Brazil

NOT Open Access | Monitoring the Efficacy of Chloroquine-Primaquine Therapy for Uncomplicated Plasmodium vivax Malaria in the Main Transmission Hot Spot of Brazil

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Author(s):

Simone Ladeia-Andrade, Maria José Menezes, Taís Nóbrega de Sousa, Ana Carolina R. Silvino, Jaques F. de Carvalho Jr., Laís C. Salla, Odaílton A. Nery, Gladson N. P. de Melo, Rodrigo M. Corder, Priscila T. Rodrigues and Marcelo U. Ferreira

Reference:

Antimicrob. Agents Chemother. April 2019 63:e01965-18

Emerging Plasmodium vivax resistance to chloroquine (CQ) may undermine malaria elimination efforts in South America. CQ-resistant P. vivax has been found in the major port city of Manaus but not in the main malaria hot spots across the Amazon Basin of Brazil, where CQ is routinely coadministered with primaquine (PQ) for radical cure of vivax malaria. Here we randomly assigned 204 uncomplicated vivax malaria patients from Juruá Valley, northwestern Brazil, to receive either sequential (arm 1) or concomitant (arm 2) CQ-PQ treatment.

Continent:

South America

Country:

Brazil

Medical Treatment:

chloroquine (CQ)

Vector competence, vectorial capacity of Nyssorhynchus darlingi and the basic reproduction number of Plasmodium vivax in agricultural settlements in the Amazonian Region of Brazil

Tags:

malaria

Author(s):

Maria Anice M. Sallum, Jan E. Conn, Eduardo Massad, et al.

Reference:

Malaria Journal 2019 18:117, 4 April 2019

In spite of low vector competence of Ny. darlingi to P. vivax, parasite propagation in the human population is enhanced by the high human-biting rate, and relatively high vectorial capacity.

Country:

Brazil

Effects of anthropogenic landscape changes on the abundance and acrodendrophily of Anopheles (Kerteszia) cruzii, the main vector of malaria parasites in the Atlantic Forest in Brazil

Tags:

malaria parasites

Author(s):

Antônio Ralph Medeiros-Sousa, Rafael de Oliveira Christe, Ana Maria Ribeiro de Castro Duarte, Luis Filipe Mucci, Walter Ceretti-Junior and Mauro Toledo Marrelli

Reference:

Malaria Journal 2019 18:110, 2 April 2019

While the data indicate that changes in landscape due to human activities lead to a reduction in An. cruzii abundance, such changes may increase the contact rate between this species and humans living on the edges of forest fragments where An. cruzii is found.

Country:

Brazil

Use and retention of long-lasting insecticidal nets (LLINs) in a malaria risk area in the Brazilian Amazon: a 5-year follow-up intervention

Tags:

malaria

Author(s):

Jessica Oliveira de Sousa, Bernardino Claudio de Albuquerque, José Rodrigues Coura and Martha Cecilia Suárez-Mutis

Reference:

Malaria Journal 2019 18:100, 25 March 2019

High ownership and retention of the LLINs was observed in the intervention group.

Organization:

World Health Organisation (WHO)

Country:

Brazil

Medical Treatment:

long-lasting insecticidal nets (LLINs)

Field evaluation of malaria malachite green loop-mediated isothermal amplification in health posts in Roraima state, Brazil

Tags:

malaria

Author(s):

Heather M. Kudyba, Jaime Louzada, Dragan Ljolje, Karl A. Kudyba, Vasant Muralidharan, Joseli Oliveira-Ferreira and Naomi W. Lucchi

Reference:

Malaria Journal 2019 18:98, 25 March 2019

MG-LAMP is a sensitive and specific assay that may be useful for the detection of malaria parasites in remote healthcare settings.

Country:

Brazil

Diversity of Anopheles mosquitoes from four landscapes in the highest endemic region of malaria transmission in Brazil

Tags:

malaria

Author(s):

L.M.O. Martins, M.R. David, R. Maciel‐de‐Freitas, T.F. Silva‐do‐Nascimento

Reference:

Journal of Vector Ecology, Volume 43, Issue 2 December 2018 Pages 235-244

Malaria transmission in South America is overwhelmingly located in the Amazon region with limited cases outside that biome.

Country:

Brazil

Not Open Access | A new pathogen spillover from domestic to wild animals: Plasmodium juxtanucleare infects free-living passerines in Brazil

Tags:

plasmodium juxtanucleare

Author(s):

Francisco C. Ferreira-Junior, Daniela de Angeli Dutra, Érika M. Braga, et al.

Reference:

Parasitology, Volume 145 / Issue 14, December 2018, pp 1949 – 1958

Habitat modification may facilitate the emergence of novel pathogens, and the expansion of agricultural frontiers make domestic animals important sources of pathogen spillover to wild animals.

Country:

Brazil

Strategy to improve malaria surveillance system preventing transfusion-transmitted malaria in blood banks using molecular diagnostic

Tags:

malaria

Author(s):

Sérgio Antônio Batista-dos-Santos, Daniel Roberto C. Freitas, Milene Raiol, Gleyce F. Cabral, Ana Cecília Feio, Marinete M. Póvoa, Maristela G. Cunha and Ândrea Ribeiro-dos-Santos

Reference:

Malaria Journal 2018 17:344, 1 October 2018

Molecular diagnostic using mt-qPCR was effective in revealing infected potential donors with good perspectives to be applied as screening routine of asymptomatic carriers for preventing transfusion-transmitted malaria in blood banks.

Country:

Brazil

Efficacy and safety of artemisinin-based combination therapy and chloroquine with concomitant primaquine to treat Plasmodium vivax malaria in Brazil: an open label randomized clinical trial

Tags:

plasmodium viva, malaria

Author(s):

André Daher, Dhelio Pereira, David G. Lalloo, et al.

Reference:

Malaria Journal 2018 17:45, 24 January 2018

This study demonstrated the efficacy and safety of all three regimens that were tested with 42-day cure rates that meet World Health Organization criteria.

Organization:

The World Health Organization

Country:

Brazil

Medical Treatment:

artemisinin-based combinations

Mitochondrial genome of Plasmodium vivax/simium detected in an endemic region for malaria in the Atlantic Forest of Espírito Santo state, Brazil: do mosquitoes, simians and humans harbour the same parasite?

Tags:

malaria

Author(s):

Julyana Cerqueira Buery, Priscila Thihara Rodrigues, Crispim Cerutti Jr., et al.

Reference:

Malaria Journal 2017 16:437, 30 October 2017

These findings strengthen support for the hypothesis that in the Atlantic Forest, and especially in the state with the highest frequency of bromeliad-malaria in Brazil, parasites with similar molecular backgrounds are shared by humans and simians.

Country:

Brazil

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