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Open Access | Tracing the origins and signatures of selection of antifolate resistance in island populations of Plasmodium falciparum

June 11, 2010 - 08:35 -- Patrick Sampao
Salgueiro P, Vicente JL, Ferreira C, Teofilo V, Galvao A, do Rosario VE, Cravo P, Pinto J
BMC Infectious Diseases 2010, 10:163 (9 June 2010)

This study provides additional evidence for the crucial role of gene flow and drug selective pressures in the rapid spread of SP resistance in P. falciparum populations, from only a few mutation events giving rise to resistance-associated mutants.

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