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Insecticide resistance in indoor and outdoor-resting Anopheles gambiae in Northern Ghana

September 1, 2020 - 10:24 -- Open Access
Majidah Hamid-Adiamoh, Alfred Amambua-Ngwa, Davis Nwakanma, Umberto D’Alessandro, Gordon A. Awandare and Yaw A. Afrane
Malaria Journal 2020 19:314, 31 August 2020

Selection pressure from continued exposure to insecticides drives development of insecticide resistance and changes in resting behaviour of malaria vectors. There is need to understand how resistance drives changes in resting behaviour within vector species. The association between insecticide resistance and resting behaviour of Anopheles gambiae sensu lato (s.l.) in Northern Ghana was examined.

Investigating the molecular basis of multiple insecticide resistance in a major malaria vector Anopheles funestus (sensu stricto) from Akaka-Remo, Ogun State, Nigeria

August 19, 2020 - 16:09 -- Open Access
Atoyebi SM, Tchigossou GM, Djouaka R, et al.
Parasit Vectors. 2020 Aug 18;13(1):423

Understanding the mechanisms used by Anopheles mosquitoes to survive insecticide exposure is key to manage existing insecticide resistance and develop more suitable insecticide-based malaria vector control interventions as well as other alternative integrated tools. To this regard, the molecular basis of permethrin, DDT and dieldrin resistance in Anopheles funestus (sensu stricto) at Akaka-Remo was investigated.

Association between maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) and risk of obesity in middle age

August 3, 2020 - 16:17 -- Open Access
La Merrill MA, Krigbaum NY, Cirillo PM, Cohn BA
Int J Obes (Lond). 2020 Aug; 44(8):1723-1732

Obesity is a malnourishment epidemic worldwide. A meta-analysis of prospective human studies across the world demonstrated a consistent positive association between maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyldichloroethylene (DDE) and children with obesity. The present study evaluates the association of maternal exposure to DDT and DDE with the risk of obesity in daughters during their mid-life in a prospective birth cohort with up to 53 years of follow-up.

Mapping trends in insecticide resistance phenotypes in African malaria vectors

June 29, 2020 - 16:10 -- Open Access
Hancock PA, Hendriks CJM, Tangena JA, Gibson H, Hemingway J, Coleman M, Gething PW, Cameron E, Bhatt S, Moyes CL
PLoS Biol. 2020 Jun 25; 18(6):e3000633

Mitigating the threat of insecticide resistance in African malaria vector populations requires comprehensive information about where resistance occurs, to what degree, and how this has changed over time. Estimating these trends is complicated by the sparse, heterogeneous distribution of observations of resistance phenotypes in field populations.

Erratum: "Prenatal Exposure to DDT and Pyrethroids for Malaria Control and Child Neurodevelopment: The VHEMBE Cohort, South Africa"

March 18, 2020 - 14:40 -- Open Access
Eskenazi B, An S, Rauch SA, Coker ES, Maphula A, Obida M, Crause M, Kogut KR, Bornman R, Chevrier J
Environ Health Perspect. 2020 Mar;128(3):39001

In this article, pyrethroid metabolite measurements were reported to be specific gravity-corrected. However, the statistical analyses were completed with uncorrected pyrethroid metabolite measurements. The results using specific gravity-corrected metabolite measurements are largely consistent with the uncorrected analyses.

An experimental hut study to quantify the effect of DDT and airborne pyrethroids on entomological parameters of malaria transmission

April 16, 2014 - 18:34 -- Open Access
Ogoma SB, Lorenz LM, Moore SJ, et al.
Malaria Journal 2014, 13 :131 (1 April 2014)

This study highlights that airborne pyrethroids and DDT affect a range of anopheline mosquito behaviours that are important parameters in malaria transmission, namely deterrence, irritancy/excito-repellency and blood-feeding inhibition.

DDT and pyrethroid resistance in Anopheles arabiensis from South Africa

August 12, 2013 - 19:03 -- Open Access
Nardini L, Christian RN, Coetzer N, Koekemoer LL
Parasites & Vectors 2013, 6:229 (8 August 2013)

In this study, the genetic basis of pyrethroid resistance in a selected laboratory strain of An. arabiensis from South Africa was investigated using a custom-made microarray, known as the An. gambiae detoxification chip.

Implications of bio-efficacy and persistence of insecticides when indoor residual spraying and longlasting insecticide nets are combined for malaria prevention

November 20, 2012 - 06:56 -- Open Access
Okumu FO, Chipwaza B, Madumla EP, Mbeyela E, Lingamba G, Moore J, Ntamatungro AJ, Kavishe DR, Moore SJ
Malaria Journal 2012, 11:378 (19 November 2012)

In bioassays where sufficient contact with treated surfaces is assured, LLINs and IRS kill high proportions of susceptible An. arabiensis mosquitoes, though these efficacies decay gradually for LLINs and rapidly for IRS.


Is the bednet era coming to an end?

June 22, 2012 - 12:47 -- Bart G.J. Knols

Whenever I teach on the history of malaria, I talk about the different time periods when certain ideas were fashionable and implemented, and then disappeared, and sometimes came back much later.

Take the 'chloroquine era'. Discovered by Bayer scientists in the early 1930s and saved millions of lives around the globe, followed by resistance popping up in SE Asia and Colombia in the late 1950s. Resistance spreading to Africa in the late 1970s, and its use now largely reduced. End of the 'chloroquine era'.

Time to give spatial repellency its rightful role in vector control

June 19, 2012 - 19:19 -- Bart G.J. Knols

The following Guest editorial was provided by Richard Tren, Kimberly Hess, and Donald Roberts.

Progress is being made against malaria. As reported by the World Health Organization (WHO), malaria cases have declined by more than 50% between 2000 and 2010, and malaria-specific mortality has declined by 26% [1].  These gains are mainly due to the use of insecticides to control disease-spreading insects (vector control) through insecticide-treated bednets and indoor residual spraying (IRS). Despite the importance of public health insecticides in vector control, there is very little appreciation and understanding of how insecticides actually work in disease prevention.


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