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pregnant women

Malaria and curable sexually transmitted and reproductive tract coinfection among pregnant women in rural Burkina Faso

November 10, 2021 - 20:57 -- Open Access
Lingani M, Zango, Dramaix M, et al.
Trop Med Health. 2021 Nov 4;49(1):90

Malaria and sexually transmitted/reproductive tract infections (STI/RTI) are leading and preventable causes of low birthweight in sub-Saharan Africa. Reducing their impact on pregnancy outcomes requires efficient interventions that can be easily integrated into the antenatal care package. The paucity of data on malaria and STI/RTI coinfection, however, limits efforts to control these infections. This study aimed to determine the prevalence and associated factors of malaria and STI/RTI coinfection among pregnant women in rural Burkina Faso.

The provider’s checklist to improve pregnant women coverage by intermittent preventive malaria treatment in Mali: a pilot implementation study

October 29, 2021 - 14:09 -- Open Access
Issa Doumbia, Fomba Seydou, Koné Diakalia and Issam Bennis
Malaria Journal 2021 20:402, 16 October 2021

Intermittent preventive treatment of malaria in pregnancy (IPTp) is a comprehensive treatment protocol of anti-malarial drugs administered to pregnant women to prevent malaria, started at the fourth pregnancy month, with at least three doses of sulfadoxine–pyrimethamine (SP), taken as directly observed treatment (DOT) every 30 days at intervals until childbirth, in combination with other preventive measures. This paper introduces feasibility and adoption concepts as implementation research outcomes (IRO), allowing after a defined intervention, to assess the coverage improvement by IPTp for women attending a reference district hospital in Mali. Specifically, the purpose is to evaluate the feasibility of a reminder tool (provider checklist) to enhance pregnant women’s adoption of information about IPTp-SP uptake as immediate and sustained women practices.

Assessing health system factors affecting access and delivery of IPTp-SP and ITN to pregnant women attending ANC clinics in Ghana

October 16, 2021 - 20:02 -- Open Access
De-Gaulle VF, Magnussen P, Kamgno J, Mbacham W, Orish VN, Tagbor H
BMC Health Serv Res. 2021 Oct 6;21(1):1056

Malaria interventions including use of Sulfadoxine-Pyrimethamine as Intermittent Preventive Treatment (IPTp-SP) and distribution of Insecticide Treated Nets (ITNs) have been implemented through ante-natal clinic (ANC) services in Ghana. Yet, the high ANC attendance is not commensurate with the uptake of these interventions, with missed opportunities to deliver the interventions. This study sought to assess the health system factors affecting access and delivery of IPTp-SP and ITN as defined by the Ghana Malaria Policy Guideline to eligible pregnant women attending ANC clinic sessions.

Assessment of malaria infection among pregnant women and children below five years of age attending rural health facilities of Kenya: A cross-sectional survey in two counties of Kenya

September 23, 2021 - 10:28 -- Open Access
Okoyo C, Githinji E, Muia RW, Masaku J, Mwai J, Nyandieka L, Munga S, Njenga SM, Kanyi HM
PLoS One. 2021 Sep 16;16(9):e0257276

In Kenya, health service delivery and access to health care remains a challenge for vulnerable populations, particularly pregnant women and children below five years. The aim of this study, therefore, was to determine the positivity rate of Plasmodium falciparum parasites in pregnant women and children below five years of age seeking healthcare services at the rural health facilities of Kwale and Siaya counties as well as their access and uptake of malaria control integrated services, like antenatal care (ANC), offered in those facilities.

