenotypes and a novel nested polymerase chain reaction to detect the knockdown resistant (kdr) allele in these vectors.

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Open Access | Multilocus haplotypes reveal variable levels of diversity and population structure of Plasmodium falciparum in Papua New Guinea, a region of intense perennial transmission

November 26, 2010 - 10:02 -- Kabogo Ndegwa
Author(s): 
Schultz L, Wapling J, Mueller I, Ntsuke PO, Senn N, Nale J, Kiniboro B, Buckee CO, Tavul L, Siba PM, Reeder JC, Barry AE
Reference: 
Malaria Journal 2010, 9:336 (23 November 2010)

The observed population genetics of P. falciparum in this region is likely to be a consequence of the high transmission intensity combined with the isolation of human and vector populations, especially those located inland and migration of parasites via human movement into coastal populations.

Open Access | Seeking treatment for symptomatic malaria in Papua New Guinea

October 11, 2010 - 07:57 -- Kabogo Ndegwa
Author(s): 
Davy CP, Sicuri E, Ome M, Lawrence-Wood E, Siba P, Wavi G, Mueller I, Conteh L
Reference: 
Malaria Journal 2010, 9:268 (6 October 2010)

Simply bringing health services closer to where people live may not always result in a greater use of formal health care facilities.

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Immunology: Robert Koch redux: malaria immunology in Papua New Guinea

July 20, 2010 - 07:27 -- Kabogo Ndegwa
Author(s): 
DI Stanisic, I Mueller, I Betuela, P Siba, L Schofield
Reference: 
Parasite Immunology, Volume 32, Issue 8 (p 623-632)

Over a century ago, the malaria expedition of the brilliant microbiologist Robert Koch to the Dutch East Indies (Indonesia) and German New Guinea (now Papua New Guinea, or PNG), resulted in profound observations that are still central to our current understanding of the epidemiology and acquisition of immunity to the malaria parasite Plasmodium.

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