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Kisumu

Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial.

April 28, 2018 - 15:33 -- Open Access
Author(s): 
Smit MR, Ochomo E, Ter Kuile FO, et al.
Reference: 
Lancet Infect Dis. 2018 Mar 27. pii: S1473-3099(18)30163-4.

Ivermectin has captured the imagination of a small group of global health scientists as one approach to solving the problem of residual transmission of malaria. This old, so-called wonder drug—an endectocide that targets both endoparasites and ectoparasites—was originally identified as a natural substance by Satoshi Ōmura of Kitasato Institute. The drug was further developed by William Campbell of Merck Labs as a potent anthelmintic, originally for use in veterinary health and targeting more than 20 species of helminth.

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Open Access | Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya

November 26, 2010 - 10:15 -- Kabogo Ndegwa
Author(s): 
Spalding MD, Eyase FL, Akala HM, Bedno SA, Prigge ST, Coldren RL, Moss WJ, Waters NC
Reference: 
Malaria Journal 2010, 9:338 (24 November 2010)

During the period in which SP was the first-line anti-malarial in Kenya, highly SP-resistant parasites emerged, including isolates harboring pfdhps mutations not previously observed there.

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Significance of Travel to Rural Areas as a Risk Factor for Malarial Anemia in an Urban Setting

March 12, 2010 - 16:43 -- Ingeborg van Schayk
Author(s): 
Jose G. Siri, Mark L. Wilson, Susan Murray, Daniel H. Rosen, John M. Vulule, Laurence Slutsker, AND Kim A. Lindblade
Reference: 
Am J Trop Med Hyg 2010;82 391-397

Control of severe malaria in an urban setting may be complicated by Plasmodium infections acquired elsewhere. Epidemiologic studies of urban malaria in low transmission settings should take travel history into account.

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