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anti-malarial drug

Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases

May 19, 2020 - 14:18 -- Open Access
Author(s): 
Cheong DHJ, Daniel Tan WS, Fred Wong WS, Tran T
Reference: 
Pharmacol Res. 2020 May 13:104901

Artemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the herb Artemisia annua. It has been used for centuries for the treatment of fever and chills, and has been recently approved for the treatment of malaria due to its endoperoxidase properties. Progressively, research has found that artemisinins displayed multiple pharmacological actions against inflammation, viral infections, and cell and tumour proliferation, making them effective against diseases. Moreover, it has displayed a relatively safe toxicity profile.

Rare mutations in Pfmdr1 gene of Plasmodium falciparum detected in clinical isolates from patients treated with anti-malarial drug in Nigeria

September 23, 2019 - 14:42 -- Open Access
Author(s): 
Abel O. Idowu, Wellington A. Oyibo, Sanjib Bhattacharyya, Manjeet Khubbar, Udoma E. Mendie, Violet V. Bumah, Carolyn Black, Joseph Igietseme and Anthony A. Azenabor
Reference: 
Malaria Journal 2019 18:319, 18 September 2019

Plasmodium falciparum, the deadliest causative agent of malaria, has high prevalence in Nigeria. Drug resistance causing failure of previously effective drugs has compromised anti-malarial treatment. On this basis, there is need for a proactive surveillance for resistance markers to the currently recommended artemisinin-based combination therapy (ACT), for early detection of resistance before it become widespread.

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Cellular engineering of Artemisia annua and Artemisia dubia with the rol ABC genes for enhanced production of potent anti-malarial drug artemisinin

May 6, 2016 - 17:55 -- Open Access
Author(s): 
Bushra Hafeez Kiani, John Suberu and Bushra Mirza
Reference: 
Malaria Journal 2016 15:252, 4 May 2016

Transformation of Artemisia sp. with rol ABC genes can lead to the increased production of artemisinin, which will help to meet the increasing demand of artemisinin because of its diverse pharmacological and anti-malarial importance.

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