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The effect of immunization schedule with the malaria vaccine candidate RTS,S/AS01E on protective efficacy and anti-circumsporozoite protein antibody avidity in African infants

March 10, 2015 - 13:31 -- Open Access
Author(s): 
Anthony Ajua, Bertrand Lell, Benjamin Mordmüller, et al.
Reference: 
Malaria Journal 2015, 14:72 (13 February 2015)

So far, only the quantity of anti-CSP IgG has been measured and used to predict vaccination success, although quality (measured as avidity) of the antigen-antibody interaction shall be important since only a few sporozoites circulate for a short time after an infectious mosquito bite, likely requiring fast and strong binding.

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Review : Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control?

February 2, 2011 - 12:47 -- Patrick Sampao
Author(s): 
Hilary Ranson, Raphael N’Guessan, Jonathan Lines, Nicolas Moiroux, Zinga Nkuni, Vincent Corbel
Reference: 
Trends in Parasitology, Volume 27, Issue 2, February 2011, Pages 91-98

As we move into the malaria eradication era, it is vital that the implications of insecticide resistance are understood and strategies to mitigate these effects are implemented.

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