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Cell-traversal protein for ookinetes and sporozoites (CelTOS) formulated with potent TLR adjuvants induces high-affinity antibodies that inhibit Plasmodium falciparum infection in Anopheles stephensi

April 29, 2019 - 13:13 -- Open Access
Sakineh Pirahmadi, Sedigheh Zakeri, Akram A. Mehrizi, Navid D. Djadid, Abbas-Ali Raz, Jafar J. Sani, Ronak Abbasi and Zahra Ghorbanzadeh
Malaria Journal 2019 18:146, 24 April 2019

Plasmodium falciparum parasite is the most deadly species of human malaria, and the development of an effective vaccine that prevents P. falciparum infection and transmission is a key target for malarial elimination and eradication programmes. P. falciparum cell-traversal protein for ookinetes and sporozoites (PfCelTOS) is an advanced vaccine candidate. A comparative study was performed to characterize the immune responses in BALB/c mouse immunized with Escherichia coli-expressed recombinant PfCelTOS (rPfCelTOS) in toll-like receptor (TLR)-based adjuvants, CpG and Poly I:C alone or in combination (CpG + Poly I:C), followed by the assessment of transmission-reducing activity (TRA) of anti-rPfCelTOS antibodies obtained from different vaccine groups in Anopheles stephensi.

Medical Condition: 

Not Open Access | Plasmodium: Yet More Don’ts

February 9, 2019 - 18:51 -- NOT Open Access
Miles B. Markus
Trends in Parasitology, Letter| Volume 35, Issue 2, P101-102, February 01, 2019

Anopheline’ is both an adjective (‘anopheline mosquito’) and a noun. Don’t use an upper case ‘A’, except at the beginning of a sentence; and do not italicize the word as if it is a Latinized genus name.

Change in Anopheles richness and composition in response to artificial flooding during the creation of the Jirau hydroelectric dam in Porto Velho, Brazil

February 23, 2017 - 16:24 -- Open Access
Moreno S. Rodrigures, Elis P. Batista, Alexandre A. Silva, Fábio M. Costa, Verissimo A. S. Neto and Luiz Herman S. Gil
Malaria Journal 2017 16:87, 22 February 2017

The continual monitoring of these vectors during the late operational phase may be useful in order to understand how anophelines will behave in this area.

Draft Genomes of Anopheles cracens and Anopheles maculatus: Comparison of Simian Malaria and Human Malaria Vectors in Peninsular Malaysia

July 19, 2016 - 15:15 -- Open Access
Yee-Ling Lau, Wenn-Chyau Lee, Junhui Chen, Zhen Zhong, Jianbo Jian, Amirah Amir, Fei-Wen Cheong, Jia-Siang Sum, Mun-Yik Fong
PLoS ONE 11(6): e0157893

Anopheles cracens has been incriminated as the vector of human knowlesi malaria in peninsular Malaysia.


Pilot longitudinal mosquito surveillance study in the Danube Delta Biosphere Reserve and the first reports of Anopheles algeriensis Theobald, 1903 and Aedes hungaricus Mihályi, 1955 for Romania

April 26, 2016 - 16:10 -- Open Access
Török E, Tomazatos A, Lühken R, et al.
Parasites & Vectors 2016, 9 :196 (11 April 2016)

We initiated a longitudinal mosquito surveillance study with carbon dioxide-baited Heavy Duty Encephalitis Vector Survey traps at four sampling sites to analyse the spatio-temporal pattern of the (i) mosquito species composition and diversity, (ii) functional groups of mosquitoes (oviposition sites, overwintering stage, and number of generations), and (iii) the occurrence of potential West Nile virus (WNV) vectors.

Behaviour and molecular identification of Anopheles malaria vectors in Jayapura district, Papua province, Indonesia

April 8, 2016 - 17:07 -- Open Access
Brandy St. Laurent, Sukowati Supratman, Neil F. Lobo, et al.
Malaria Journal 2016 15:192, 8 April 2016

The vector composition in Papua, Indonesia is consistent with certain northern areas of PNG, but the behaviours of anophelines sampled in this region, such as early and indoor human biting of An. farauti 4, may enable them to act as major vectors of malaria.

Malaria incidence and entomological findings in an area targeted for a cluster-randomized controlled trial to prevent malaria in Ethiopia: results from a pilot study

March 10, 2016 - 17:19 -- Open Access
Taye Gari, Oljira Kenea, Bernt Lindtjørn, et al.
Malaria Journal 2016 15:145, 8 March 2016

This study showed a high variation in malaria incidence and Anopheles between kebeles.


Analysis of esterase enzyme activity in adults of the major malaria vector Anopheles funestus

March 10, 2016 - 13:44 -- Open Access
Dahan-Moss Y, Koekemoer L
Parasites & Vectors 2016, 9 :110 (27 February 2016)

The aim of this study was to analyse esterase activity levels at different ages during the life-span of adult Anopheles funestus Giles in order to better understand the complex biological processes in this species.

Bio-efficacy of new long-lasting insecticide-treated bed nets against Anopheles funestus and Anopheles gambiae from central and northern Mozambique

September 22, 2015 - 17:45 -- Open Access
Ana Abílio, Pelágio Marrune, Nilsa de Deus, Francisco Mbofana, Pedro Muianga, Ayubo Kampango
Malaria Journal 2015, 14:352 (17 September 2015)

The study shows evidence of considerable heterogeneity in both insecticide susceptibility and the level of bio-efficacy of commonly available types of LLINs against wild A. funestus and A. gambiae from Balama, Mocuba and Milange districts, located in north and centre of Mozambique.


Humans frequently exposed to a range of non-human primate malaria parasite species through the bites of Anopheles dirus mosquitoes in South-central Vietnam

July 21, 2015 - 16:44 -- Open Access
Maeno Y, Quang N, Culleton R, Kawai S, Masuda G, Nakazawa S, Marchand R
Parasites & Vectors 2015, 8 :376 (16 July 2015)

In this study we analysed the species composition of malarial sporozoites infecting the salivary glands of Anopheles dirus in order to determine their potential role as bridge vectors of Plasmodium parasites from monkeys to humans.



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