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Malaysia

Prevalence of malaria and its risk factors in Sabah Malaysia

December 2, 2019 - 15:00 -- Open Access
Author(s): 
Abdul Rahman R, Aniza I, Zetty Sofia MZ
Reference: 
International Journal of Infectious Diseases 2019 Nov 27. pii: S1201-9712(19)30466-7.

This study aims to determine the prevalence of malaria in Sabah and its potential risk factors.

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Diversity pattern of Plasmodium knowlesi merozoite surface protein 4 (MSP4) in natural population of Malaysia

November 30, 2019 - 04:44 -- Open Access
Author(s): 
Ahmed MA, Saif A, Quan FS
Reference: 
PLoS One. 2019 Nov 21;14(11):e0224743.

Human infections due to the monkey malaria parasite Plasmodium knowlesi are increasingly being reported from Malaysia. The parasite causes high parasitaemia, severe and fatal malaria in humans thus there is a need for urgent measures for its control.

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Evidence of asymptomatic submicroscopic malaria in low transmission areas in Belaga district, Kapit division, Sarawak, Malaysia

May 7, 2019 - 13:33 -- Open Access
Tags: 
Author(s): 
Adela Ida Jiram, Choo Huck Ooi, José Miguel Rubio, Shamilah Hisam, Govindarajoo Karnan, Nurnadiah Mohd Sukor, Mohd Mafie Artic, Nor Parina Ismail and Nor Wahida Alias
Reference: 
Malaria Journal 2019 18:156, 2 May 2019

Malaysia has declared its aim to eliminate malaria with a goal of achieving zero local transmission by the year 2020. However, targeting the human reservoir of infection, including those with asymptomatic infection is required to achieve malaria elimination. Diagnosing asymptomatic malaria is not as straightforward due to the obvious lack of clinical manifestations and often subpatent level of parasites. Accurate diagnosis of malaria is important for providing realistic estimates of malaria burden and preventing misinformed interventions. Low levels of parasitaemia acts as silent reservoir of transmission thus remains infectious to susceptible mosquito vectors. Hence, the aim of this study is to investigate the prevalence of asymptomatic submicroscopic malaria (SMM) in the District of Belaga, Sarawak.

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Plasmodium knowlesi clinical isolates from Malaysia show extensive diversity and strong differential selection pressure at the merozoite surface protein 7D (MSP7D)

May 3, 2019 - 17:21 -- Open Access
Author(s): 
Md. Atique Ahmed and Fu-Shi Quan
Reference: 
Malaria Journal 2019 18:150, 29 April 2019

Background

The high proportion of human cases due to the simian malaria parasite Plasmodium knowlesi in Malaysia is a cause of concern, as they can be severe and even fatal. Merozoite surface protein 7 (MSP7) is a multigene family which forms a non-covalent complex with MSP-1 prior to receptor-ligand recognition in Plasmodium falciparum and thus an important antigen for vaccine development. However, no study has been done in any of the ortholog family members in P. knowlesi from clinical samples. This study investigates the level of polymorphism, haplotypes, and natural selection acting at the pkmsp-7D gene in clinical samples from Malaysia.

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Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance

December 12, 2018 - 16:07 -- Open Access
Author(s): 
Matthew J. Grigg, Timothy William, Nicholas M. Anstey, et al.
Reference: 
Malaria Journal 2018 17:463, 10 December 2018

There is no suspected or confirmed evidence of endemic artemisinin-resistant P. falciparum in this pre-elimination setting in Sabah, Malaysia.

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Diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium knowlesi in Malaysia

July 31, 2018 - 15:29 -- Open Access
Author(s): 
Md Atique Ahmed, Yee Ling Lau and Fu-Shi Quan
Reference: 
Malaria Journal 2018 17:274, 27 July 2018

This study is the first to report on the genetic diversity and natural selection of full-length pktrap.

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Genetic diversity and natural selection of Plasmodium knowlesi merozoite surface protein 1 paralog gene in Malaysia

March 15, 2018 - 07:00 -- Open Access
Author(s): 
Md Atique Ahmed, Muh Fauzi and Eun-Taek Han
Reference: 
Malaria Journal 2018 17:115, 14 March 2018

This study is the first to report on the genetic diversity and natural selection of pkmsp1p.

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Phylogenetic analysis of simian Plasmodium spp. infecting Anopheles balabacensis Baisas in Sabah, Malaysia

October 12, 2017 - 15:24 -- Open Access
Author(s): 
Tock H. Chua, Benny O. Manin, Sylvia Daim, Indra Vythilingam, Chris Drakeley
Reference: 
PLoS Negl Trop Dis 11(10): e0005991

Background

Anopheles balabacensis of the Leucospyrus group has been confirmed as the primary knowlesi malaria vector in Sabah, Malaysian Borneo for some time now. Presently, knowlesi malaria is the only zoonotic simian malaria in Malaysia with a high prevalence recorded in the states of Sabah and Sarawak.

Methodology/Principal findings

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Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations

October 3, 2017 - 17:18 -- Open Access
Author(s): 
Ernest Diez Benavente, Paola Florez de Sessions, Taane G. Clark, et al.
Reference: 
PLoS Genet 13(9): e1007008

The macaque parasite Plasmodium knowlesi is a significant concern in Malaysia where cases of human infection are increasing.

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NOT Open Access | Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi

September 23, 2017 - 06:21 -- NOT Open Access
Author(s): 
Varakorn Kosaisavee, Rossarin Suwanarusk, Bruce Russell, et al.
Reference: 
Blood Volume: 130, Issue: 11, Pages: 1357-1363

Two malaria parasites of Southeast Asian macaques, Plasmodium knowlesi and P cynomolgi, can infect humans experimentally.

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