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Anopheles gambiae

Mapping trends in insecticide resistance phenotypes in African malaria vectors

June 29, 2020 - 16:10 -- Open Access
Hancock PA, Hendriks CJM, Tangena JA, Gibson H, Hemingway J, Coleman M, Gething PW, Cameron E, Bhatt S, Moyes CL
PLoS Biol. 2020 Jun 25; 18(6):e3000633

Mitigating the threat of insecticide resistance in African malaria vector populations requires comprehensive information about where resistance occurs, to what degree, and how this has changed over time. Estimating these trends is complicated by the sparse, heterogeneous distribution of observations of resistance phenotypes in field populations.

NOT Open Access | Isolation and transcriptomic analysis of Anopheles gambiae oenocytes enables the delineation of hydrocarbon biosynthesis

June 17, 2020 - 12:51 -- NOT Open Access
Grigoraki L, Grau-Bové X, Carrington Yates H, Lycett GJ, Ranson H
Elife. 2020 Jun 15;9:e58019

The surface of insects is coated in cuticular hydrocarbons (CHCs); variations in the composition of this layer affect a range of traits including adaptation to arid environments and defence against pathogens and toxins. In the African malaria vector, Anopheles gambiae quantitative and qualitative variance in CHC composition have been associated with speciation, ecological habitat and insecticide resistance.

Adult Mosquitoes Infected with Bacteria Early in Life Have Stronger Antimicrobial Responses and More Hemocytes after Reinfection Later in Life

June 2, 2020 - 13:55 -- Open Access
Powers JC, Turangan R, Joosse BA, Hillyer JF
Insects. 2020 May 28; 11(6):E331

The immunological strategies employed by insects to overcome infection vary with the type of infection and may change with experience. We investigated how a bacterial infection in the hemocoel of the African malaria mosquito, Anopheles gambiae, prepares the immune system to face a subsequent bacterial infection. For this, adult female mosquitoes were separated into three groups-unmanipulated, injured, or infected with Escherichia coli-and five days later all the mosquitoes were infected with a different strain of E. coli.

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae

May 13, 2020 - 14:39 -- Open Access
Simoni A, Hammond AM, Crisanti A, et al.
Nat Biotechnol. 2020 May 11

Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control methods that bias the sex ratio of insect offspring have long been sought. Genetic elements such as sex-chromosome drives can distort sex ratios to produce unisex populations that eventually collapse, but the underlying molecular mechanisms are unknown.

Intensity of pyrethroid resistance in Anopheles gambiae before and after a mass distribution of insecticide-treated nets in Kinshasa and in 11 provinces of the Democratic Republic of Congo

May 4, 2020 - 15:17 -- Open Access
Francis Wat’senga, Fiacre Agossa, Seth R. Irish, et al.
Malaria Journal 2020 19:169, 30 April 2020

Between 2011 and 2018, an estimated 134.8 million pyrethroid-treated long-lasting insecticidal nets (LLINs) were distributed nationwide in the Democratic Republic of Congo (DRC) for malaria control. Pyrethroid resistance has developed in DRC in recent years, but the intensity of resistance and impact on LLIN efficacy was not known. Therefore, the intensity of resistance of Anopheles gambiae sensu lato (s.l.) to permethrin and deltamethrin was monitored before and after a mass distribution of LLINs in Kinshasa in December 2016, and in 6 other sites across the country in 2017 and 11 sites in 2018.

Broad spectrum immunomodulatory effects of Anopheles gambiae microRNAs and their use for transgenic suppression of Plasmodium

April 27, 2020 - 13:18 -- Open Access
Dong S, Fu X, Dong Y, Simões ML, Zhu J, Dimopoulos G
PLoS Pathog 16(4): e1008453

Malaria, caused by the protozoan parasite Plasmodium and transmitted by Anopheles mosquitoes, represents a major threat to human health. Plasmodium’s infection cycle in the Anopheles vector is critical for transmission of the parasite between humans. The midgut-stage bottleneck of infection is largely imposed by the mosquito’s innate immune system. microRNAs (miRNAs, small noncoding RNAs that bind to target RNAs to regulate gene expression) are also involved in regulating immunity and the anti-Plasmodium defense in mosquitoes.

20-Hydroxyecdysone Primes Innate Immune Responses That Limit Bacterial and Malarial Parasite Survival in Anopheles gambiae

April 20, 2020 - 08:59 -- Open Access
Reynolds RA, Kwon H, Smith RC
mSphere. 2020 Apr 15;5(2). pii: e00983-19

Blood feeding is an integral behavior of mosquitoes to acquire nutritional resources needed for reproduction. This requirement also enables mosquitoes to serve as efficient vectors to acquire and potentially transmit a multitude of mosquito-borne diseases, most notably malaria. Recent studies suggest that mosquito immunity is stimulated following a blood meal, independent of infection status.

Quantifying late-stage host-seeking behaviour of Anopheles gambiae at the insecticidal net interface using a baited-box bioassay

April 10, 2020 - 17:13 -- Open Access
Angela Hughes, Geraldine M. Foster, Amy Guy, Agnes Matope, Mayumi Abe, David Towers and Philip J. McCall
Malaria Journal 2020 19:140, 7 April 2020

Insecticide-treated nets (ITNs) are losing efficacy against pyrethroid-resistant malaria vector populations throughout Africa. Safeguarding bed net efficacy, vital for effective malaria control, requires greater knowledge of mosquito–ITN interactions and how this impacts on the mosquito.

Structural Variation of the X Chromosome Heterochromatin in the Anopheles gambiae Complex

March 25, 2020 - 14:49 -- Open Access
Sharma A, Kinney NA, Timoshevskiy VA, Sharakhova MV, Sharakhov IV
Genes (Basel). 2020 Mar 19;11(3). pii: E327

Heterochromatin is identified as a potential factor driving diversification of species. To understand the magnitude of heterochromatin variation within the Anopheles gambiae complex of malaria mosquitoes, we analyzed metaphase chromosomes in An. arabiensis, An. coluzzii, An. gambiae, An. merus, and An. quadriannulatus.

Pragmatic selection of larval mosquito diets for insectary rearing of Anopheles gambiae and Aedes aegypti

March 17, 2020 - 16:34 -- Open Access
Benedict MQ, Hunt CM, Vella MG, Gonzalez KM, Dotson EM, Collins CM
PLoS One. 2020 Mar 11;15(3):e0221838

Larval mosquitoes are aquatic omnivorous scavengers which scrape food from submerged surfaces and collect suspended food particles with their mouth brushes. The composition of diets that have been used in insectaries varies widely though necessarily provides sufficient nutrition to allow colonies to be maintained.


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