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drug-resistance

NOT Open Access | Safety, Pharmacokinetics, and Causal Prophylactic Efficacy of KAF156 in a Plasmodium falciparum Human Infection Study

October 13, 2021 - 12:43 -- NOT Open Access
Author(s): 
Kublin JG, Murphy SC, Prince WT, et al.
Reference: 
Clin Infect Dis. 2021 Oct 5;73(7):e2407-e2414

KAF156 is a novel antimalarial drug that is active against both liver- and blood-stage Plasmodium parasites, including drug-resistant strains. Here, we investigated the causal prophylactic efficacy of KAF156 in a controlled human malaria infection (CHMI) model.

NOT Open Access | Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents

August 19, 2020 - 09:23 -- NOT Open Access
Author(s): 
Liu H, Futamura Y, Wu H, Ishiyama A, Zhang T, Shi T, Zheng Q, Iwatsuki M, Ōmura S, Zou H, Osada H
Reference: 
Med Chem. 2020 Aug 17

Malaria is one of the most devastating parasitic diseases, yet the discovery of antimalarial agents remains profoundly challenging. Very few new antimalarials have been developed in the past 50 years, while the emergence of drug-resistance continues to appear.

Not Open Access | Recent advances in novel heterocyclic scaffolds for the treatment of drug-resistant malaria

March 18, 2015 - 12:37 -- NOT Open Access
Author(s): 
Sahil Kumar, Rajesh K. Singh, Babita Patial, Sachin Goyal, T. R. Bhardwaj
Reference: 
Journal of Enzyme Inhibition and Medicinal Chemistry, March 16, 2015

This review presents recent modifications of 4-aminoquinoline and 8-aminoquinolone rings as leads to novel active molecules which are under clinical trials. The review also encompasses the other heterocyclic compounds emerged as potential antimalarial agents with promising results such as acridinediones and acridinone analogues, pyridines and quinolones as antimalarials.

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