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plasmodium falciparum malaria

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

March 20, 2018 - 14:52 -- Open Access
Author(s): 
Frances Rocamora, Lei Zhu, Kek Yee Liong, Arjen Dondorp, Olivo Miotto, Sachel Mok, Zbynek Bozdech
Reference: 
PLoS Pathog 14(3): e1006930

Due to their remarkable parasitocidal activity, artemisinins represent the key components of first-line therapies against Plasmodium falciparum malaria.

Medical Treatment: 

Efficacy and Tolerability Outcomes of a Phase II, Randomized, Open-Label, Multicenter Study of a New Water-Dispersible Pediatric Formulation of Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in African Infa

December 27, 2017 - 12:49 -- Open Access
Author(s): 
Nicola Gargano, Lola Madrid, Quique Bassat, et al.
Reference: 
Antimicrob. Agents Chemother. January 2018 vol. 62 no. 1 e00596-17

Artemisinin combination therapies are considered the mainstay of malaria treatment, but pediatric-friendly formulations for the treatment of infants are scarce.

Efficacy of artemether–lumefantrine, artesunate–amodiaquine, and dihydroartemisinin–piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in Angola, 2015

February 9, 2017 - 14:47 -- Open Access
Author(s): 
Mateusz M. Plucinski, Pedro Rafael Dimbu, Filomeno Fortes, et al.
Reference: 
Malaria Journal 2017 16:62, 2 February 2017

No evidence was found to corroborate the specific allegation of artemisinin resistance in Lunda Sul.

Medical Condition: 

Evidence of non-Plasmodium falciparum malaria infection in Kédougou, Sénégal

January 7, 2017 - 14:46 -- Open Access
Author(s): 
Rachel F. Daniels, Awa Bineta Deme, Daouda Ndiaye, et al.
Reference: 
Malaria Journal 2017 16:9, 3 January 2017

These findings emphasize the limitations of the RDT used for malaria diagnosis and demonstrate that non-P. falciparum malaria infections occur in Sénégal.

Country: 
Medical Treatment: 

Adding a single low-dose of primaquine (0.25 mg/kg) to artemether-lumefantrine did not compromise treatment outcome of uncomplicated Plasmodium falciparum malaria in Tanzania: a randomized, single-blinded clinical trial

August 30, 2016 - 15:08 -- Open Access
Author(s): 
Richard Mwaiswelo, Billy Ngasala, Irina Jovel, Berit Aydin-Schmidt, Roland Gosling, Zul Premji, Bruno Mmbando, Anders Björkman and Andreas Mårtensson
Reference: 
Malaria Journal 2016 15:435, 26 August 2016

The new WHO recommendation of adding a single low-dose of PQ to AL did not compromise treatment outcome of uncomplicated P. falciparum malaria in Tanzania.

Is a reproduction number of one a threshold for Plasmodium falciparum malaria elimination?

August 1, 2016 - 10:17 -- Open Access
Author(s): 
Jamie T. Griffin
Reference: 
Malaria Journal 2016 15:389, 26 July 2016

This means that calculations of the reduction in R 0 that interventions can achieve (the effect size) have a useful and straightforward interpretation, whereas if the theoretical possibility of a bistable equilibrium were the real behaviour, then such effect size calculations would not have a clear interpretation.

Country: 

Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria

May 2, 2016 - 06:26 -- Open Access
Author(s): 
Thanaporn Wattanakul, Pramote Teerapong, Joel Tarning, et al.
Reference: 
Malaria Journal 2016 15:244, 27 April 2016

Paracetamol plasma concentrations after oral syrup and intramuscular administration in patients with acute falciparum malaria were described successfully by a two-compartment disposition model.

Up-regulated S100 calcium binding protein A8 in Plasmodium-infected patients correlates with CD4 + CD25 + Foxp3 regulatory T cell generation

October 12, 2015 - 16:45 -- Open Access
Author(s): 
Hyeong-Woo Lee, Tong-Soo Kim, Yoon-Joong Kang, Jung-Yeon Kim, Sangeun Lee, Won-Ja Lee, Youngjoo Sohn
Reference: 
Malaria Journal 2015, 14:385 (5 October 2015)

Treg cells suppress the activity of cytotoxic T cells, which kill malaria parasites; therefore, the up-regulation of S100A8 in malaria patients may contribute to pathogen immune escape or tolerance.

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