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Africa

Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine

May 9, 2017 - 15:45 -- Open Access
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Author(s): 
Brian Greenwood, Alassane Dicko, Daniel Chandramohan, et al.
Reference: 
Malaria Journal 2017 16:182, 2 May 2017

In many parts of the African Sahel and sub-Sahel, where malaria remains a major cause of mortality and morbidity, transmission of the infection is highly seasonal.

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Village planning for intrinsic prevention of malaria transmission

March 25, 2017 - 19:51 -- William Jobin

The Eltahir group at MIT has recently published a pioneering study which makes it possible to plan resettlement and new villages in ways which will permanently minimize malaria transmission, because of ecological design. This is especially valuable for engineers planning resettlement communities related to large reservoirs and irrigation systems.

Such safe designs reduce the need for the ephemeral methods based on drugs, bednets and insecticides.

The report is:

Geographical distributions of African malaria vector sibling species and evidence for insecticide resistance

February 22, 2017 - 14:20 -- Open Access
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Author(s): 
Antoinette Wiebe, Joshua Longbottom, Catherine L. Moyes, et al.
Reference: 
Malaria Journal 2017 16:85, 20 February 2017

Sibling species display important variability in their geographical distributions and the most important malaria vector sibling species in Africa have been mapped here for the first time.

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What will become of the US Malaria Initiative now?

January 25, 2017 - 13:51 -- William Jobin
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Since the Trump administration came into office, there are real uncertainties about the long-standing US Presidential Malaria Initiaitive (the PMI), which I helped start in 2005. Firstly, the Administrator Tim Ziemer, who has given the Initiative real stability for 8 years, has resigned. Secondly it appears that the very conservative Newt Gingrich will take over USAID which funds the PMI within the US State Department. Gingrich is opposed to USAID and might dismantle it. Fortunately the new US Secty of State Rex Tillerson has gone on record as favoring the health programs of USAID.

Incidence and admission rates for severe malaria and their impact on mortality in Africa

January 4, 2017 - 17:48 -- Open Access
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Author(s): 
Flavia Camponovo, Caitlin A. Bever, Katya Galactionova, Thomas Smith and Melissa A. Penny
Reference: 
Malaria Journal 2017 16:1, 3 January 2017

The model-based methods proposed here offer a standardized approach to estimate the numbers of severe malaria cases and deaths based on national level reporting, allowing for coverage of both curative and preventive interventions.

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CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature

December 22, 2016 - 12:38 -- Open Access
Author(s): 
Phillip A. Swanson II, Geoffrey T. Hart, Dorian B. McGavern, et al.
Reference: 
PLoS Pathog 12(12): e1006022

Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that results in thousands of deaths each year, mostly in African children.

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More people caught in the Immunity Trap in 2016

December 20, 2016 - 21:15 -- William Jobin

The WHO Malaria Report for 2016 mentions an alarming increase in the number of people no longer receiving protection from indoor spraying, and thus an increase in the number of people in endemic areas who have lost their immunity, due to previous intense spraying. For Africa, 10.5% of the populations were covered in 2010, but this had dropped to 5.7% by end of 2016.

Eltahir Group predicts little adverse impact of climate change on malaria in West Africa

December 19, 2016 - 22:08 -- William Jobin

It is important to note a recent report on the predicted impact of climate change on malaria in West Africa, by Teresa K. Yamana, Arne Bomblies and Elfatih A. B. Eltahir. 2016 in the Journal Nature, entitled "Climate change unlikely to increase malaria burden in West Africa." doi:10.1038/nclimate3085

Eltahir research group at MIT on African malaria

December 7, 2016 - 21:21 -- William Jobin

I recommend the following recent publication for your reading on african malaria : Endo and Eltahir Malar J (2016) 15:578 DOI 10.1186/s12936-016-1633-7. The report is 'Environmental determinants of malaria transmission in African villages' by Noriko Endo and Elfatih A. B. Eltahir. You should also take a look at all the preceding publications of the Eltahir research group at MIT, which you can find if you look up the Eltahir research group on the web.

Environmental determinants of malaria transmission in African villages

December 7, 2016 - 17:05 -- Open Access
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Author(s): 
Noriko Endo and Elfatih A. B. Eltahir
Reference: 
Malaria Journal 2016 15:578, 1 December 2016

The predictive theory is useful in measuring malaria transmission potential, and it can also provide guidelines on how to plan the layout of human habitats in order to prevent endemic malaria.

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