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Africa

Inhibiting the Mammalian Target of Rapamycin Blocks the Development of Experimental Cerebral Malaria

July 4, 2015 - 07:50 -- Open Access
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Author(s): 
Emile B. Gordon, Geoffrey T. Hart, Susan K. Pierce, et al.
Reference: 
mBio.00725-15, 2 June 2015 mBio vol. 6 no. 3 e00725-15

Malaria is an infectious disease caused by parasites of several Plasmodium spp.

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Malaria continues to select for sickle cell trait in Central Africa

June 4, 2015 - 08:27 -- Open Access
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Author(s): 
Eric Elguero, Lucrèce M. Délicat-Loembet, Franck Prugnolle, et al.
Reference: 
PNAS June 2, 2015 vol. 112 no. 22 7051-7054

Sickle cell disease (SCD) is a genetic disorder that poses a serious health threat in tropical Africa, which the World Health Organization has declared a public health priority.

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NOT Open Access | Ethnic differences in susceptibility to malaria: What have we learned from immuno-epidemiological studies in West Africa?

April 16, 2015 - 11:23 -- NOT Open Access
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Author(s): 
Charles Arama, Bakary Maiga, Amagana Dolo, Bourema Kouriba, Boubacar Traore, Peter D. Crompton, Susan K. Pierce, Marita Troye-Blomberg, Louis H. Miller, Ogobara K. Doumbo
Reference: 
Acta Tropica, Volume 146, June 2015, Pages 152–156

In this mini-review we discuss and summarize what we have learned about African ethnic differences in susceptibility to malaria from immuno-epidemiological studies.

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Polymorphisms in Plasmodium falciparum K13-Propeller in Angola and Mozambique after the Introduction of the ACTs

March 30, 2015 - 17:26 -- Open Access
Author(s): 
Carlos Escobar, Sara Pateira, Elsa Lobo, Lis Lobo, Rosa Teodosio, Fernanda Dias, Natercia Fernandes, Ana Paula Arez, Luis Varandas, Fatima Nogueira
Reference: 
PLoS ONE 10(3): e0119215

We report the presence of SNPs in Plasmodium falciparum K13-propeller gene in two African countries, Angola and Mozambique, where malaria is a serious public health problem.

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Comparison of azithromycin plus chloroquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in children in Africa: a randomized, open-label study

March 16, 2015 - 14:08 -- Open Access
Author(s): 
Richa Chandra, Patrick Ansah, Issaka Sagara, Ali Sie, Alfred B Tiono, Abdoulaye A Djimde, Qinying Zhao, Jeffery Robbins, Louis K Penali, Bernhards Ogutu
Reference: 
Malaria Journal 2015, 14:108 (10 March 2015)

In this study, non-inferiority of AZCQ to AL was not demonstrated.

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Measuring the wrong parameter for evaluating impact of malaria control

March 14, 2015 - 14:51 -- William Jobin
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In the latest Annual Report of PMI (April 2014), they cite the reduction in mortality rates of children under five as proof of the beneficial impact of the anti-malarial work of PMI. Figure 1 of the report cites the following figures for the 15 PMI focus countries which have the best data. However, as in the past, they have not done a comparison with other countries in Africa. The same is true in general of the reports from the Roll Back Malaria program. For some strange reason they don't want to measure changes in malaria prevalence.

Lessons from the failure of the WHO Garki Project

March 11, 2015 - 12:50 -- William Jobin

Do any of you have experience with the Garki Project, to add to my comments below? I would especially appreciate comments from those of you who knew what the thinking inside WHO Geneva was, at the time.

What lessons can we learn from the failure of the WHO Garki Malaria Project in Kano, Nigeria, 1970-1980?

NOT Open Access | Seasonal variation in wing size and shape between geographic populations of the malaria vector, Anopheles coluzzii in Burkina Faso (West Africa)

February 18, 2015 - 13:02 -- NOT Open Access
Author(s): 
Kevin Hidalgo, Jean-Pierre Dujardin, Karine Mouline, Roch K. Dabiré, David Renault, Frederic Simard
Reference: 
Acta Tropica Volume 143, March 2015, Pages 79–88

The mosquito, Anopheles coluzzii is a major vector of human malaria in Africa with widespread distribution throughout the continent.

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