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Africa

NOT Open Access | Mutation Profile of pfdhfr and pfdhps in Plasmodium falciparum among Returned Chinese Migrant Workers from Africa

April 30, 2019 - 15:18 -- NOT Open Access
Author(s): 
Chao Xu, Hui Sun, Qingkuan Wei, Jin Li, Ting Xiao, Xiangli Kong, Yongbin Wang, Guihua Zhao, Longjiang Wang, Gongzhen Liu, Ge Yan, Bingcheng Huang and Kun Yin
Reference: 
Antimicrob. Agents Chemother. April 2019 63:e01927-18

We evaluated markers of sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum among 254 returned migrant workers in China from Africa from 2013 to 2016.

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Insecticides, bednets and medicines may slow malaria down, but real progress requires a more holistic approach

April 25, 2019 - 10:06 -- Fredros Okumu
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IN 30 SECONDS: There is no doubt that bed nets, insecticides, medicines and diagnostics will deliver significant successes against malaria in the short-term. But as major international partners continue prioritizing the commodity-based approach, African governments should be building the necessary resilience in affected communities. Countries should ensure safe houses and physical environments so that exposure to mosquito bites is minimized, strengthen health systems to identify and treat new malaria cases, expand access to health education in schools and households, and improve household economies and food security so that competing priorities are addressed. This needs to be a long-term strategy, paid for by domestic funding, subsidies, tax rebates or other innovative financing mechanisms – for example a ten-dollar malaria levy paid by international travelers visiting endemic countries. This way, the affected countries can better avoid malaria deaths and sickness, or rebounds of transmission, which currently place such a strain on national health outcomes and development.

Population pharmacokinetics and pharmacodynamics of the artesunate–mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children

April 22, 2019 - 12:28 -- Open Access
Author(s): 
Monia Guidi, Thomas Mercier, Manel Aouri, Laurent A. Decosterd, Chantal Csajka, Bernhards Ogutu, Gwénaëlle Carn and Jean-René Kiechel
Reference: 
Malaria Journal 2019 18:139, 18 April 2019

The population pharmacokinetic models developed for both AS/DHA and MQ showed a large variability in drug exposure in the investigated African paediatric population.

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Seasonal malaria chemoprevention combined with community case management of malaria in children under 10 years of age, over 5 months, in south-east Senegal: A cluster-randomised trial

March 28, 2019 - 16:07 -- Open Access
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Author(s): 
Jean Louis A. Ndiaye, Youssoupha Ndiaye, Paul Milligan, et al.
Reference: 
PLoS Med 16(3): e1002762

 

In this study SMC for children under 10 years of age given over 5 months was feasible, well tolerated, and effective in preventing malaria episodes, and reduced the prevalence of parasitaemia and anaemia. SMC with CCM achieved high coverage and ensured children with malaria were promptly treated with artemether-lumefantrine.

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Detection of Plasmodium falciparum infected Anopheles gambiae using near-infrared spectroscopy

March 20, 2019 - 15:47 -- Open Access
Author(s): 
Marta F. Maia, Melissa Kapulu, Michelle Muthui, Martin G. Wagah, Heather M. Ferguson, Floyd E. Dowell, Francesco Baldini and Lisa-Ranford Cartwright
Reference: 
Malaria Journal 2019 18:85, 19 March 2019

Accurate, low-cost, reagent-free screening of mosquito populations enabled by NIRS could revolutionize surveillance and elimination strategies for the most important human malaria parasite in its primary African vector species.

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Antibody responses to merozoite antigens after natural Plasmodium falciparum infection: kinetics and longevity in absence of re-exposure

February 9, 2019 - 18:45 -- Open Access
Author(s): 
Victor Yman, Michael T. White, Muhammad Asghar, Christopher Sundling, Klara Sondén, Simon J. Draper, Faith H. A. Osier and Anna Färnert
Reference: 
BMC Medicine 201917:22

Prospective studies of travellers with different levels of prior exposure, returning to malaria-free countries with Plasmodium infection, offer a unique opportunity to investigate the kinetics and composition of the antibody response after natural infection.

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Using the human blood index to investigate host biting plasticity: a systematic review and meta-regression of the three major African malaria vectors

January 2, 2019 - 15:19 -- Open Access
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Author(s): 
James Orsborne, Luis Furuya-Kanamori, Laith Yakob, et al.
Reference: 
Malaria Journal 2018 17:479, 18 December 2018

These findings call into question the appropriateness of current methods of assessing host preferences among disease vectors and have important implications for strategizing vector control.

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Has doxycycline, in combination with anti-malarial drugs, a role to play in intermittent preventive treatment of Plasmodium falciparum malaria infection in pregnant women in Africa?

December 27, 2018 - 15:22 -- Open Access
Author(s): 
Tiphaine Gaillard, Manon Boxberger, Marylin Madamet and Bruno Pradines
Reference: 
Malaria Journal 2018 17:469, 14 December 2018

According to the World Health Organization (WHO), Plasmodium falciparum malaria during pregnancy is responsible for deleterious consequences for the mother and her child.

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Roll Back Malaria: an historical footnote

November 21, 2018 - 14:50 -- Open Access
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Author(s): 
Sir Richard Feachem
Reference: 
Malaria Journal 2018 17:433, 19 November 2018

Prompted by the 20th anniversary of Roll Back Malaria, the author recalls hypotheses concerning a major new initiative to control malaria in Africa put forward by WHO AFRO and the World Bank in 1996.

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Age and gender trends in insecticide-treated net use in sub-Saharan Africa: a multi-country analysis

November 17, 2018 - 08:36 -- Open Access
Author(s): 
Bolanle Olapeju, Ifta Choiriyyah, Hannah Koenker, et al.
Reference: 
Malaria Journal 2018 17:423

This study demonstrated that having enough ITNs in the household increases level of use and decreases existing disparities between age and gender groups. ITN distribution via mass campaigns and continuous distribution channels should be enhanced as needed to ensure that households have enough ITNs for all members, including men and school-aged children.

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