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Brazil

Open Access | Population dynamics, structure and behaviour of Anopheles darlingi in a rural settlement in the Amazon rainforest of Acre, Brazil

June 28, 2011 - 14:12 -- Kabogo Ndegwa
Author(s): 
Moutinho PR, Gil LH, Cruz RB, Ribolla PE
Reference: 
Malaria Journal 2011, 10:174 (24 June 2011)

Anopheles darlingi depends on forested regions for their larval and adult survival.

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Open Access | Evaluation of allelic forms of the erythrocyte binding antigen 175 (EBA-175) in Plasmodium falciparum field isolates from Brazilian endemic area

May 31, 2011 - 10:07 -- Kabogo Ndegwa
Author(s): 
Perce-da-Silva DS, Banic DM, Lima-Junior JC, Santos F, Daniel-Ribeiro CT, de Oliveira-Ferreira J, Pratt-Riccio LR
Reference: 
Malaria Journal 2011, 10:146 (26 May 2011)

These findings confirm the dimorphism of EBA175, since only the two types of fragments were amplified, C-fragment and F-fragment.

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Open Access | Unexpectedly long incubation period of Plasmodium vivax malaria, in the absence of chemoprophylaxis, in patients diagnosed outside the transmission area in Brazil

May 18, 2011 - 10:08 -- Kabogo Ndegwa
Author(s): 
Patricia Brasil, Anielle de Pina Costa, Renata Saraiva Pedro, Clarisse da Silveira Bressan, Sidney da Silva, Pedro Luiz Tauil, Claudio Tadeu Daniel-Ribeiro
Reference: 
Malaria Journal 2011, 10:122 (14 May 2011)

The authors emphasize that considering malaria as a possible cause of febrile syndrome should be a post-travel routine, independent of the time elapsed after exposure in the transmission area, even in the absence of malaria chemoprophylaxis.

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Evaluation of the naturally acquired antibody immune response to the Pv200L N-terminal fragment of Plasmodium vivax merozoite surface protein-1 in four areas of the Amazon Region of Brazil.

February 17, 2011 - 13:06 -- Patrick Sampao
Author(s): 
Storti-Melo LM., Souza-Neiras WC., Machado RL ., et al
Reference: 
Am J Trop Med Hyg. 2011 Feb;84(2 Suppl):58-63.

Results of this study provide evidence that Pv200L is a naturally immunogenic fragment of the PvMSP-1 and is associated with the degree of exposure to parasites.

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Open Access | Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy

December 14, 2010 - 06:25 -- Kabogo Ndegwa
Author(s): 
Gama BE, Almeida-de-Oliveira NK, de Souza JM, Santos F, de Carvalho LJ, Melo YF, Rosenthal PJ, Daniel-Ribeiro CT, Ferreira-da-Cruz M
Reference: 
Malaria Journal 2010, 9:355 (8 December 2010)

Although some polymorphism in pfmdr1 and pfatpase6 were verified, no reported haplotypes in both genes that may mediate altered response to ACT was detected before the introduction of this therapy in Brazil.

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Open Access | Genetic variability and natural selection at the ligand domain of the Duffy binding protein in Brazilian Plasmodium vivax populations

November 26, 2010 - 09:40 -- Kabogo Ndegwa
Author(s): 
Tais N Sousa, Eduardo M Tarazona-Santos, Daniel J Wilson, Ana P Madureira, Paula RK Falcao, Cor JF Fontes, Luiz HS Gil, Marcelo U Ferreira, Luzia H Carvalho, Cristiana FA Brito
Reference: 
Malaria Journal 2010, 9:334 (22 November 2010)

This study shows that some polymorphisms of PvDBPII are present near the erythrocyte-binding domain and might serve to elude antibodies that inhibit cell invasion. Therefore, these polymorphisms should be taken into account when designing vaccines aimed at eliciting antibodies to inhibit erythrocyte invasion.

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Open Access | Evidence-based public health and prospects for malaria control in Brazil

November 9, 2010 - 08:25 -- Kabogo Ndegwa
Author(s): 
Marcelo Urbano Ferreira, Monica da Silva-Nunes
Reference: 
The Journal of Infection in Developing Countries, Vol 4, No 09

Despite intensive control efforts over the past decades, Brazil still accounts for more than 50% of the malaria burden in the Americas and the Caribbean, with 458,041 slide-confirmed cases reported countrywide in 2007.

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Open Access | Cost effectiveness of OptiMal(R) rapid diagnostic test for malaria in remote areas of the Amazon Region, Brazil

October 16, 2010 - 07:50 -- Kabogo Ndegwa
Author(s): 
Fernandes de Oliveira M, de Castro Gomes A, Toscano CM
Reference: 
Malaria Journal 2010, 9:277 (11 October 2010)

Microscopy is more cost-effective than OptiMal(R) in these remote areas if high accuracy of microscopy is maintained in the field. Decision regarding use of rapid tests for diagnosis of malaria in these areas depends on current microscopy accuracy in the field.

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Increasing incidence of malaria in the Negro River basin, Brazilian Amazon

July 13, 2010 - 06:50 -- Patrick Sampao
Author(s): 
A.C. Cabral, N.F. Fé, M.C. Suárez-Mutis, M.N. Bóia, F.A. Carvalho-Costa
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 8, August 2010, Pages 556-562

This study suggests that urban and periurban areas of this municipality are highly susceptible to epidemic malaria, which is endemic in the Yanomami Indian reservation near the city.

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Open Access | Concurrent Helminthic Infection Protects Schoolchildren with Plasmodium vivax from Anemia

June 25, 2010 - 09:07 -- Kabogo Ndegwa
Author(s): 
Gisely Cardoso Melo, Roberto Carlos Reyes-Lecca, Sheila Vitor-Silva, Wuelton Marcelo Monteiro, Marilaine Martins, Silvana Gomes Benzecry, Maria das Graças Costa Alecrim, Marcus Vinícius Guimarães Lacerda
Reference: 
PLoS ONE 5(6): e11206

For the first time, a cohort study showed that intestinal helminthes protect against hemoglobin decrease during an acute malarial attack by P. vivax.

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