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pregnant women

Evaluation of highly sensitive diagnostic tools for the detection of P. falciparum in pregnant women attending antenatal care visits in Colombia

August 4, 2020 - 15:37 -- Open Access
Author(s): 
Vásquez AM, Vélez G, Medina A, Serra-Casas E, Campillo A, Gonzalez IJ, Murphy SC, Seilie AM, Ding XC, Tobón Castaño A
Reference: 
BMC Pregnancy Childbirth. 2020 Jul 31;20(1):440

In low transmission settings early diagnosis is the main strategy to reduce adverse outcomes of malaria in pregnancy; however, microscopy and rapid diagnostic tests (RDTs) are inadequate for detecting low-density infections. We studied the performance of the highly sensitive-RDT (hsRDT) and the loop mediated isothermal DNA amplification (LAMP) for the detection of P. falciparum in pregnant women.

Quantifying and preventing Plasmodium vivax recurrences in primaquine-untreated pregnant women: An observational and modeling study in Brazil

August 4, 2020 - 15:35 -- Open Access
Author(s): 
Corder RM, de Lima ACP, Khoury DS, Docken SS, Davenport MP, Ferreira MU
Reference: 
PLoS Negl Trop Dis 14(7): e0008526

Each year, 4.3 million pregnant women are exposed to malaria risk in Latin America and the Caribbean. Plasmodium vivax causes 76% of the regional malaria burden and appears to be less affected than P. falciparum by current elimination efforts. This is in part due to the parasite's ability to stay dormant in the liver and originate relapses within months after a single mosquito inoculation. Primaquine (PQ) is routinely combined with chloroquine (CQ) or other schizontocidal drugs to supress P. vivax relapses and reduce the risk of late blood-stage recrudescences of parasites with low-grade CQ resistance.

Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis

August 3, 2020 - 16:31 -- Open Access
Author(s): 
Saito M, Mansoor R, Kennon K, Guérin PJ, et al.
Reference: 
Lancet Infect Dis. 2020 Aug;20(8):943-952

Malaria in pregnancy affects both the mother and the fetus. However, evidence supporting treatment guidelines for uncomplicated (including asymptomatic) falciparum malaria in pregnant women is scarce and assessed in varied ways. We did a systematic literature review and individual patient data (IPD) meta-analysis to compare the efficacy and tolerability of different artemisinin-based or quinine-based treatments for malaria in pregnant women.

NOT Open Access | Updated pharmacokinetic considerations for the use of antimalarial drugs in pregnant women

August 3, 2020 - 15:37 -- NOT Open Access
Author(s): 
Moore BR, Davis TME
Reference: 
Expert Opin Drug Metab Toxicol. 2020 Jul 30

The association between pregnancy and altered drug pharmacokinetic (PK) properties is acknowledged, as is its impact on drug plasma concentrations and thus therapeutic efficacy. However, there have been few robust PK studies of antimalarial use in pregnancy. Given that inadequate dosing for prevention or treatment of malaria in pregnancy can result in negative maternal/infant outcomes, along with the potential to select for parasite drug resistance, it is imperative that reliable pregnancy-specific dosing recommendations are established.

Innate immune responses to malaria-infected erythrocytes in pregnant women: Effects of gravidity, malaria infection, and geographic location

July 30, 2020 - 13:35 -- Open Access
Author(s): 
Jabbarzare M, Njie M, Jaworowski A, Umbers AJ, Ome-Kaius M, Hasang W, Randall LM, Kalionis B, Rogerson SJ
Reference: 
PLoS ONE 15(7): e0236375

Malaria in pregnancy causes maternal, fetal and neonatal morbidity and mortality, and maternal innate immune responses are implicated in pathogenesis of these complications. The effects of malaria exposure and obstetric and demographic factors on the early maternal immune response are poorly understood.

Occurrence of septuple and elevated Pfdhfr-Pfdhps quintuple mutations in a general population threatens the use of sulfadoxine-pyrimethamine for malaria prevention during pregnancy in eastern-coast of Tanzania

July 26, 2020 - 13:34 -- Open Access
Author(s): 
Bwire GM, Mikomangwa WP, Kilonzi M
Reference: 
BMC Infect Dis. 2020 Jul 22;20(1):530

Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthetase (Pfdhps) mutations compromise the effectiveness of sulfadoxine-pyrimethamine (SP) for treatment of uncomplicated malaria, and are likely to impair the efficiency of intermittent preventive treatment during pregnancy (IPTp). This study was conducted to determine the level of Pfdhfr-Pfdhps mutations, a decade since SP was limited for IPTp use in pregnant women in Tanzania.

Associations of malaria, HIV, and coinfection, with anemia in pregnancy in sub-Saharan Africa: a population-based cross-sectional study

June 30, 2020 - 14:50 -- Open Access
Author(s): 
Ssentongo P, Ba DM, Ssentongo AE, Ericson JE, Wang M, Liao D, Chinchilli VM
Reference: 
BMC Pregnancy Childbirth. 2020 Jun 29; 20(1):379

Malaria and HIV are common infections in Africa and cause substantial morbidity and mortality in pregnant women. We aimed to assess the association of malaria with anemia in pregnant women and to explore the joint effects of malaria and HIV infection on anemia in pregnant women.

Effectiveness of a health education intervention on the use of long-lasting insecticidal nets for the prevention of malaria in pregnant women of Pakistan: a quasi-experimental study

June 30, 2020 - 14:26 -- Open Access
Author(s): 
Ramesh Kumar, Midhat Farzeen, Assad Hafeez, Baseer Khan Achakzai, Muskan Vankwani, Manohar Lal, Rabia Iqbal and Ratana Somrongthong
Reference: 
Malaria Journal 2020 19:232, 29 June 2020

About one quarter of pregnant women in the population of Pakistan are using long-lasting insecticide-treated bed nets (LLINs) for prevention of malaria. Past research reported that adequate information and education would act as mediator to change behaviour among patients for prevention of malaria infection. The effective use of LLINs would contribute to reduction of disease burden caused by malaria. The aim of this study was to determine the effectiveness of health education on the adoption of LLINs among pregnant women living in Tharparkar, a remote district in Sindh Province, Pakistan.

NOT Open Access | Circulating cytokines associated with poor pregnancy outcomes in Beninese exposed to infection with Plasmodium falciparum

June 9, 2020 - 16:20 -- NOT Open Access
Author(s): 
Hountohotegbe T, Gbedande K, Agbota G, Ibitokou S, Massougbodji A, Deloron P, Fievet N, Luty AJF
Reference: 
Infect Immun. 2020 Jun 8:IAI.00042-20

Malaria during pregnancy is a major cause of maternal morbidity as well as fetal and neonatal mortality. Previous studies including our own suggested that placental and peripheral cytokines and chemokines levels measured at delivery can be used as biomarkers for pregnancy outcomes. However, the timing of malaria infection during pregnancy matters and these studies lack in addressing the effect of different cytokines in peripheral blood plasma samples taken at early- mid-pregnancy and at delivery. Here we aimed to investigate whether peripheral plasma cytokine levels were associated with pregnancy outcomes in a cohort of 400 Beninese pregnant women.

COVID-19 and the impact on malaria

June 2, 2020 - 09:36 -- Open Access
Author(s): 
Chiodini J
Reference: 
Travel Med Infect Dis. 2020 May 29:101758

As COVID -19 continues to dominate the health and political agendas in so many countries around the world, so does its devastating impact on other diseases become apparent. Malaria is just one of these.

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