We evaluated markers of sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum among 254 returned migrant workers in China from Africa from 2013 to 2016.
IN 30 SECONDS: There is no doubt that bed nets, insecticides, medicines and diagnostics will deliver significant successes against malaria in the short-term. But as major international partners continue prioritizing the commodity-based approach, African governments should be building the necessary resilience in affected communities. Countries should ensure safe houses and physical environments so that exposure to mosquito bites is minimized, strengthen health systems to identify and treat new malaria cases, expand access to health education in schools and households, and improve household economies and food security so that competing priorities are addressed. This needs to be a long-term strategy, paid for by domestic funding, subsidies, tax rebates or other innovative financing mechanisms – for example a ten-dollar malaria levy paid by international travelers visiting endemic countries. This way, the affected countries can better avoid malaria deaths and sickness, or rebounds of transmission, which currently place such a strain on national health outcomes and development.
The population pharmacokinetic models developed for both AS/DHA and MQ showed a large variability in drug exposure in the investigated African paediatric population.
In this study SMC for children under 10 years of age given over 5 months was feasible, well tolerated, and effective in preventing malaria episodes, and reduced the prevalence of parasitaemia and anaemia. SMC with CCM achieved high coverage and ensured children with malaria were promptly treated with artemether-lumefantrine.
Accurate, low-cost, reagent-free screening of mosquito populations enabled by NIRS could revolutionize surveillance and elimination strategies for the most important human malaria parasite in its primary African vector species.
Prospective studies of travellers with different levels of prior exposure, returning to malaria-free countries with Plasmodium infection, offer a unique opportunity to investigate the kinetics and composition of the antibody response after natural infection.
These findings call into question the appropriateness of current methods of assessing host preferences among disease vectors and have important implications for strategizing vector control.
According to the World Health Organization (WHO), Plasmodium falciparum malaria during pregnancy is responsible for deleterious consequences for the mother and her child.
Prompted by the 20th anniversary of Roll Back Malaria, the author recalls hypotheses concerning a major new initiative to control malaria in Africa put forward by WHO AFRO and the World Bank in 1996.
This study demonstrated that having enough ITNs in the household increases level of use and decreases existing disparities between age and gender groups. ITN distribution via mass campaigns and continuous distribution channels should be enhanced as needed to ensure that households have enough ITNs for all members, including men and school-aged children.