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insecticide resistance

The making of a PNAS paper...here's our story

September 3, 2015 - 20:35 -- Bart G.J. Knols

Once a scientific paper is published online and you can download a pdf of it, this addictive and magnificent feeling gets on to you. This is the fruit of all the hard work: first to get the funding to undertake the research, then the hard work to actually perform all the research, then the hard work to write up the manuscript, then the submission, the reviews, the rebuttal, and eventually acceptance followed by proof reading and then publication. The route from thinking up research to publishing about it is long, tedious, and really hard work. But why don't we ever talk about this route? Why do we publish our papers but don't tell our peers more about how we got there? The fun parts, the sweat and tears, or even the fights? This week we published an article in the Proceedings of the National Academy of Sciences USA (PNAS; attached below). And here's the story you don't know when you read the paper...

Species diversity and insecticide resistance within the Anopheles hyrcanus group in Ubon Ratchathani Province, Thailand

October 21, 2020 - 08:25 -- Open Access
Author(s): 
Sumarnrote A, Overgaard HJ, Corbel V, Thanispong K, Chareonviriyaphap T, Manguin S
Reference: 
Parasit Vectors. 2020 Oct 17;13(1):525

Members of the Anopheles hyrcanus group have been incriminated as important malaria vectors. This study aims to identify the species and explore the insecticide susceptibility profile within the Anopheles hyrcanus group in Ubon Ratchathani Province, northeastern Thailand where increasing numbers of malaria cases were reported in 2014.

Evaluation of a game-based training course to build capacity for insecticide resistance management in vector control programmes

October 20, 2020 - 16:04 -- Open Access
Author(s): 
Dormann C, Duda K, Hamainza B, Yewhalaw D, Hemingway C, Coleman M, Coleman M, Thomsen E
Reference: 
PLoS One. 2020 Oct 15;15(10):e0240514

Across Africa, malaria control programmes are increasingly challenged with the emergence of insecticide resistance among malaria vector populations. Confronted with this challenge, vector control staff must understand insecticide resistance management, think comprehensively and react positively when confronted with new problems. However, information on the subject is often only available through written guidelines that are difficult to put into practice.

Not Open Access | Phenotypic Insecticide Resistance in Anopheles gambiae (Diptera: Culicidae): Specific Characterization of Underlying Resistance Mechanisms Still Matters

October 13, 2020 - 12:56 -- NOT Open Access
Author(s): 
Medjigbodo AA, Djogbenou LS, Koumba AA, Djossou L, Badolo A, Adoha CJ, Ketoh GK, Mavoungou JF
Reference: 
J Med Entomol. 2020 Oct 12:tjaa195

An effective control of malaria vectors requires an extensive knowledge of mechanisms underlying the resistance-phenotypes developed by these vectors against insecticides. We investigated Anopheles gambiae mosquitoes from Benin and Togo for their intensity of insecticide resistance and we discussed the involvement of genotyped mechanisms in the resistance-phenotypes observed.

Genome variation and population structure among 1142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii

October 7, 2020 - 14:38 -- Open Access
Author(s): 
Anopheles gambiae 1000 Genomes Consortium, Chris S Clarkson, Alistair Miles, Dominic P Kwiatkowski, et al.
Reference: 
Genome Res. 2020 Oct;30(10):1533-1546

Mosquito control remains a central pillar of efforts to reduce malaria burden in sub-Saharan Africa. However, insecticide resistance is entrenched in malaria vector populations, and countries with a high malaria burden face a daunting challenge to sustain malaria control with a limited set of surveillance and intervention tools.

Influence of GST- and P450-based metabolic resistance to pyrethroids on blood feeding in the major African malaria vector Anopheles funestus

September 22, 2020 - 10:33 -- Open Access
Author(s): 
Nouage L, Elanga-Ndille E, Binyang A, Tchouakui M, Atsatse T, Ndo C, Kekeunou S, Wondji CS
Reference: 
PLoS One. 2020 Sep 18;15(9):e0230984

Insecticide resistance genes are often associated with pleiotropic effects on various mosquito life-history traits. However, very little information is available on the impact of insecticide resistance on blood feeding process in mosquitoes. Here, using two recently detected DNA-based metabolic markers in the major malaria vector, An. funestus, we investigated how metabolic resistance genes could affect the blood meal intake.

Anopheles metabolic proteins in malaria transmission, prevention and control: a review

September 15, 2020 - 10:49 -- Open Access
Author(s): 
Adedeji EO, Ogunlana OO, Fatumo S, Beder T, Ajamma Y, Koenig R, Adebiyi E
Reference: 
Parasit Vectors. 2020 Sep 10;13(1):465.

The increasing resistance to currently available insecticides in the malaria vector, Anopheles mosquitoes, hampers their use as an effective vector control strategy for the prevention of malaria transmission. Therefore, there is need for new insecticides and/or alternative vector control strategies, the development of which relies on the identification of possible targets in Anopheles. Some known and promising targets for the prevention or control of malaria transmission exist among Anopheles metabolic proteins.

Insecticide resistance in indoor and outdoor-resting Anopheles gambiae in Northern Ghana

September 1, 2020 - 10:24 -- Open Access
Author(s): 
Majidah Hamid-Adiamoh, Alfred Amambua-Ngwa, Davis Nwakanma, Umberto D’Alessandro, Gordon A. Awandare and Yaw A. Afrane
Reference: 
Malaria Journal 2020 19:314, 31 August 2020

Selection pressure from continued exposure to insecticides drives development of insecticide resistance and changes in resting behaviour of malaria vectors. There is need to understand how resistance drives changes in resting behaviour within vector species. The association between insecticide resistance and resting behaviour of Anopheles gambiae sensu lato (s.l.) in Northern Ghana was examined.

Evaluating insecticide resistance across African districts to aid malaria control decisions

August 27, 2020 - 08:19 -- Open Access
Author(s): 
Moyes CL, Athinya DK, Seethaler T, Battle KE, Sinka M, Hadi MP, Hemingway J, Coleman M, Hancock PA
Reference: 
Proc Natl Acad Sci U S A. 2020 Aug 25:202006781

Malaria vector control may be compromised by resistance to insecticides in vector populations. Actions to mitigate against resistance rely on surveillance using standard susceptibility tests, but there are large gaps in the monitoring data across Africa. Using a published geostatistical ensemble model, we have generated maps that bridge these gaps and consider the likelihood that resistance exceeds recommended thresholds.

Investigating the molecular basis of multiple insecticide resistance in a major malaria vector Anopheles funestus (sensu stricto) from Akaka-Remo, Ogun State, Nigeria

August 19, 2020 - 16:09 -- Open Access
Author(s): 
Atoyebi SM, Tchigossou GM, Djouaka R, et al.
Reference: 
Parasit Vectors. 2020 Aug 18;13(1):423

Understanding the mechanisms used by Anopheles mosquitoes to survive insecticide exposure is key to manage existing insecticide resistance and develop more suitable insecticide-based malaria vector control interventions as well as other alternative integrated tools. To this regard, the molecular basis of permethrin, DDT and dieldrin resistance in Anopheles funestus (sensu stricto) at Akaka-Remo was investigated.

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