Southeast Asia

A dual colour fluorescence in situ hybridization (FISH) assay for identifying the zoonotic malaria parasite Plasmodium knowlesi with a potential application for the specific diagnosis of knowlesi malaria in peripheral-level laboratories of Southeast Asia

Tags:

malaria, Plasmodium knowlesi, zoonotic malaria

Author(s):

Jyotsna Shah, Akhila Poruri, Olivia Mark, Urmila Khadilka, Franziska Mohring, Robert W. Moon and Ranjan Ramasamy

Reference:

Shah et al. Parasites & Vectors (2017) 10:342

Plasmodium knowlesi is primarily responsible for zoonotic malaria in several Southeast Asian countries. Precise identification of the parasite in the blood of patients presently relies on an expensive and elaborate PCR procedure because microscopic examination of blood and other available field identification techniques lack adequate specificity.

Continent:

Southeast Asia

Low Levels of Polymorphisms and No Evidence for Diversifying Selection on the Plasmodium knowlesi Apical Membrane Antigen 1 Gene

Tags:

Plasmodium knowlesi

Author(s):

Bart W. Faber, Khamisah Abdul Kadir, Roberto Rodriguez-Garcia, Edmond J. Remarque, Frederick A. Saul, Brigitte Vulliez-Le Normand, Graham A. Bentley, Clemens H. M. Kocken, Balbir Singh

Reference:

PLoS ONE 10(4): e012440

Infection with Plasmodium knowlesi, a zoonotic primate malaria, is a growing human health problem in Southeast Asia.

Continent:

Southeast Asia

The Plasmodium vivax in China: decreased in local cases but increased imported cases from Southeast Asia and Africa

Tags:

vivax malaria, plasmodium falciparum

Author(s):

Jun Feng, Huihui Xiao, Li Zhang, He Yan, Xinyu Feng, Wen Fang, Zhigui Xia

Reference:

Scientific Reports 5: 8847

Herein we have clarified the trend of P. vivax in China from 2004–2012, and made some analysis for the differences of imported vivax back from different regions. There are significantly different of P. vivax between Southeast Asia and Africa, also the difference was observed for different regions in Africa.

Continent:

Southeast Asia

Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

Tags:

plasmodium falciparum, malaria

Author(s):

Shannon Takala-Harrison, Christopher G. Jacob, Christopher V. Plowe, et al.

Reference:

J Infect Dis. (2015) 211 (5): 670-679

While we found some evidence of spreading resistance, there was no evidence of resistance moving westward from Cambodia into Myanmar.

Continent:

Southeast Asia

Global malaria connectivity through air travel

Tags:

malaria

Author(s):

Huang Z, Tatem AJ

Reference:

Malaria Journal 2013, 12:269 (2 August 2013)

The research presented here provides an initial effort to quantify and analyse the connectivity that exists across the malaria-endemic world through air travel, and provide a basic assessment of the risks it results in for movement of infections.

Continent:

Southeast Asia

Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia

Tags:

malaria, plasmodium falciparum

Author(s):

Shannon Takala-Harrison, Taane G. Clark, Christopher V. Plowe, et al.

Reference:

PNAS January 2, 2013 vol. 110 no. 1 240-245

The recent emergence of artemisinin-resistant Plasmodium falciparum malaria in western Cambodia could threaten prospects for malaria elimination.

Continent:

Southeast Asia

Country:

Cambodia

Medical Condition:

artemisinin-resistant

Not Open Access | Population genetics of the malaria vector Anopheles aconitus in China and Southeast Asia.

Author(s):

Bin Chen, Ralph E. Harbach, Catherine Walton, Zhengbo He, DaibinZhong, Guiyun Yan, Roger K. Butlin

Reference:

Infection, Genetics and Evolution, Volume 12, Issue 8, December 2012, Pages 1958-1967

Anopheles aconitus is a well-known vector of malaria and is broadly distributed in the Oriental Region, yet there is no information on its population genetic characteristics. In this study, the genetic differentiation among populations was examined using 140 mtDNA COII sequences from 21 sites throughout Southern China, Myanmar, Vietnam, Thailand, Laos and Sri Lanka. The population in Sri Lanka has characteristic rDNA D3 and ITS2, mtDNA COII and ND5 haplotypes, and may be considered a distinct subspecies.

Continent:

Country:

Medical Condition:

NOT Open Access | Review: Poor-quality antimalarial drugs in southeast Asia and sub-Saharan Africa

Author(s):

Gaurvika ML Nayyar, Joel G Breman, Paul N Newton, James Herrington

Reference:

The Lancet Infectious Diseases, Volume 12, Issue 6, June 2012, Pages 488-496

MalariaWorld We reviewed published and unpublished studies reporting chemical analyses and assessments of packaging of antimalarial drugs.

Continent:

Southeast Asia

sub-saharan Africa

Medical Treatment:

antimalarial

The Medicinal Chemistry of Novel Approaches for the Treatment of Malaria

Author(s):

J. Meyers, Marvin

Reference:

Current Topics in Medicinal Chemistry, Volume 12, Number 5, March 2012 , pp. 371-372(2)

MalariaWorld The introduction of artemisinin and artemisinin combination therapies (ACTs) in 2005 has begun to reverse the trend. While this is a good sign, there have been reports of resistance to artemisinin in Southeast Asia [2].

Continent:

Medical Condition:

Medical Treatment:

Open Access | A call to action: addressing the challenge of artemisinin-resistant malaria

Author(s):

Stephen P Kachur, John R MacArthur and Laurence Slutsker

Reference:

Expert Review of Anti-infective Therapy, Volume 8

Malaria control programs and their donor partners across the endemic world should urgently revitalize efforts to characterize and track potentially resistant parasites, especially where they are investing heavily in rolling out access to ACTs.

Continent:

Africa

Southeast Asia

Medical Condition:

Plasmodium falciparum

Medical Treatment:

Artemisinin

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