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Colombian

Randomized, Prospective, Three-Arm Study to Confirm the Auditory Safety and Efficacy of Artemether-Lumefantrine in Colombian Patients with Uncomplicated Plasmodium falciparum Malaria

January 11, 2012 - 08:20 -- Patrick Sampao
Author(s): 
Gabriel Carrasquilla, Clemencia Barón, Edwin M. Monsell, Marc Cousin, Verena Walter, Gilbert Lefèvre, Oliver Sander and Laurel M. Fisher
Reference: 
Am J Trop Med Hyg 2012 86:75-83

MalariaWorldThe safety of artemether-lumefantrine in patients with acute, uncomplicated Plasmodium falciparum malaria was investigated prospectively using the auditory brainstem response (ABR) and pure-tone thresholds.

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Short Communication: Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates

March 1, 2011 - 08:01 -- Patrick Sampao
Author(s): 
Diego Garzón-Ospina, Liza Romero-Murillo, Luisa F. Tobón, Manuel A. Patarroyo
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 2, March 2011, Pages 528-531

Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity.

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