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intermittent preventive treatment

Antibodies to full-length and the DBL5 domain of VAR2CSA in pregnant women after long-term implementation of intermittent preventive treatment in Etoudi, Cameroon

August 18, 2020 - 14:55 -- Open Access
Author(s): 
Djontu JC, Lloyd YM, Megnekou R, Seumko'o RMN, Salanti A, Taylor DW, Leke RGF
Reference: 
PLoS ONE 15(8): e0237671

In high malaria transmission settings, the use of sulfadoxine-pyrimethamine-based intermittent preventive treatment during pregnancy (IPTp-SP) has resulted in decreased antibody (Ab) levels to VAR2CSA. However, information of Ab levels in areas of low or intermediate malaria transmission after long-term implementation of IPTp-SP is still lacking. The present study sought to evaluate antibody prevalence and levels in women at delivery in Etoudi, a peri-urban area in the capital of Yaoundé, Cameroon, that is a relatively low-malaria transmission area.

Impact of intermittent preventive treatment of malaria in pregnancy with dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine on the incidence of malaria in infancy: a randomized controlled trial

August 11, 2020 - 07:39 -- Open Access
Author(s): 
Kakuru A, Jagannathan P, Dorsey G, et al.
Reference: 
BMC Med. 2020 Aug 10;18(1):207

Intermittent preventive treatment of malaria during pregnancy (IPTp) with dihydroartemisinin-piperaquine (DP) significantly reduces the burden of malaria during pregnancy compared to sulfadoxine-pyrimethamine (SP), the current standard of care, but its impact on the incidence of malaria during infancy is unknown.

A cluster randomized trial of delivery of intermittent preventive treatment of malaria in pregnancy at the community level in Burkina Faso

August 10, 2020 - 14:54 -- Open Access
Author(s): 
Julie R. Gutman, Daniel K. Stephens, Justin Tiendrebeogo, Ousmane Badolo, Mathurin Dodo, Danielle Burke, John Williamson, Kristen Vibbert, Susan J. Youll, Yacouba Savadogo and William R. Brieger
Reference: 
Malaria Journal 2020 19:282, 5 August 2020

Malaria in pregnancy is responsible for 8–14% of low birth weight and 20% of stillbirths in sub-Saharan Africa. To prevent these adverse consequences, the World Health Organization recommends intermittent preventive treatment of pregnant women (IPTp) with sulfadoxine–pyrimethamine be administered at each ANC visit starting as early as possible in the second trimester. Global IPTp coverage in targeted countries remains unacceptably low. Community delivery of IPTp was explored as a means to improve coverage.

Coverage of intermittent preventive treatment of malaria in pregnancy (IPTp) influences delivery outcomes among women with obstetric referrals at the district level in Ghana

June 26, 2020 - 11:06 -- Open Access
Author(s): 
Mary Amoakoh-Coleman, Daniel K. Arhinful, Kerstin Klipstein-Grobusch, Evelyn K. Ansah and Kwadwo A. Koram
Reference: 
Malaria Journal 2020 19:222, 24 June 2020

The aim of the study was to determine the coverage of intermittent preventive treatment of malaria in pregnancy (IPTp) and its relationship with delivery outcomes among obstetric referral cases at the district level of healthcare.

Uptake of intermittent preventive treatment for malaria during pregnancy with Sulphadoxine-Pyrimethamine in Malawi after adoption of updated World Health Organization policy: an analysis of demographic and health survey 2015-2016

March 19, 2020 - 08:50 -- Open Access
Author(s): 
Azizi SC
Reference: 
BMC Public Health. 2020 Mar 16; 20(1):335

Malawi adopted the 2012 updated Word Health Organization (WHO) Intermittent preventive treatment of malaria during pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) policy in 2013. This study aimed to estimate the proportion of and identify factors associated with the uptake of at least three doses of IPTp with SP among pregnant women in Malawi after the adoption and operationalisation of updated WHO IPTp-SP policy.

