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Southeast Asia

A dual colour fluorescence in situ hybridization (FISH) assay for identifying the zoonotic malaria parasite Plasmodium knowlesi with a potential application for the specific diagnosis of knowlesi malaria in peripheral-level laboratories of Southeast Asia

May 30, 2018 - 07:08 -- Open Access
Author(s): 
Jyotsna Shah, Akhila Poruri, Olivia Mark, Urmila Khadilka, Franziska Mohring, Robert W. Moon and Ranjan Ramasamy
Reference: 
Shah et al. Parasites & Vectors (2017) 10:342

Plasmodium knowlesi is primarily responsible for zoonotic malaria in several Southeast Asian countries. Precise identification of the parasite in the blood of patients presently relies on an expensive and elaborate PCR procedure because microscopic examination of blood and other available field identification techniques lack adequate specificity. 

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Low Levels of Polymorphisms and No Evidence for Diversifying Selection on the Plasmodium knowlesi Apical Membrane Antigen 1 Gene

April 27, 2015 - 13:15 -- Open Access
Author(s): 
Bart W. Faber, Khamisah Abdul Kadir, Roberto Rodriguez-Garcia, Edmond J. Remarque, Frederick A. Saul, Brigitte Vulliez-Le Normand, Graham A. Bentley, Clemens H. M. Kocken, Balbir Singh
Reference: 
PLoS ONE 10(4): e012440

Infection with Plasmodium knowlesi, a zoonotic primate malaria, is a growing human health problem in Southeast Asia.

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The Plasmodium vivax in China: decreased in local cases but increased imported cases from Southeast Asia and Africa

March 6, 2015 - 14:13 -- Open Access
Author(s): 
Jun Feng, Huihui Xiao, Li Zhang, He Yan, Xinyu Feng, Wen Fang, Zhigui Xia
Reference: 
Scientific Reports 5: 8847

Herein we have clarified the trend of P. vivax in China from 2004–2012, and made some analysis for the differences of imported vivax back from different regions. There are significantly different of P. vivax between Southeast Asia and Africa, also the difference was observed for different regions in Africa.

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Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

February 16, 2015 - 15:47 -- Open Access
Author(s): 
Shannon Takala-Harrison, Christopher G. Jacob, Christopher V. Plowe, et al.
Reference: 
J Infect Dis. (2015) 211 (5): 670-679

While we found some evidence of spreading resistance, there was no evidence of resistance moving westward from Cambodia into Myanmar.

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Global malaria connectivity through air travel

August 5, 2013 - 17:54 -- Open Access
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Author(s): 
Huang Z, Tatem AJ
Reference: 
Malaria Journal 2013, 12:269 (2 August 2013)
MalariaWorld

The research presented here provides an initial effort to quantify and analyse the connectivity that exists across the malaria-endemic world through air travel, and provide a basic assessment of the risks it results in for movement of infections.

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Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia

January 4, 2013 - 07:03 -- Open Access
Author(s): 
Shannon Takala-Harrison, Taane G. Clark, Christopher V. Plowe, et al.
Reference: 
PNAS January 2, 2013 vol. 110 no. 1 240-245
MalariaWorld

The recent emergence of artemisinin-resistant Plasmodium falciparum malaria in western Cambodia could threaten prospects for malaria elimination.

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Not Open Access | Population genetics of the malaria vector Anopheles aconitus in China and Southeast Asia.

November 12, 2012 - 05:37 -- NOT Open Access
Author(s): 
Bin Chen, Ralph E. Harbach, Catherine Walton, Zhengbo He, DaibinZhong, Guiyun Yan, Roger K. Butlin
Reference: 
Infection, Genetics and Evolution, Volume 12, Issue 8, December 2012, Pages 1958-1967
MalariaWorld

Anopheles aconitus is a well-known vector of malaria and is broadly distributed in the Oriental Region, yet there is no information on its population genetic characteristics. In this study, the genetic differentiation among populations was examined using 140 mtDNA COII sequences from 21 sites throughout Southern China, Myanmar, Vietnam, Thailand, Laos and Sri Lanka. The population in Sri Lanka has characteristic rDNA D3 and ITS2, mtDNA COII and ND5 haplotypes, and may be considered a distinct subspecies.

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NOT Open Access | Review: Poor-quality antimalarial drugs in southeast Asia and sub-Saharan Africa

May 23, 2012 - 12:54 -- Patrick Sampao
Author(s): 
Gaurvika ML Nayyar, Joel G Breman, Paul N Newton, James Herrington
Reference: 
The Lancet Infectious Diseases, Volume 12, Issue 6, June 2012, Pages 488-496

MalariaWorldWe reviewed published and unpublished studies reporting chemical analyses and assessments of packaging of antimalarial drugs.

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The Medicinal Chemistry of Novel Approaches for the Treatment of Malaria

February 22, 2012 - 14:16 -- Patrick Sampao
Author(s): 
J. Meyers, Marvin
Reference: 
Current Topics in Medicinal Chemistry, Volume 12, Number 5, March 2012 , pp. 371-372(2)

MalariaWorldThe introduction of artemisinin and artemisinin combination therapies (ACTs) in 2005 has begun to reverse the trend. While this is a good sign, there have been reports of resistance to artemisinin in Southeast Asia [2].

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Open Access | A call to action: addressing the challenge of artemisinin-resistant malaria

April 9, 2010 - 13:59 -- Patrick Sampao
Author(s): 
Stephen P Kachur, John R MacArthur and Laurence Slutsker
Reference: 
Expert Review of Anti-infective Therapy, Volume 8

Malaria control programs and their donor partners across the endemic world should urgently revitalize efforts to characterize and track potentially resistant parasites, especially where they are investing heavily in rolling out access to ACTs.

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