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Anopheles metabolic proteins in malaria transmission, prevention and control: a review

September 15, 2020 - 10:49 -- Open Access
Adedeji EO, Ogunlana OO, Fatumo S, Beder T, Ajamma Y, Koenig R, Adebiyi E
Parasit Vectors. 2020 Sep 10;13(1):465.

The increasing resistance to currently available insecticides in the malaria vector, Anopheles mosquitoes, hampers their use as an effective vector control strategy for the prevention of malaria transmission. Therefore, there is need for new insecticides and/or alternative vector control strategies, the development of which relies on the identification of possible targets in Anopheles. Some known and promising targets for the prevention or control of malaria transmission exist among Anopheles metabolic proteins.

A comprehensive gender-related secretome of Plasmodium berghei sexual stages

September 12, 2020 - 15:08 -- Open Access
Grasso F, Mochi S, Fratini F, Olivieri A, Currà C, Siden-Kiamos I, Deligianni E, Birago C, Picci L, Pizzi E, Pace T, Ponzi M
Mol Cell Proteomics. 2020 Sep 3:mcp.RA120.002212

Plasmodium, the malaria parasite, undergoes a complex life cycle alternating between a vertebrate host and a mosquito vector of the genus Anopheles. In red blood cells of the vertebrate host, Plasmodium multiplies asexually or differentiates into gamete precursors, the male and female gametocytes, responsible for parasite transmission. Sexual stage maturation occurs in the midgut of the mosquito vector, where male and female gametes egress from the host erythrocytes to fuse and form a zygote.

Differential contribution of Anopheles coustani and Anopheles arabiensis to the transmission of Plasmodium falciparum and Plasmodium vivax in two neighbouring villages of Madagascar

August 27, 2020 - 08:17 -- Open Access
Goupeyou-Youmsi J, Rakotondranaivo T, Puchot N, Peterson I, Girod R, Vigan-Womas I, Paul R, Ndiath MO, Bourgouin C
Parasit Vectors. 2020 Aug 26;13(1):430

Malaria is still a heavy public health concern in Madagascar. Few studies combining parasitology and entomology have been conducted despite the need for accurate information to design effective vector control measures. In a Malagasy region of moderate to intense transmission of both Plasmodium falciparum and P. vivax, parasitology and entomology have been combined to survey malaria transmission in two nearby villages.

Natural Wolbachia infection in field-collected Anopheles and other mosquito species from Malaysia

August 18, 2020 - 14:33 -- Open Access
Wong ML, Liew JWK, Wong WK, Pramasivan S, Mohamed Hassan N, Wan Sulaiman WY, Jeyaprakasam NK, Leong CS, Low VL, Vythilingam I
Parasit Vectors. 2020 Aug 12;13(1):414

The endosymbiont bacterium Wolbachia is maternally inherited and naturally infects some filarial nematodes and a diverse range of arthropods, including mosquito vectors responsible for disease transmission in humans. Previously, it has been found infecting most mosquito species but absent in Anopheles and Aedes aegypti. However, recently these two mosquito species were found to be naturally infected with Wolbachia. We report here the extent of Wolbachia infections in field-collected mosquitoes from Malaysia based on PCR amplification of the Wolbachia wsp and 16S rRNA genes.

Heparin Administered to Anopheles in Membrane Feeding Assays Blocks Plasmodium Development in the Mosquito

August 5, 2020 - 16:24 -- Open Access
Lantero E, Fernandes J, Aláez-Versón CR, Gomes J, Silveira H, Nogueira F, Fernàndez-Busquets X
Biomolecules. 2020 Aug 1;10(8):E1136

Innovative antimalarial strategies are urgently needed given the alarming evolution of resistance to every single drug developed against Plasmodium parasites. The sulfated glycosaminoglycan heparin has been delivered in membrane feeding assays together with Plasmodium berghei-infected blood to Anopheles stephensi mosquitoes.

