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pregnant women

Impact of placental malaria on maternal, placental and fetal cord responses and its role in pregnancy outcomes in women from Blue Nile State, Sudan

January 13, 2021 - 10:08 -- Open Access
Author(s): 
Samia Omer, Clara Franco-Jarava, Ali Noureldien, Mona Omer, Mutasim Abdelrahim, Israel Molina and Ishag Adam
Reference: 
Malaria Journal 2021 20:35, 9 January 2021

The sequestration of Plasmodium falciparum infected cells in the placenta results in placental malaria (PM). It activates the mother's immune cells and induces secretion of inflammatory cytokines, which might influence pregnancy outcomes. This study aims to investigate the cytokines (levels IL-4, IL-6, IL-10, IL-17A, and INF γ) in maternal peripheral, placental, and umbilical cord blood in response to PM and the extent to which this may influence maternal haemoglobin levels and birth weight.

VAR2CSA Antibodies in Non-Pregnant Populations

January 7, 2021 - 09:08 -- Open Access
Author(s): 
Gnidehou S, Yanow SK
Reference: 
Trends Parasitol. 2021 Jan;37(1):65-76

The Plasmodium falciparum protein VAR2CSA is a critical mediator of placental malaria, and VAR2CSA antibodies (IgGs) are important to protect pregnant women. Although infrequently detected outside pregnancy, VAR2CSA IgGs were reported in men and children from Colombia and Brazil and in select African populations.

Determinants of uptake of malaria preventive interventions among pregnant women in eastern Uganda

January 6, 2021 - 11:43 -- Open Access
Author(s): 
Solomon Tsebeni Wafula, Hilbert Mendoza, Aisha Nalugya, David Musoke and Peter Waiswa
Reference: 
Malaria Journal 2021 20:5, 3 January 2021

Consistent use of insecticide-treated nets (ITNs) and intermittent preventive treatment in pregnancy (IPTp) have been recommended as cost-effective interventions for malaria prevention during pregnancy in endemic areas. However, the coverage and utilization of these interventions during pregnancy in sub-Saharan Africa is still suboptimal. This study aimed to determine the uptake of IPTp and ITNs and associated factors among women during their recent pregnancy in Eastern Uganda.

Piperaquine pharmacokinetics during intermittent preventive treatment for malaria in pregnancy

December 29, 2020 - 15:37 -- Open Access
Author(s): 
Chotsiri P, Gutman J, Tarning J, et al.
Reference: 
Antimicrob Agents Chemother. 2020 Dec 23:AAC.01150-20

Dihydroartemisinin-piperaquine (DP) is a long-acting artemisinin combination treatment that provides effective chemoprevention and has been proposed as an alternative antimalarial drug for intermittent-preventive therapy in pregnancy (IPTp). Several pharmacokinetic studies have shown that dose adjustment may not be needed for the treatment of malaria in pregnancy with DP. However, there are limited data on the optimal dosing for IPTp.

Trust, community health workers and delivery of intermittent preventive treatment of malaria in pregnancy: a comparative qualitative analysis of four sub-Saharan countries

December 9, 2020 - 07:35 -- Open Access
Author(s): 
Enguita-Fernàndez C, Alonso Y, Lusengi W, Mayembe A, Manun'Ebo MF, Ranaivontiavina S, Rasoamananjaranahary AM, Mucavele E, Macete E, Nwankwo O, Meremikwu M, Roman E, Pagnoni F, Menéndez C, Munguambe K
Reference: 
Glob Public Health. 2020 Dec 8:1-15

This qualitative study is part of a project aiming to evaluate a community-based approach to the delivery of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) through community health workers (CHWs) in four sub-Saharan African countries: the Democratic Republic of Congo (DRC), Madagascar, Mozambique and Nigeria.

