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Western Kenya

Inhibitory Activity of Ferroquine, versus Chloroquine, against Western Kenya Plasmodium falciparum Field Isolates Determined by a SYBR Green I In Vitro Assay.

December 9, 2011 - 08:29 -- Patrick Sampao
Author(s): 
Eyase FL, Akala HM, Johnson JD, Walsh DS.
Reference: 
Am J Trop Med Hyg. 2011 Dec;85(6):984-8.

MalariaWorldThese findings support the notion that FQ could be useful in treating persons with P. falciparum malaria.

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Open Access | Surveillance of vector populations and malaria transmission during the 2009/10 El Nino event in the western Kenya highlands: opportunities for early detection of malaria hyper-transmission

July 25, 2011 - 15:15 -- Patrick Sampao
Author(s): 
Ednah N Ototo, Andrew K Githeko, Christine L Wanjala and Thomas W Scott
Reference: 
Parasites & Vectors 2011, 4:144

Indoor resting female adult malaria vectors were collected in western Kenya highlands in four selected villages categorized into two valley systems, the U-shaped (Iguhu and Emutete) and the V-shaped valleys (Marani and Fort Ternan) for eight months.

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Antimalarial Drug Sensitivity Profile of Western Kenya Plasmodium falciparum Field Isolates Determined by a SYBR Green I in vitro Assay and Molecular Analysis

July 8, 2011 - 09:02 -- Patrick Sampao
Author(s): 
Hoseah M. Akala., Fredrick L. Eyase., Douglas S. Walsh., et al
Reference: 
Am J Trop Med Hyg 2011 vol. 85 no. 1 34-41

In 2007–2008, we assayed 121 P. falciparum field isolates from western Kenya for 50% inhibitory concentrations (IC50) against 6 antimalarial drugs using a SYBR Green I in vitro assay: 91 immediate ex vivo (IEV) and 30 culture-adapted, along with P. falciparum reference clones D6 (chloroquine [CQ] sensitive) and W2 (CQ resistant).

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Open Access | Predation efficiency of Anopheles gambiae larvae by aquatic predators in western Kenya highlands

July 7, 2011 - 12:06 -- Patrick Sampao
Author(s): 
Eliningaya J Kweka, Guofa Zhou, Thomas M Gilbreath III, Yaw Afrane, Mramba Nyindo, Andrew K Githeko and Guiyun Yan
Reference: 
Parasites & Vectors 2011, 4:12, 5 July 2011

These experiments provide insight into the efficiency of specific natural predators against mosquito larvae. These naturally occurring predators may be useful in biocontrol strategies for aquatic stage An. gambiae mosquitoes.

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Open Access | Evaluation of two methods of estimating larval habitat productivity in western Kenya highlands

June 30, 2011 - 13:33 -- Patrick Sampao
Author(s): 
Eliningaya J Kweka, Guofa Zhou, Ming-Chieh Lee, Thomas M Gilbreath III, Franklin Mosha, Stephen Munga, Andrew K Githeko and Guiyun Yan
Reference: 
Parasites & Vectors 2011, 4:110, 17 June 2011

These findings suggest that the aerial sampler is the better of the two methods for estimating the productivity of An. gambiae s.l. and An. funestus in the western Kenya highlands and possibly other malaria endemic parts of Africa.

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Open Access | Insecticide-treated net (ITN) ownership, usage, and malaria transmission in the highlands of western Kenya

June 20, 2011 - 14:16 -- Patrick Sampao
Author(s): 
Harrysone E Atieli, Guofa Zhou, Yaw A Afrane, Ming-Chieh Lee, Isaac Mwanzo, Andrew K Githeko and Guiyun Yan
Reference: 
Parasites & Vectors 2011, 4:11 , 18 June 2011

This study examined ITN ownership and underlying factors for among-household variation in use, and malaria transmission in two highland regions of western Kenya.

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Open Access | Identification of malaria transmission and epidemic hotspots in the Western Kenya highlands: its application to malaria epidemic prediction.

May 28, 2011 - 10:12 -- Patrick Sampao
Author(s): 
Christine L Wanjala, John Waitumbi, Guofa Zhou and Andrew K Githeko
Reference: 
Parasites & Vectors 2011, 4:81

This study showed that the V-shaped ecosystems have very low malaria prevalence and few individuals with an immune response to two major malaria antigens and they can be considered as epidemic hotspots.

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Open Access | A cohort study of Plasmodium falciparum infection dynamics in Western Kenya Highlands

September 27, 2010 - 14:32 -- Patrick Sampao
Author(s): 
Baliraine FN, Afrane YA, Amenya DA, Bonizzoni M, Vardo-Zalik AM, Menge DM, Githeko AK, Yan G
Reference: 
BMC Infectious Diseases 2010, 10:283 (24 September 2010)

These data demonstrate that despite the relatively recent spread of malaria to the highlands, parasite populations seem to have stabilized with no evidence of bottlenecks between seasons, while the ability of residents to clear or control infections indicates presence of effective anti-plasmodial immune mechanisms.

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Open Access | Mosquito nets in a rural area of Western Kenya: ownership, use and quality

September 7, 2010 - 08:52 -- Patrick Sampao
Author(s): 
Githinji S, Herbst S, Kistemann T, Noor AM
Reference: 
Malaria Journal 2010, 9:250 (2 September 2010)

This study analyses the use and quality of nets owned by households in an area of high net coverage.

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Evaluation of Recurrent Parasitemia after Artemether-Lumefantrine Treatment for Uncomplicated Malaria in Children in Western Kenya

September 2, 2010 - 13:16 -- Patrick Sampao
Author(s): 
Joseph V. Woodring, Bernhards Ogutu, David Schnabel, John N. Waitumbi, Cara H. Olsen, Douglas S. Walsh, D. Gray Heppner, Jr.,and Mark E. Polhemus
Reference: 
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 458-464

Although recrudescence in some cannot be ruled out, our cohort had a shorter median time to RP compared with other artemether-lumefantrine treatment studies.

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