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Efficacy and safety of dihydroartemisinin–piperaquine versus artemether–lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Ugandan children: a systematic review and meta-analysis of randomized control trials

April 7, 2021 - 12:49 -- Open Access
Dawit Getachew Assefa, Eden Dagnachew Zeleke, Delayehu Bekele, Hanna Amanuel Tesfahunei, Emnet Getachew, Michele Joseph and Tsegahun Manyazewal
Malaria Journal 2021 20:174, 1 April 2021

The emergence of artemisinin resistance in Southeast Asia and Plasmodium falciparum kelch13 propeller gene mutations in sub-Saharan African pose the greatest threat to global efforts to control malaria. This is a critical concern in Uganda, where artemisinin-based combination therapy (ACT) is the first-line treatment for uncomplicated falciparum. The objective of this study was to compare the efficacy and safety of dihydroartemisinin–piperaquine (DHA–PQ) and artemether–lumefantrine (AL) for the treatment of uncomplicated falciparum malaria in Ugandan children.

Infant sex modifies associations between placental malaria and risk of malaria in infancy

December 3, 2020 - 13:06 -- Open Access
Abel Kakuru, Michelle E. Roh, Prasanna Jagannathan, et al.
Malaria Journal 2020 19:449, 3 December 2020

Placental malaria (PM) has been associated with a higher risk of malaria during infancy. However, it is unclear whether this association is causal, and is modified by infant sex, and whether intermittent preventive treatment in pregnancy (IPTp) can reduce infant malaria by preventing PM.

A Randomized Comparison of Chloroquine Versus Dihydroartemisinin–Piperaquine for the Treatment of Plasmodium vivax Infection in Vietnam

April 12, 2016 - 16:34 -- Open Access
Phung Duc Thuan, Nguyen Thuy Nha Ca, Tran Tinh Hien, et al.
Am J Trop Med Hyg 2016 vol. 94 no. 4 879-885

All cases of recurrent parasitemia in the chloroquine arm occurred from day 33 onward, with corresponding whole blood chloroquine concentration lower than 100 ng/mL in all patients. Chloroquine thus remains efficacious for the treatment of P. vivax malaria in southern Vietnam, but DHA-PPQ provides more rapid symptomatic and parasitological recovery.

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