Averting expenditure on malaria: effects on labour productivity of maize farmers in Bunkpurugu-Nakpanduri District of Ghana

December 3, 2020 - 13:03 -- Open Access
Author(s): 
Franklin Nantui Mabe and Thomas Dafurika
Reference: 
Malaria Journal 2020 19:448, 3 December 2020

Malaria has been one of the commonest diseases during farming season, which affects farmers’ health resulting in a reduction in the number of days spent on the farm. As a result, farmers are regularly trying to avert malaria infection through preventive measures. Motivated by this argument, this study sought to determine the effects of malaria averting expenditure on labour productivity of maize farmers in Bunkpurugu-Nakpanduri District in the Northern Region of Ghana.

Back to school for malaria prevention: a new tool in the era of malaria elimination

December 2, 2020 - 09:47 -- Open Access
Author(s): 
van Eijk AM, Hill J
Reference: 
Lancet Glob Health. 2020 Dec;8(12):e1447-e1448

Children and pregnant women are at increased risk of malaria. Among children, research to date has focused on preschool children (aged <5 years) because this age group has the highest malaria death and illness rates of malaria illness and deaths. With changing malaria endemicity, however, vulnerability patterns among children of different age groups might change.

Evaluation of a single screen and treat strategy to detect asymptomatic malaria among pregnant women from selected health facilities in Lindi region, Tanzania

December 2, 2020 - 09:45 -- Open Access
Author(s): 
Chonge Kitojo, Frank Chacky, Emmanuel S. Kigadye, Joseph P. Mugasa, Abdallah Lusasi, Ally Mohamed, Patrick Walker, Erik J. Reaves, Julie R. Gutman & Deus S. Ishengoma
Reference: 
Malar J 19, 438 (2020)

In areas of high transmission, malaria in pregnancy (MiP) primarily causes asymptomatic infections; these infections nonetheless increase the risk of adverse maternal and fetal outcomes. In 2014, Tanzania initiated a single screening and treatment (SST) strategy for all pregnant women at their first antenatal care (ANC) visit using malaria rapid diagnostic tests (RDT) for surveillance purposes. However, there is paucity of data on the effectiveness of SST in the prevention of MiP. The objective of this study was to estimate the number of asymptomatic infections among pregnant women detected by SST, which would have been missed in the absence of the policy.

Evaluation of a single screen and treat strategy to detect asymptomatic malaria among pregnant women from selected health facilities in Lindi region, Tanzania

December 2, 2020 - 07:46 -- Open Access
Author(s): 
Chonge Kitojo, Frank Chacky, Emmanuel S. Kigadye, Joseph P. Mugasa, Abdallah Lusasi, Ally Mohamed, Patrick Walker, Erik J. Reaves, Julie R. Gutman and Deus S. Ishengoma
Reference: 
Malaria Journal 2020 19:438, 30 November 2020

In areas of high transmission, malaria in pregnancy (MiP) primarily causes asymptomatic infections; these infections nonetheless increase the risk of adverse maternal and fetal outcomes. In 2014, Tanzania initiated a single screening and treatment (SST) strategy for all pregnant women at their first antenatal care (ANC) visit using malaria rapid diagnostic tests (RDT) for surveillance purposes. However, there is paucity of data on the effectiveness of SST in the prevention of MiP. The objective of this study was to estimate the number of asymptomatic infections among pregnant women detected by SST, which would have been missed in the absence of the policy.

Intermittent screening and treatment with dihydroartemisinin-piperaquine for the prevention of malaria in pregnancy: implementation feasibility in a routine healthcare system setting in western Keny

November 28, 2020 - 16:20 -- Open Access
Author(s): 
Jenny Hill, Peter Ouma, Seth Oluoch, Jane Bruce, Simon Kariuki, Meghna Desai & Jayne Webster
Reference: 
Malaria Journal 2020 19:433, 25 November 2020

Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended for preventing malaria in pregnancy in areas of moderate-to-high transmission in sub-Saharan Africa. However, due to increasing parasite resistance to SP, research on alternative strategies is a priority. The study assessed the implementation feasibility of intermittent screening and treatment (ISTp) in the second and third trimester at antenatal care (ANC) with malaria rapid diagnostic tests (RDTs) and treatment of positive cases with dihydroartemisinin-piperaquine (DP) compared to IPTp-SP in western Kenya.

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