Effectiveness of Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Malaria and Adverse Birth Outcomes in Pregnant Women

March 18, 2020 - 14:43 -- Open Access
Author(s): 
Mlugu EM, Minzi O, Asghar M, Färnert A, Kamuhabwa AAR, Aklillu E
Reference: 
Pathogens. 2020 Mar 11;9(3). pii: E207

Effectiveness of intermittent preventive treatment in pregnancy with sulfadoxine–pyrimethamine (IPTp-SP) for prevention of malaria and adverse birth outcomes can be compromised by parasites-resistance to sulfadoxine–pyrimethamine. This study prospectively evaluated the effectiveness of IPTp-SP in Southeast Tanzania. From January 2017 to May 2019, HIV-negative and malaria-negative (mRDT) pregnant women attending their first antenatal-care visit in the second or third trimester (n = 500) were enrolled to receive monthly IPTp-SP and followed the protocol till delivery.

Coverage and effectiveness of intermittent preventive treatment in pregnancy with sulfadoxine–pyrimethamine (IPTp-SP) on adverse pregnancy outcomes in the Mount Cameroon area, South West Cameroon

March 9, 2020 - 13:51 -- Open Access
Author(s): 
Judith K. Anchang-Kimbi, Laken N. Kalaji, Harry F. Mbacham, Godlove B. Wepnje, Tobias O. Apinjoh, Irene U. Ngole Sumbele, Jodie Dionne-Odom, Alan T. N. Tita and Eric A. Achidi
Reference: 
Malaria Journal 2020 19:100, 2 March 2020

Growing concerns about the waning efficacy of IPTp-SP warrants continuous monitoring and evaluation. This study determined coverage of IPTp-SP and compared the effectiveness of the 3-dose to 2-dose regimen on placental malaria (PM) infection and low birth weight (LBW) in the Mount Cameroon area.

Uptake of intermittent preventive treatment for malaria in pregnancy among women in selected communities of Ebonyi State, Nigeria

December 10, 2019 - 20:11 -- Open Access
Author(s): 
Akpa CO, Akinyemi JO, Umeokonkwo CD, Bamgboye EA, Dahiru T, Adebowale AS, Ajayi IO
Reference: 
BMC Pregnancy Childbirth. 2019 Dec 2;19(1):457

Malaria in pregnancy has adverse effects on maternal and child health. Intermittent preventive treatment (IPTp) with three doses of Sulfadoxine/Pyrimethamine is an effective preventive measure for malaria in pregnancy. However, 24.0% of women use this prophylactic regimen in Ebonyi State. Previous studies have focused on the level of uptake with less attention given to factors influencing uptake. Therefore, we examined the predictors of IPTp uptake in the last pregnancy among women in Ebonyi State, Nigeria.

Factors influencing adherence to the new intermittent preventive treatment of malaria in pregnancy policy in Keta District of the Volta region, Ghana

December 2, 2019 - 18:02 -- Open Access
Author(s): 
Vandy AO, Peprah NY, Jerela JY, Titiati P, Manu A, Akamah J, Maya ET, Torpey K
Reference: 
BMC Pregnancy Childbirth. 2019 Nov 20;19(1):424

About 25% of pregnant women in malaria-endemic areas are infected with malaria and this accounts for about 15% of maternal deaths globally. Intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) is one of the main strategies for prevention of malaria in pregnancy. A new recommendation was made by the World Health Organization (WHO) that at least three doses of IPTp-SP should be administered before delivery. This study sought to determine the factors influencing adherence to the new IPTp-SP policy in Keta District, Volta region, Ghana.

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Determinants of uptake of intermittent preventive treatment during pregnancy: a review

November 30, 2019 - 12:21 -- Open Access
Author(s): 
Roman E, Andrejko K, Wolf K, Henry M, Youll S, Florey L, Ferenchick E, Gutman JR
Reference: 
Malar J. 2019 Nov 21;18(1):372. doi: 10.1186/s12936-019-3004-7

Malaria in pregnancy (MiP) contributes to devastating maternal and neonatal outcomes. Coverage of intermittent preventive treatment during pregnancy (IPTp) remains alarmingly low.

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