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Africa

Distribution of malaria exposure in endemic countries in Africa considering country levels of effective treatment

October 5, 2015 - 16:43 -- Open Access
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Author(s): 
Melissa Penny, Nicolas Maire, Caitlin Bever, Peter Pemberton-Ross, Olivier Briët, David Smith, Peter Gething, Thomas Smith
Reference: 
Malaria Journal 2015, 14:384 (5 October 2015)

When coverage of effective treatment is taken into account, higher country level estimates of average EIR and thus higher disease burden, are obtained for a given prevalence level, especially where access to treatment is high, and prevalence relatively low.

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Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway

September 30, 2015 - 17:20 -- Open Access
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Author(s): 
Chloë R. McDonald, Lindsay S. Cahill, Kevin C. Kain, et al.
Reference: 
PLoS Pathog 11(9): e1005140

The in utero environment profoundly impacts childhood neurodevelopment and behaviour.

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The Invasive American Weed Parthenium hysterophorus Can Negatively Impact Malaria Control in Africa

September 21, 2015 - 17:09 -- Open Access
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Author(s): 
Vincent O. Nyasembe, Xavier Cheseto, Fatma Kaplan, Woodbridge A. Foster, Peter E. A. Teal, James H. Tumlinson, Christian Borgemeister, Baldwyn Torto
Reference: 
PLoS ONE 10(9): e0137836

The direct negative effects of invasive plant species on agriculture and biodiversity are well known, but their indirect effects on human health, and particularly their interactions with disease-transmitting vectors, remains poorly explored.

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Eradication or suppresion?

September 21, 2015 - 11:36 -- William Jobin

What are the benefits of eradicating malaria, compared to suppressing it?

Eradication is a distant goal, perhaps one not attainable in our lifetime – perhaps never. Even its definition is somewhat vague, as there are so many forms of malaria. However suppression of malaria transmission is real and immediately attainable, something we are actually doing right now, in various degrees.

Why can't WHO give out accurate data about bednets ?

September 19, 2015 - 20:14 -- William Jobin
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This month’s report by WHO/UNICEF on ‘Achieving the Malaria MDG Target’ indicated that over 50% of Congolese children sleep under bednets. However these overly optimistic assertions are contradicted by a careful malaria survey conducted in 2007 in 8,000 households in the Congo, which indicated a blood-slide positivity of 33.5% and only 7% of children sleeping under bednets (Molecular malaria epidemiology…… by Taylor et al DOI: 10.1371/journal.pone.0016420.

NOT Open Access | In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents

September 16, 2015 - 13:06 -- NOT Open Access
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Author(s): 
Luiz Francisco Rocha e Silva, Cátia Ramalhete, Karla Lagos Nogueira, Silva Mulhovo, Maria-José U. Ferreira, Adrian Martin Pohlit
Reference: 
European Journal of Medicinal Chemistry, Volume 102, 18 September 2015, Pages 398–402

The triterpenes balsaminoside B (1) and karavilagenin C (2) were isolated from the African medicinal plant Momordica balsamina L. Karavoates B (3) and D (4) were synthesized by diacylation of 2 with acetic and propionic anhydrides, respectively.

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African Institute for Ecological Suppression of Malaria

August 31, 2015 - 13:42 -- William Jobin

I invite you to help me imagine a solid and realistic approach to malaria control in Africa, rather than continuing our criticism of the current poorly focussed and unsustainable attempts by WHO, RBM and the US PMI. I think we need a permanent Institute where African malaria people can develop, implement and expand anti-malarial measures. Because the current emphasis on drugs, biocides and bednets is inherently unsustainable, let us take a more sensible and rational approach which utilizes ecological changes.

Genetic evidence for contribution of human dispersal to the genetic diversity of EBA-175 in Plasmodium falciparum

August 5, 2015 - 09:06 -- Open Access
Author(s): 
Yoshiki Yasukochi, Izumi Naka, Jintana Patarapotikul, Hathairad Hananantachai, Jun Ohashi
Reference: 
Malaria Journal 2015, 14:293 (1 August 2015)

Plasmodium falciparum eba-175 genetic diversity appeared to increase following the exodus of Asian ancestors from Africa.

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Blue marble health and “the big three diseases”: HIV/AIDS, tuberculosis, and malaria

July 21, 2015 - 16:41 -- Open Access
Author(s): 
Peter J. Hotez
Reference: 
Microbes and Infection, Volume 17, Issue 8, August 2015, Pages 539-541

An analysis of information released by the World Health Organization reveals that the concepts of blue marble health extend beyond neglected tropical diseases to also include “the big three diseases”: HIV/AIDS, tuberculosis, and malaria.

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Past and new challenges for malaria control and elimination: the role of operational research for innovation in designing interventions

July 17, 2015 - 10:39 -- Open Access
Author(s): 
Philippe Guyant, Vincent Corbel, Nicholas White, et al.
Reference: 
Malaria Journal 2015, 14:279 (17 July 2015)

This meeting report presents the outcomes of a workshop held in Bangkok on December 1st 2014, where the following challenges were discussed: the threat of resistance to artemisinin and artemisinin-based combination therapy in the Greater Mekong Sub-region (GMS) and in Africa; access to treatment for most at risk and hard to reach population; insecticide resistance, residual and outdoors transmission.

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