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plasmodium falciparum malaria

Efficacy and safety of dihydroartemisinin–piperaquine versus artemether–lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Ugandan children: a systematic review and meta-analysis of randomized control trials

April 7, 2021 - 12:49 -- Open Access
Author(s): 
Dawit Getachew Assefa, Eden Dagnachew Zeleke, Delayehu Bekele, Hanna Amanuel Tesfahunei, Emnet Getachew, Michele Joseph and Tsegahun Manyazewal
Reference: 
Malaria Journal 2021 20:174, 1 April 2021

The emergence of artemisinin resistance in Southeast Asia and Plasmodium falciparum kelch13 propeller gene mutations in sub-Saharan African pose the greatest threat to global efforts to control malaria. This is a critical concern in Uganda, where artemisinin-based combination therapy (ACT) is the first-line treatment for uncomplicated falciparum. The objective of this study was to compare the efficacy and safety of dihydroartemisinin–piperaquine (DHA–PQ) and artemether–lumefantrine (AL) for the treatment of uncomplicated falciparum malaria in Ugandan children.

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

March 20, 2018 - 14:52 -- Open Access
Author(s): 
Frances Rocamora, Lei Zhu, Kek Yee Liong, Arjen Dondorp, Olivo Miotto, Sachel Mok, Zbynek Bozdech
Reference: 
PLoS Pathog 14(3): e1006930

Due to their remarkable parasitocidal activity, artemisinins represent the key components of first-line therapies against Plasmodium falciparum malaria.

Medical Treatment: 

Efficacy and Tolerability Outcomes of a Phase II, Randomized, Open-Label, Multicenter Study of a New Water-Dispersible Pediatric Formulation of Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in African Infa

December 27, 2017 - 12:49 -- Open Access
Author(s): 
Nicola Gargano, Lola Madrid, Quique Bassat, et al.
Reference: 
Antimicrob. Agents Chemother. January 2018 vol. 62 no. 1 e00596-17

Artemisinin combination therapies are considered the mainstay of malaria treatment, but pediatric-friendly formulations for the treatment of infants are scarce.

Efficacy of artemether–lumefantrine, artesunate–amodiaquine, and dihydroartemisinin–piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in Angola, 2015

February 9, 2017 - 14:47 -- Open Access
Author(s): 
Mateusz M. Plucinski, Pedro Rafael Dimbu, Filomeno Fortes, et al.
Reference: 
Malaria Journal 2017 16:62, 2 February 2017

No evidence was found to corroborate the specific allegation of artemisinin resistance in Lunda Sul.

Medical Condition: 

Evidence of non-Plasmodium falciparum malaria infection in Kédougou, Sénégal

January 7, 2017 - 14:46 -- Open Access
Author(s): 
Rachel F. Daniels, Awa Bineta Deme, Daouda Ndiaye, et al.
Reference: 
Malaria Journal 2017 16:9, 3 January 2017

These findings emphasize the limitations of the RDT used for malaria diagnosis and demonstrate that non-P. falciparum malaria infections occur in Sénégal.

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Medical Treatment: 

Adding a single low-dose of primaquine (0.25 mg/kg) to artemether-lumefantrine did not compromise treatment outcome of uncomplicated Plasmodium falciparum malaria in Tanzania: a randomized, single-blinded clinical trial

August 30, 2016 - 15:08 -- Open Access
Author(s): 
Richard Mwaiswelo, Billy Ngasala, Irina Jovel, Berit Aydin-Schmidt, Roland Gosling, Zul Premji, Bruno Mmbando, Anders Björkman and Andreas Mårtensson
Reference: 
Malaria Journal 2016 15:435, 26 August 2016

The new WHO recommendation of adding a single low-dose of PQ to AL did not compromise treatment outcome of uncomplicated P. falciparum malaria in Tanzania.

Is a reproduction number of one a threshold for Plasmodium falciparum malaria elimination?

August 1, 2016 - 10:17 -- Open Access
Author(s): 
Jamie T. Griffin
Reference: 
Malaria Journal 2016 15:389, 26 July 2016

This means that calculations of the reduction in R 0 that interventions can achieve (the effect size) have a useful and straightforward interpretation, whereas if the theoretical possibility of a bistable equilibrium were the real behaviour, then such effect size calculations would not have a clear interpretation.

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Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria

May 2, 2016 - 06:26 -- Open Access
Author(s): 
Thanaporn Wattanakul, Pramote Teerapong, Joel Tarning, et al.
Reference: 
Malaria Journal 2016 15:244, 27 April 2016

Paracetamol plasma concentrations after oral syrup and intramuscular administration in patients with acute falciparum malaria were described successfully by a two-compartment disposition model.

Up-regulated S100 calcium binding protein A8 in Plasmodium-infected patients correlates with CD4 + CD25 + Foxp3 regulatory T cell generation

October 12, 2015 - 16:45 -- Open Access
Author(s): 
Hyeong-Woo Lee, Tong-Soo Kim, Yoon-Joong Kang, Jung-Yeon Kim, Sangeun Lee, Won-Ja Lee, Youngjoo Sohn
Reference: 
Malaria Journal 2015, 14:385 (5 October 2015)

Treg cells suppress the activity of cytotoxic T cells, which kill malaria parasites; therefore, the up-regulation of S100A8 in malaria patients may contribute to pathogen immune escape or tolerance.

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