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NOT Open Access | Development of piperazine-based hydroxamic acid inhibitors against falcilysin, an essential malarial protease

May 9, 2018 - 16:20 -- NOT Open Access
Author(s): 
Jeffrey P. Chance, Hannah Fejzic, Jeremy P. Mallari, et al.
Reference: 
Bioorganic & Medicinal Chemistry Letters Volume 28, Issue 10, 1 June 2018, Pages 1846-1848

The human parasite Plasmodium falciparum kills an estimated 445,000 people a year, with the most fatalities occurring in African children.

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Not Open Access | Blood feeding induces hemocyte proliferation and activation in the African malaria mosquito, Anopheles gambiae Giles

May 6, 2014 - 17:11 -- NOT Open Access
Author(s): 
William B. Bryant and Kristin Michel
Reference: 
The Journal of Experimental Biology , J Exp Biol 217, 1238-1245 , April 15, 2014

Taken together, this study demonstrates that the normal physiological process of a blood meal activates the innate immune response in mosquitoes. This process is likely in part regulated by Ras-MAPK signaling, highlighting a novel mechanistic link between blood feeding and immunity.

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NOT Open Access | Identification and characterization of two chitin synthase genes in African malaria mosquito, Anopheles gambiae

August 15, 2012 - 07:21 -- Kabogo Ndegwa
Author(s): 
Xin Zhang, Jianzhen Zhang, Yoonseong Park, Kun Yan Zhu
Reference: 
Insect Biochemistry and Molecular Biology, Volume 42, Issue 9, September 2012, Pages 674–682

MalariaWorldChitin synthase (CHS) represents an attractive target site for combating insect pests as insect growth and development are strictly dependent on precisely tuned chitin biosynthesis and this pathway is absent in humans and other vertebrates.

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Thermal limits of wild and laboratory strains of two African malaria vector species, Anopheles arabiensis and Anopheles funestus

July 13, 2012 - 10:26 -- Patrick Sampao
Author(s): 
Lyons CL, Coetzee M, Terblanche JS, Chown SL
Reference: 
Malaria Journal 2012, 11:226 (6 July 2012)

MalariaWorldThese findings and the greater tolerance of females to thermal extremes may have significant implications for future malaria transmission, especially in areas of current seasonal transmission and in areas on the boundaries of current vector distribution.

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Restricted | Next Generation Sequencing to Detect Variation in the Plasmodium falciparum Circumsporozoite Protein

May 3, 2012 - 13:53 -- Patrick Sampao
Author(s): 
Kavita Gandhi, Mahamadou A. Thera, Drissa Coulibaly, Karim Traoré, Ando B. Guindo, Ogobara K. Doumbo, Shannon Takala-Harrison and Christopher V. Plowe
Reference: 
Am J Trop Med Hyg 2012 86:775-781

MalariaWorldIn this study, 454, a next generation sequencing technology, was evaluated as a method for assessing diversity in these regions. Portions of the circumsporozoite gene (cs) were sequenced both by 454 and Sanger sequencing from samples collected in a study in Bandiagara, Mali.

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Open Access | Commentary: Relegating malaria resurgences to history

April 26, 2012 - 08:59 -- Patrick Sampao
Author(s): 
Newman RD
Reference: 
Malaria Journal 2012, 11:123 (24 April 2012)

MalariaWorldThe review by Cohen et al. suggests one possible future if such investment is not made. However, with sufficient support, malaria resurgences can be relegated to history.

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Lethal and Sublethal Effects of Avermectin/Milbemycin Parasiticides on the African Malaria Vector, Anopheles arabiensis

March 13, 2012 - 14:58 -- Patrick Sampao
Author(s): 
Megan L. Fritz, Edward D. Walker and James R. Miller
Reference: 
Journal of Medical Entomology 49(2):326-331. 2012

MalariaWorldThese results suggest that cattle treated with ivermectin or eprinomectin in the prescribed range of low dosages as parasiticides have blood toxic to zoophilic malaria vectors.

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Open Access | First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

October 21, 2011 - 13:44 -- Patrick Sampao
Author(s): 
Selidji Todagbe Agnandji, M.D., M.P.H., Bertrand Lell, M.D., Solange Solmeheim Soulanoudjingar, M.D., et al.
Reference: 
October 18, 2011 (10.1056/NEJMoa1102287)

MalariaWorldThe primary end point of the analysis was vaccine efficacy against clinical malaria during the 12 months after vaccination in the first 6000 children 5 to 17 months of age at enrollment who received all three doses of vaccine according to protocol. After 250 children had an episode of severe malaria, we evaluated vaccine efficacy against severe malaria in both age categories.

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Infection Intensity-Dependent Responses of Anopheles gambiae to the African Malaria Parasite Plasmodium falciparum

October 17, 2011 - 08:29 -- Patrick Sampao
Author(s): 
Antonio M. Mendes, Parfait H. Awono-Ambene, Sandrine E. Nsango, Anna Cohuet, Didier Fontenille, Fotis C. Kafatos, George K. Christophides, Isabelle Morlais, and Dina Vlachou
Reference: 
Infect. Immun., Nov 2011; 79: 4708 - 4715.

MalariaWorldThese data suggest that coadaptation between vectors and parasites may act to minimize the impact of infection on mosquito fitness by selectively suppressing specific functional classes of genes.

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Open Access | Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials

August 19, 2011 - 10:33 -- Patrick Sampao
Author(s): 
Carter N, Pamba A, Duparc S, Waitumbi JN
Reference: 
Malaria Journal 2011, 10:241 (17 August 2011)

Study participants, aged >1 year, with microscopically confirmed uncomplicated Plasmodium falciparum malaria, and haemoglobin 70 g/L or haematocrit 25%, were recruited into two clinical trials conducted in six African countries (Burkina Faso, Ghana, Kenya, Nigeria, Tanzania, Mali).

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