Leveraging big data for public health: Mapping malaria vector suitability in Malawi with Google Earth Engine

August 5, 2020 - 16:15 -- Open Access
Frake AN, Peter BG, Walker ED, Messina JP
PLoS ONE 15(8): e0235697

In an era of big data, the availability of satellite-derived global climate, terrain, and land cover imagery presents an opportunity for modeling the suitability of malaria disease vectors at fine spatial resolutions, across temporal scales, and over vast geographic extents. Leveraging cloud-based geospatial analytical tools, we present an environmental suitability model that considers water resources, flow accumulation areas, precipitation, temperature, vegetation, and land cover. In contrast to predictive models generated using spatially and temporally discontinuous mosquito presence information, this model provides continuous fine-spatial resolution information on the biophysical drivers of suitability.

NOT Open Access | Male swarming aggregation pheromones increase female attraction and mating success among multiple African malaria vector mosquito species

August 5, 2020 - 14:33 -- NOT Open Access
Mozūraitis R, Hajkazemian M, Zawada JW, Szymczak J, Pålsson K, Sekar V, Biryukova I, Friedländer MR, Koekemoer LL, Baird JK, Borg-Karlson AK, Emami SN
Nat Ecol Evol. 2020 Aug 3

Accumulating behavioural data indicate that aggregation pheromones may mediate the formation and maintenance of mosquito swarms. However, chemical cues possibly luring mosquitoes to swarms have not been adequately investigated, and the likely molecular incitants of these complex reproductive behaviours remain unknown. Here we show that males of the important malaria vector species Anopheles arabiensis and An. gambiae produce and release aggregation pheromones that attract individuals to the swarm and enhance mating success.

Anopheles bionomics, insecticide resistance and malaria transmission in southwest Burkina Faso: A pre-intervention study

August 5, 2020 - 14:13 -- Open Access
Soma DD, Zogo BM, Somé A, Tchiekoi BN, et al.
PLoS ONE 15(8): e0236920

Twenty-seven villages were selected in southwest Burkina Faso to implement new vector control strategies in addition to long lasting insecticidal nets (LLINs) through a Randomized Controlled Trial (RCT). We conducted entomological surveys in the villages during the dry cold season (January 2017), dry hot season (March 2017) and rainy season (June 2017) to describe malaria vectors bionomics, insecticide resistance and transmission prior to this trial.

Quantifying flight aptitude variation in wild Anopheles gambiae in order to identify long-distance migrants

July 22, 2020 - 15:47 -- Open Access
Roy Faiman, Alpha S. Yaro, Tovi Lehmann, et al.
Malaria Journal 2020 19:263, 22 July 2020

In the West African Sahel, mosquito reproduction is halted during the 5–7 month-long dry season, due to the absence of surface waters required for larval development. However, recent studies have suggested that both Anopheles gambiae sensu stricto (s.s.) and Anopheles arabiensis repopulate this region via migration from distant locations where larval sites are perennial. Anopheles coluzzii engages in more regional migration, presumably within the Sahel, following shifting resources correlating with the ever-changing patterns of Sahelian rainfall. Understanding mosquito migration is key to controlling malaria—a disease that continues to claim more than 400,000 lives annually, especially those of African children. Using tethered flight data of wild mosquitoes, the distribution of flight parameters were evaluated as indicators of long-range migrants versus appetitive flyers, and the species specific seasonal differences and gonotrophic states compared between two flight activity modalities. Morphometrical differences were evaluated in the wings of mosquitoes exhibiting high flight activity (HFA) vs. low flight activity (LFA).

NOT Open Access | Long-lasting insecticidal nets and the quest for malaria eradication: a mathematical modeling approach

May 25, 2020 - 08:13 -- NOT Open Access
Enahoro I, Eikenberry S, Gumel AB, Huijben S, Paaijmans K
J Math Biol. 2020 May 23

Recent dramatic declines in global malaria burden and mortality can be largely attributed to the large-scale deployment of insecticidal-based measures, namely long-lasting insecticidal nets (LLINs) and indoor residual spraying. However, the sustainability of these gains, and the feasibility of global malaria eradication by 2040, may be affected by increasing insecticide resistance among the Anopheles malaria vector.


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