Novel transdermal bioadhesive surfactant-based system for release and solubility improvement of antimalarial drugs Artemether-Lumefantrine

September 23, 2021 - 08:35 -- Open Access
Volpe-Zanutto F, Fonseca-Santos B, Foglio MA, et al.
Biomed Mater. 2021 Sep 20

Artemether (ART) and lumefantrine (LUM) are the gold standard antimalarial drugs used for the treatment of malaria in children and pregnant women. Typically, ART and LUM are delivered orally in the form of a combined tablet, however, the appropriateness of this route of administration for these drugs is questionable due to the poor absorption and therefore bioavailability observed unless administered alongside lipid-rich foods.Transdermal drug delivery in the form of a patch-type system has been identified as a viable alternative to the conventional tablet-based therapy.

Risk factors for Plasmodium falciparum infection in pregnant women in Burkina Faso: a community-based cross-sectional survey

September 8, 2021 - 16:23 -- Open Access
Jean Baptiste Yaro, Alphonse Ouedraogo, Amidou Diarra, Salif Sombié, Z. Amidou Ouedraogo, Issa Nébié, Chris Drakeley, Sodiomon B. Sirima, Alfred B. Tiono, Steven W. Lindsay and Anne L. Wilson
Malaria Journal 2021 20:362, 6 September 2021

Malaria in pregnancy remains a public health problem in sub-Saharan Africa. Identifying risk factors for malaria in pregnancy could assist in developing interventions to reduce the risk of malaria in Burkina Faso and other countries in the region.

Individual, community and societal correlates of insecticide treated net use among pregnant women in sub-Saharan Africa: a multi-level analysis

September 1, 2021 - 15:44 -- Open Access
Ameyaw EK
BMC Public Health. 2021 Aug 26;21(1):1592

Malaria in pregnancy is a crucial public health concern due to the enormous risk it poses to maternal and newborn health. The World Health Organisation therefore recommends insecticide-treated net (ITN) for pregnant women. The world over, sub-Saharan Africa bears the highest prevalence of malaria and its associated complications. This study investigated the individual, community and society level factors associated with ITN use among pregnant women in sub-Saharan Africa.

Predictors of knowledge and use of long-lasting insecticidal nets for the prevention of malaria among the pregnant women in Pakistan

August 25, 2021 - 17:27 -- Open Access
Ramesh Kumar, Midhat Farzeen, Jamil Ahmed, Manohar Lal and Ratana Somrongthong
Malaria Journal 2021 20:347, 23 August 2021

Malaria is endemic to Pakistan with high prevalence among pregnant women and linked with maternal anaemia, intrauterine growth retardation, preterm birth, and low birth weight. The use of long-lasting insecticidal nets (LLINs) is a proven and cost-effective intervention preventing malaria among pregnant women. The present study aimed to explore predictors of knowledge and use of LLINs among pregnant women in Pakistan.

NOT Open Access | Changes in the structure of chorioamniotic membrane in patients with malaria in pregnancy

August 25, 2021 - 16:15 -- NOT Open Access
Singoei M, Obimbo MM, Odula PO, Gitaka J, Ongidi IH
Placenta. 2021 Aug 18;114:42-49

Malaria infection in pregnancy has adverse consequences for both fetal and maternal health. There is insufficient data on the effect malaria in pregnancy has on the structure of the chorioamniotic membrane. Our objective was to determine the structure of the chorioamniotic membrane in patients with malaria in pregnancy.

Reduced risk of placental parasitemia associated with complement fixation on Plasmodium falciparum by antibodies among pregnant women

August 25, 2021 - 16:09 -- Open Access
Opi DH, Boyle MJ, McLean ARD, Reiling L, Chan JA, Stanisic DI, Ura A, Mueller I, Fowkes FJI, Rogerson SJ, Beeson JG
BMC Med. 2021 Aug 24;19(1):201

The pathogenesis of malaria in pregnancy (MiP) involves accumulation of P. falciparum-infected red blood cells (pRBCs) in the placenta, contributing to poor pregnancy outcomes. Parasite accumulation is primarily mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). Magnitude of IgG to pRBCs has been associated with reduced risk of MiP in some studies, but associations have been inconsistent. Further, antibody effector mechanisms are poorly understood, and the role of antibody complement interactions is unknown.


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