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artemisinin

Cost-effectiveness analysis of malaria rapid diagnostic test incentive schemes for informal private healthcare providers in Myanmar

March 4, 2015 - 14:49 -- Open Access
Author(s): 
Ingrid T Chen, Tin Aung, Hnin Thant, May Sudhinaraset, James G Kahn
Reference: 
Malaria Journal 2015, 14:55 (5 February 2015)

A decision tree was constructed in a spreadsheet to estimate the incremental cost-effectiveness ratios (ICERs) among four strategies: no intervention, simple subsidy, subsidy with financial incentives, and subsidy with IEC.

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In vitro synergistic effect of fluoroquinolone analogues in combination with artemisinin against Plasmodium falciparum; their antiplasmodial action in rodent malaria model

February 27, 2015 - 16:06 -- Open Access
Author(s): 
Drishti Agarwal, Manish Sharma, Sandeep K Dixit, Roshan K Dutta, Ashok K Singh, Rinkoo D Gupta, Satish K Awasthi
Reference: 
Malaria Journal 2015, 14:48 (5 February 2015)

Emergence of drug-resistant parasite strains has surfaced as a major obstacle in attempts to ameliorate malaria. Current treatment regimen of malaria relies on the concept of artemisinin-based combination therapy (ACT).

Not Open Access | Efficacy and Safety of the Mosquitocidal Drug Ivermectin to Prevent Malaria Transmission After Treatment: A Double-Blind, Randomized, Clinical Trial

January 14, 2015 - 18:12 -- NOT Open Access
Author(s): 
André Lin Ouédraogo, Guido J. H. Bastiaens, Teun Bousema, et al.
Reference: 
Clin Infect Dis. (2015) 60 (3): 357-365

Although we found no evidence that IVM reduced Plasmodium infection rates among surviving mosquitoes, the mosquitocidal effect of AL-IVM1 and AL-IVM2 resulted in 27% and 35% reductions, respectively, in estimated malaria transmission potential during the first week after initiation of treatment.

Artemisinin resistance – modelling the potential human and economic costs

December 5, 2014 - 07:33 -- Open Access
Author(s): 
Yoel Lubell, Arjen Dondorp, Philippe J Guérin, Tom Drake, Sylvia Meek, Elizabeth Ashley, Nicholas PJ Day, Nicholas J White, Lisa J White
Reference: 
Malaria Journal 2014, 13:452 (23 November 2014)

This analysis compares the health and economic consequences of two future scenarios occurring once artemisinin-based treatments are available with high coverage.

Enantiomerically pure amino-alcohol quinolines: in vitro anti-malarial activity in combination with dihydroartemisinin, cytotoxicity and in vivo efficacy in a Plasmodium berghei mouse model

October 30, 2014 - 16:34 -- Open Access
Author(s): 
Catherine Mullié, Nicolas Taudon, Camille Degrouas, Alexia Jonet, Aurélie Pascual, Patrice Agnamey, Pascal Sonnet
Reference: 
Malaria Journal 2014, 13:407 (16 October 2014)

The results obtained make those two (S)-amino-alcohol quinoline derivatives good candidates for the development of new artemisinin-based combination therapy (ACT), hopefully with fewer neurologic side effects than those currently marketed ACT, including MQ.

Genetic mutations in pfcrt and pfmdr1 at the time of artemisinin combination therapy introduction in South Pacific islands of Vanuatu and Solomon Islands

October 30, 2014 - 16:31 -- Open Access
Author(s): 
Karryn J Gresty, Karen-Ann Gray, Albino Bobogare, George Taleo, Jeffrey Hii, Lyndes Wini, Qin Cheng, Norman C Waters
Reference: 
Malaria Journal 2014, 13:406 (15 October 2014)

This study aims to provide baseline data on molecular markers (pfcrt and pfmdr1), along with the origins of pfcrt, prior to the introduction of AL.

The challenge of artemisinin resistance can only be met by eliminating Plasmodium falciparum malaria across the Greater Mekong subregion

August 15, 2014 - 15:15 -- Open Access
Author(s): 
Smith Gueye C, Newby G, Hwang J, Phillips AA, Whittaker M, MacArthur JR, Gosling RD, Feachem RG
Reference: 
Malaria Journal 2014, 13 :286 (27 July 2014)

This strategy is more efficient for several reasons. First, a subregional strategy is in line with current commitment to elimination and will build upon the existing national political support for elimination as well as enhancing collaboration among countries.

Artemisinin Combination Therapies and Malaria Parasite Drug Resistance: The Game Is Afoot

July 8, 2014 - 18:06 -- Open Access
Author(s): 
Steve M. Taylor and Jonathan J. Juliano
Reference: 
J Infect Dis. (2014) 210 (3): 335-337

To better detect these parasites, this phenotype has recently been associated with several polymorphisms in a novel parasite gene , and coordinated efforts are under way to track, contain, and eliminate these artemisinin-resistant parasites before their export from Southeast Asia.

Spatial distribution, work patterns, and perception towards malaria interventions among temporary mobile/migrant workers in artemisinin resistance containment zone

May 20, 2014 - 17:06 -- Open Access
Author(s): 
Khin Thet Wai, Myat Phone Kyaw, Tin Oo, PeThet Zaw, Myat Htut Nyunt, Moe Thida and Thar Tun Kyaw
Reference: 
BMC Public Health 2014, 14:463

Individual and household information was collected by structured interviews of 408 respondents from 39 aggregates, supplemented by 12 in-depth interviews of health care providers, authorities, volunteers, and employers. Data were analyzed by triangulating quantitative and qualitative data.

Were medicine quality and pharmaceutical management contributing factors in diminishing artemisinin efficacy in Guyana and Suriname?

April 7, 2014 - 16:49 -- Open Access
Author(s): 
Pribluda VS, Evans L, Barillas E, Marmion J, Lukulay P, Chang J
Reference: 
Malaria Journal 2014, 13 :77 (3 March 2014)

Data on malaria medicine quality and pharmaceutical management, generated in the context of the Amazon Malaria Initiative (AMI), was reviewed and discussed.

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