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insecticide resistance

The making of a PNAS's our story

September 3, 2015 - 20:35 -- Bart G.J. Knols

Once a scientific paper is published online and you can download a pdf of it, this addictive and magnificent feeling gets on to you. This is the fruit of all the hard work: first to get the funding to undertake the research, then the hard work to actually perform all the research, then the hard work to write up the manuscript, then the submission, the reviews, the rebuttal, and eventually acceptance followed by proof reading and then publication. The route from thinking up research to publishing about it is long, tedious, and really hard work. But why don't we ever talk about this route? Why do we publish our papers but don't tell our peers more about how we got there? The fun parts, the sweat and tears, or even the fights? This week we published an article in the Proceedings of the National Academy of Sciences USA (PNAS; attached below). And here's the story you don't know when you read the paper...

A survey of Anopheles species composition and insecticide resistance on the island of Bubaque, Bijagos Archipelago, Guinea-Bissau

January 20, 2020 - 15:52 -- Open Access
Thomas Ant, Erin Foley, David Mabey, et al.
Malaria Journal 2020 19:27, 15 January 2020

Bubaque is the most populous island of the Bijagos archipelago, a group of malaria-endemic islands situated off the coast of Guinea-Bissau, West Africa. Malaria vector control on Bubaque relies almost exclusively on the use of long-lasting insecticidal nets (LLINs). However, there is little information on local vector bionomics and insecticide resistance.

NOT Open Access | Multiple insecticide resistance in Anopheles culicifacies s.l. (Diptera: Culicidae) in east-central India

January 14, 2020 - 16:20 -- NOT Open Access
Sahu SS, Thankachy S, Dash S, Swaminathan S, Kasinathan G, Purushothaman J.
Pathogens and Global Health, 2020 Jan 5:1-7

Development of resistance among the vectors to different insecticides poses a potential threat to vector control programme. Regular monitoring of susceptibility status of vector species to commonly used insecticides is recommended for planning appropriate vector control measures. In this communication, we have determined the phenotypic resistance of Anopheles culicifacies s.l., the major malaria vector against commonly used various insecticides in ten highly malaria endemic districts of Odisha State in east-central India.

Functional genetic validation of key genes conferring insecticide resistance in the major African malaria vector, Anopheles gambiae

December 10, 2019 - 11:11 -- Open Access
Adolfi A, Poulton B, Anthousi A, Macilwee S, Ranson H, Lycett GJ
Proc Natl Acad Sci U S A. 2019 Dec 4. pii: 201914633

Resistance in Anopheles gambiae to members of all 4 major classes (pyrethroids, carbamates, organochlorines, and organophosphates) of public health insecticides limits effective control of malaria transmission in Africa. Increase in expression of detoxifying enzymes has been associated with insecticide resistance, but their direct functional validation in An. gambiae is still lacking.

Status of insecticide resistance in malaria vectors in Kwale County, Coastal Kenya

January 8, 2018 - 16:14 -- Open Access
Caroline W. Kiuru, Florence Awino Oyieke, Wolfgang Richard Mukabana, Joseph Mwangangi, Luna Kamau and Damaris Muhia-Matoke
Malaria Journal 2018 17:3, 5 January 2018

This study showed phenotypic resistance to pyrethroids and low frequency of L1014S kdr mutation in An. gambiae s.l.


RDL mutations predict multiple insecticide resistance in Anopheles sinensis in Guangxi, China

November 29, 2017 - 15:36 -- Open Access
Chan Yang, Zushi Huang, Mei Li, Xiangyang Feng and Xinghui Qiu
Malaria Journal 2017 16:482, 28 November 2017


The near fixation of the 296S mutation and the occurrence of the 327I and 345S mutations in addition to 296S, in all the nine tested An. sinensis populations in Guangxi, strongly indicate a risk of multiple insecticide resistance.

Medical Condition: 

Insecticide-treated nets provide protection against malaria to children in an area of insecticide resistance in Southern Benin

May 30, 2017 - 18:08 -- Open Access
John Bradley, Aurore Ogouyèmi-Hounto, Immo Kleinschmidt, et al.
Malaria Journal 2017 16:225, 26 May 2017

LLINs continue to offer individual protection against malaria infection in an area of high resistance. Insecticide resistance is not a reason to stop efforts to increase coverage of LLINs in Africa.

Medical Treatment: 

Not Open Access | Commentary: The threat (or not) of insecticide resistance for malaria control

August 19, 2016 - 18:43 -- NOT Open Access
Matthew B. Thomas and Andrew F. Read
PNAS August 9, 2016 vol. 113 no. 32 8900-8902

Malaria burdens have fallen dramatically this century, in large part because around a billion long-lasting insecticide-treated bed nets (LLINs) have been introduced into Africa (1, 2).


A significant association between deltamethrin resistance, Plasmodium falciparum infection and the Vgsc-1014S resistance mutation in Anopheles gambiae highlights the epidemiological importance of resistance markers

May 25, 2016 - 17:43 -- Open Access
Bilali Kabula, Patrick Tungu, Emily J. Rippon, Keith Steen, William Kisinza, Stephen Magesa, Franklin Mosha and Martin James Donnelly
Malaria Journal 2016 15:289, 23 May 2016

One marker, Vgsc-1014S, was associated with insecticide resistance and P. falciparum infection in wild-caught mixed aged populations of A. gambiae s.s. thereby showing how resistance may directly impact transmission.

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