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Brazil

Efficacy and safety of artemisinin-based combination therapy and chloroquine with concomitant primaquine to treat Plasmodium vivax malaria in Brazil: an open label randomized clinical trial

January 24, 2018 - 13:30 -- Open Access
Author(s): 
André Daher, Dhelio Pereira, David G. Lalloo, et al.
Reference: 
Malaria Journal 2018 17:45, 24 January 2018

This study demonstrated the efficacy and safety of all three regimens that were tested with 42-day cure rates that meet World Health Organization criteria.

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Mitochondrial genome of Plasmodium vivax/simium detected in an endemic region for malaria in the Atlantic Forest of Espírito Santo state, Brazil: do mosquitoes, simians and humans harbour the same parasite?

October 31, 2017 - 15:03 -- Open Access
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Author(s): 
Julyana Cerqueira Buery, Priscila Thihara Rodrigues, Crispim Cerutti Jr., et al.
Reference: 
Malaria Journal 2017 16:437, 30 October 2017

These findings strengthen support for the hypothesis that in the Atlantic Forest, and especially in the state with the highest frequency of bromeliad-malaria in Brazil, parasites with similar molecular backgrounds are shared by humans and simians.

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Socioeconomic and demographic characterization of an endemic malaria region in Brazil by multiple correspondence analysis

October 4, 2017 - 16:09 -- Open Access
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Author(s): 
Raquel M. Lana, Thais I. S. Riback, Cláudia T. Codeço, et al.
Reference: 
Malaria Journal 2017 16:397, 2 October 2017

Living conditions in the study area are strongly geographically structured.

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G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon

June 15, 2017 - 15:43 -- Open Access
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Author(s): 
Jamille G. Dombrowski, Rodrigo M. Souza, Claudio R. F. Marinho, et al.
Reference: 
Malaria Journal 2017 16:253, 15 June 2017

The data indicates that ~1/23 males from the Alto do Juruá could be G6PD deficient and at risk of haemolytic anaemia if treated with primaquine.

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The role of spatial mobility in malaria transmission in the Brazilian Amazon: The case of Porto Velho municipality, Rondônia, Brazil (2010-2012)

March 28, 2017 - 15:19 -- Open Access
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Author(s): 
Jussara Rafael Angelo, Tony Hiroshi Katsuragawa, Paulo Chagastelles Sabroza, Lino Augusto Sander de Carvalho, Luiz Hildebrando Pereira da Silva, Carlos Afonso Nobre
Reference: 
PLoS ONE 12(2): e0172330

The Porto Velho municipality exhibits high malaria endemicity and plays an important role in disseminating the parasite to other municipalities in the Amazon and even to non-endemic areas of the country.

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A systematic review on malaria sero-epidemiology studies in the Brazilian Amazon: insights into immunological markers for exposure and protection

March 14, 2017 - 13:02 -- Open Access
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Author(s): 
Pedro M. Folegatti, André M. Siqueira, Wuelton M. Monteiro, Marcus Vinícius G. Lacerda, Chris J. Drakeley and Érika M. Braga
Reference: 
Malaria Journal 2017 16:107, 7 March 2017

This systematic review identifies potential biomarkers of P. falciparum and P. vivax exposure in areas with variable and unstable malaria transmission in Brazil.

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Rapid diagnostic test for G6PD deficiency in Plasmodium vivax-infected men: a budget impact analysis based in Brazilian Amazon

January 7, 2017 - 15:11 -- Open Access
Author(s): 
Henry Maia Peixoto, Marcelo Augusto Mota Brito, Maria Regina Fernandes de Oliveira, et al.
Reference: 
Tropical Medicine & International Health, Volume 22, Issue 1, January 2017, Pages 21–31

A strategy based on the use of CS-G6PD would result in better use of public resources in the Brazilian Amazon.

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Challenges for malaria elimination in Brazil

May 24, 2016 - 15:44 -- Open Access
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Author(s): 
Marcelo U. Ferreira and Marcia C. Castro
Reference: 
Malaria Journal 2016 15:284, 20 May 2016

Brazil currently contributes 42 % of all malaria cases reported in the Latin America and the Caribbean, a region where major progress towards malaria elimination has been achieved in recent years.

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Polymorphisms in Plasmodium vivax Circumsporozoite Protein (CSP) Influence Parasite Burden and Cytokine Balance in a Pre-Amazon Endemic Area from Brazil

March 19, 2016 - 18:43 -- Open Access
Author(s): 
Bruno de Paulo Ribeiro, Gustavo Capatti Cassiano, Flávia Raquel Fernandes Nascimento, et al.
Reference: 
PLoS Negl Trop Dis 10(3): e0004479

Mechanisms involved in severe P. vivax malaria remain unclear.

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Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas

February 23, 2016 - 16:48 -- Open Access
Author(s): 
Larissa Rodrigues Gomes, Natália Ketrin Almeida-de-Oliveira, Maria de Fatima Ferreira-da-Cruz, et al.
Reference: 
Malaria Journal 2016 15:96, 18 February 2016

Considering that primaquine (PQ) efficacy is highly dependent on concurrent administration of a blood schizontocidal agent and that PQ could not circumvent CQR, together with the fact that no pvmdr1 mutation should be expected in successfully cured patients, these findings seem to indicate that the pvmdr1 gene is not a reliable marker of CQR.

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