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malaria; Sanaria; consortium

The International PfSPZ Consortium meets to review data and map out the clinical development pathway for the Plasmodium falciparum sporozoite-based vaccines

July 2, 2015 - 17:38 -- Ingeborg van Schayk

Candidate vaccines based on injectable Plasmodium falciparum (Pf) sporozoites (SPZ), are being developed and tested. These include PfSPZ Vaccine, in which the PfSPZ are attenuated by irradiation; PfSPZ-CVac, in which fully infectious PfSPZ, PfSPZ Challenge, are attenuated in vivo by an anti-malarial drug, to allow only liver stage parasites to grow, and PfSPZ-GA1, in which the PfSPZ are attenuated by gene deletions.

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