When coverage of effective treatment is taken into account, higher country level estimates of average EIR and thus higher disease burden, are obtained for a given prevalence level, especially where access to treatment is high, and prevalence relatively low.
The in utero environment profoundly impacts childhood neurodevelopment and behaviour.
The direct negative effects of invasive plant species on agriculture and biodiversity are well known, but their indirect effects on human health, and particularly their interactions with disease-transmitting vectors, remains poorly explored.
What are the benefits of eradicating malaria, compared to suppressing it?
Eradication is a distant goal, perhaps one not attainable in our lifetime – perhaps never. Even its definition is somewhat vague, as there are so many forms of malaria. However suppression of malaria transmission is real and immediately attainable, something we are actually doing right now, in various degrees.
This month’s report by WHO/UNICEF on ‘Achieving the Malaria MDG Target’ indicated that over 50% of Congolese children sleep under bednets. However these overly optimistic assertions are contradicted by a careful malaria survey conducted in 2007 in 8,000 households in the Congo, which indicated a blood-slide positivity of 33.5% and only 7% of children sleeping under bednets (Molecular malaria epidemiology…… by Taylor et al DOI: 10.1371/journal.pone.0016420.
The triterpenes balsaminoside B (1) and karavilagenin C (2) were isolated from the African medicinal plant Momordica balsamina L. Karavoates B (3) and D (4) were synthesized by diacylation of 2 with acetic and propionic anhydrides, respectively.
I invite you to help me imagine a solid and realistic approach to malaria control in Africa, rather than continuing our criticism of the current poorly focussed and unsustainable attempts by WHO, RBM and the US PMI. I think we need a permanent Institute where African malaria people can develop, implement and expand anti-malarial measures. Because the current emphasis on drugs, biocides and bednets is inherently unsustainable, let us take a more sensible and rational approach which utilizes ecological changes.
Plasmodium falciparum eba-175 genetic diversity appeared to increase following the exodus of Asian ancestors from Africa.
An analysis of information released by the World Health Organization reveals that the concepts of blue marble health extend beyond neglected tropical diseases to also include “the big three diseases”: HIV/AIDS, tuberculosis, and malaria.
This meeting report presents the outcomes of a workshop held in Bangkok on December 1st 2014, where the following challenges were discussed: the threat of resistance to artemisinin and artemisinin-based combination therapy in the Greater Mekong Sub-region (GMS) and in Africa; access to treatment for most at risk and hard to reach population; insecticide resistance, residual and outdoors transmission.