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Ugandan

Pharmacokinetic Predictors for Recurrent Malaria After Dihydroartemisinin-Piperaquine Treatment of Uncomplicated Malaria in Ugandan Infants

May 8, 2013 - 19:24 -- Open Access
Author(s): 
Darren J. Creek, Victor Bigira, Shelley McCormack, Emmanuel Arinaitwe, Humphrey Wanzira, Abel Kakuru, Jordan W. Tappero, Taylor G. Sandison, Niklas Lindegardh, Francois Nosten, Francesca T. Aweeka and Sunil Parikh
Reference: 
J Infect Dis. (2013) 207 (11): 1646-1654.
MalariaWorld

We conducted a prospective PK/PD study of piperaquine in 107 young children in Uganda. Samples were collected up to 28 days after 218 episodes of malaria treatment, which occurred during follow-up periods of up to 5 months. 

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Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults

April 10, 2012 - 14:59 -- Patrick Sampao
Author(s): 
Pauline Byakika-Kibwika, Mohammed Lamorde, Concepta Merry, et al.
Reference: 
J. Antimicrob. Chemother. (2012) 67 (5): 1217-1223.

MalariaWorldWe investigated the pharmacokinetics of artemether, dihydroartemisinin and lumefantrine after administration of a single dose of 80/480 mg of artemether/lumefantrine to HIV-infected adults, taken with and without lopinavir/ritonavir.

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Open Access | The association between malnutrition and the incidence of malaria among young HIV-infected and -uninfected Ugandan children: a prospective study

March 30, 2012 - 13:10 -- Patrick Sampao
Author(s): 
Arinaitwe E, Gasasira A, Verret W, Homsy J, Wanzira H, Kakuru A, Sandison TG, Young S, Tappero JW, Kamya MR, Dorsey G
Reference: 
Malaria Journal 2012, 11:90 (27 March 2012)

MalariaWorldThe incidence of malaria was compared using negative binomial regression controlling for potential confounders with measures of association expressed as an incidence rate ratio (IRR).

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Short Report: Performance of a Histidine-Rich Protein 2 Rapid Diagnostic Test, Paracheck Pf®, for Detection of Malaria Infections in Ugandan Pregnant Women

January 10, 2012 - 15:08 -- Patrick Sampao
Author(s): 
Mehul Dhorda, Patrice Piola, Georges Snounou, et al.
Reference: 
Am J Trop Med Hyg 2012 86:93-95

MalariaWorldIn this study, 81 women in Uganda in the second or third trimester of pregnancy were followed-up until delivery.

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Prescribing practices for malaria in a rural Ugandan hospital: evaluation of a new malaria treatment policy.

December 9, 2011 - 14:50 -- Patrick Sampao
Author(s): 
Ucakacon P, Achan J, Kutyabami P, Odoi A, Kalyango Nj.
Reference: 
Afr Health Sci. 2011 Aug;11 Suppl 1:S53-9.

MalariaWorldData was collected on patient demographics, prescriber factors and prescription patterns. Prescriptions were considered to conform to the new antimalarial policy if artemether-lumefantrine was prescribed for uncomplicated malaria or quinine for treatment failure or complicated malaria.

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The seroprevalence of Helicobacter pylori and its relationship to malaria in Ugandan children

December 5, 2011 - 14:00 -- Patrick Sampao
Author(s): 
Vinay Gupta, Guillermo I. Perez-Perez, Grant Dorsey, Philip J. Rosenthal, Martin J. Blaser
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 106, Issue 1, January 2012, Pages 35-42

MalariaWorldWe explored H. pylori prevalence by measuring serum IgG antibodies to H. pylori whole cell and cytotoxin-associated gene A (CagA) antigens by ELISA in a longitudinal cohort of 200 Ugandan children, aged 1–10 years at enrollment, in whom malaria incidence was followed over 572 person-years.

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Open Access | Heritability of Plasmodium Parasite Density in a Rural Ugandan Community

November 1, 2010 - 14:09 -- Patrick Sampao
Author(s): 
Rachel L. Pullan, Hasifa Bukirwa, Robert W. Snow, AND Simon Brooker
Reference: 
Am J Trop Med Hyg, Nov 2010; 83: 990 - 995.

Here, we examine the roles of host genetics and exposure in determining parasite density, and test whether effects differ with age.

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Parasitology: PCR-Based Pooling of Dried Blood Spots for Detection of Malaria Parasites: Optimization and Application to a Cohort of Ugandan Children

October 1, 2010 - 08:57 -- Patrick Sampao
Author(s): 
Michelle S. Hsiang, Michael Lin, Christian Dokomajilar, Jordan Kemere, Christopher D. Pilcher, Grant Dorsey, and Bryan Greenhouse
Reference: 
J. Clin. Microbiol., Oct 2010; 48: 3539 - 3543.

We first used laboratory-prepared samples to compare 2 DNA extraction and 4 PCR detection methods across a range of pool sizes and parasite densities. Pooled Chelex extraction of DNA, followed by nested PCR of cytochrome b, was the optimal strategy, allowing reliable detection of a single low-parasitemic sample (100 parasites/µl) in pool sizes up to 50.

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