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Papua New Guinean

A High Force of Plasmodium vivax Blood-Stage Infection Drives the Rapid Acquisition of Immunity in Papua New Guinean Children

October 2, 2013 - 15:09 -- Open Access
Author(s): 
Cristian Koepfli, Kathryn L. Colborn, Benson Kiniboro, Enmoore Lin, Terence P. Speed, Peter M. Siba, Ingrid Felger, Ivo Mueller
Reference: 
PLoS Negl Trop Dis 7(9): e2403
MalariaWorld

P. vivax molFOB is considerably higher than P. falciparum molFOB (5.5 clones/child/year-at-risk).

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A High Force of Plasmodium vivax Blood-Stage Infection Drives the Rapid Acquisition of Immunity in Papua New Guinean Children

September 11, 2013 - 17:52 -- Open Access
Author(s): 
Cristian Koepfli, Kathryn L. Colborn, Benson Kiniboro, Enmoore Lin, Terence P. Speed, Peter M. Siba, Ingrid Felger, Ivo Mueller
Reference: 
PLoS Negl Trop Dis 7(9): e2403.
MalariaWorld

To identify differences in the number of blood stage infections of these species and its potential link to acquisition of immunity, we have estimated the molecular force of blood-stage infection of P. vivax (molFOB, i.e. the number of genetically distinct blood-stage infections over time), and compared it to previously reported values for P. falciparum.

Open Access | Intermittent Preventive Treatment for Malaria in Papua New Guinean Infants Exposed to Plasmodium falciparum and P. vivax: A Randomized Controlled Trial

March 30, 2012 - 12:34 -- Patrick Sampao
Author(s): 
Nicolas Senn, Patricia Rarau, Ivo Mueller, et al.
Reference: 
PLoS Med 9(3): e1001195.

MalariaWorldIn this study, 1,121 Papua New Guinean infants were enrolled into a three-arm placebo-controlled randomized trial and assigned to sulfadoxine-pyrimethamine (SP) (25 mg/kg and 1.25 mg/kg) plus amodiaquine (AQ) (10 mg/kg, 3 d, n = 374), SP plus artesunate (AS) (4 mg/kg, 3 d, n = 374), or placebo (n = 373), given at 3, 6, 9 and 12 mo. Both participants and study teams were blinded to treatment allocation.

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Rapid Diagnostic Test–Based Management of Malaria: An Effectiveness Study in Papua New Guinean Infants With Plasmodium falciparum and Plasmodium vivax Malaria

February 10, 2012 - 14:34 -- Patrick Sampao
Author(s): 
Nicolas Senn, Patricia Rarau, Doris Manong, Mary Salib, Peter Siba, Leanne J. Robinson, John Reeder, Stephen Rogerson, Ivo Mueller and Blaise Genton
Reference: 
Clinical Infectious Diseases, Volume 54, Issue 5 Pp. 644-651.

MalariaWorldWe evaluated the safety of withholding antimalarial drugs from young Papua New Guinean children with negative RDT results in areas with high levels of both Plasmodium falciparum and P. vivax infections.

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Minimal Association of Common Red Blood Cell Polymorphisms with Plasmodium falciparum Infection and Uncomplicated Malaria in Papua New Guinean School Children

October 4, 2010 - 11:57 -- Patrick Sampao
Author(s): 
Enmoore L., Livingstone T., et al.
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 828 - 833.

In a cohort of children 5–14 years of age the effect of +-thalassemia, SAO (SLC4A127), CR1 polymorphisms, and Gerbich negativity (GYPCex3) on risk of P. falciparum infections and uncomplicated illness were evaluated.

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