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pregnant women

COVID-19 and the impact on malaria

June 2, 2020 - 09:36 -- Open Access
Author(s): 
Chiodini J
Reference: 
Travel Med Infect Dis. 2020 May 29:101758

As COVID -19 continues to dominate the health and political agendas in so many countries around the world, so does its devastating impact on other diseases become apparent. Malaria is just one of these.

Prevalence of pfdhfr and pfdhps mutations in Plasmodium falciparum associated with drug resistance among pregnant women receiving IPTp-SP at Msambweni County Referral Hospital, Kwale County, Kenya

May 25, 2020 - 08:53 -- Open Access
Author(s): 
Stella Wanjiku Gikunju, Eric L. Agola, Raphael Omusebe Ondondo, Johnson Kinyua, Francis Kimani, Angelle Desiree LaBeaud, Indu Malhotra, Charles King, Kelvin Thiong’o and Francis Mutuku
Reference: 
Malaria Journal 2020 19:190, 24 May 2020

Prevention and treatment of malaria during pregnancy is crucial in dealing with maternal mortality and adverse fetal outcomes. The World Health Organization recommendation to treat all pregnant women with sulfadoxine-pyrimethamine (SP) through antenatal care structures was implemented in Kenya in the year 1998, but concerns about its effectiveness in preventing malaria in pregnancy has arisen due to the spread of SP resistant parasites. This study aimed to determine the prevalence of SP resistance markers in Plasmodium falciparum parasites isolated from pregnant women seeking antenatal care at Msambweni County Referral Hospital, located in coastal Kenya, between the year 2013 and 2015.

Prevalence and clinical impact of malaria infections detected with a highly sensitive HRP2 rapid diagnostic test in Beninese pregnant women

May 25, 2020 - 08:47 -- Open Access
Author(s): 
Valérie Briand, Gilles Cottrell, Nadine Fievet, et al.
Reference: 
Malaria Journal 2020 19:188, 24 May 2020

While sub-microscopic malarial infections are frequent and potentially deleterious during pregnancy, routine molecular detection is still not feasible. This study aimed to assess the performance of a Histidine Rich Protein 2 (HRP2)-based ultrasensitive rapid diagnostic test (uRDT, Alere Malaria Ag Pf) for the detection of infections of low parasite density in pregnant women.

Improving the effectiveness of point of care tests for malaria and anaemia: a qualitative study across three Ghanaian antenatal clinics

May 21, 2020 - 06:37 -- Open Access
Author(s): 
Palmer T, Aiyenigba AO, Bates I, Okyere DD, Tagbor H, Ampofo GD
Reference: 
BMC Health Serv Res. 2020 May 19; 20(1):444

Anaemia and malaria are both major contributors to maternal and child mortality, and morbidity, with some of the worst outcomes occurring in sub-Saharan Africa. Point of care tests (POCT), if used appropriately, provide a simple, inexpensive form of diagnostic testing, as a reliable alternative when laboratory tests are not readily available. In such resource limited settings, clinical staff tend to rely on symptom-based diagnosis and presumptive treatment. This study uses qualitative methods to identify the current practice of POCT use for malaria and anaemia, to explore the enablers and barriers to effective implementation of these POCT, and to determine how relationships between each of the stakeholder groups may impact on POCT use.

Histopathological lesions and exposure to Plasmodium falciparum infections in the placenta increases the risk of preeclampsia among pregnant women

May 21, 2020 - 06:23 -- Open Access
Author(s): 
Obiri D, Erskine IJ, Oduro D, Kusi KA, Amponsah J, Gyan BA, Adu-Bonsaffoh K, Ofori MF
Reference: 
Sci Rep. 2020 May 19; 10(1):8280

Preeclampsia (PE) is a placental disorder with different phenotypic presentations. In malaria-endemic regions, high incidence of PE is reported, with debilitating foeto-maternal effects, particularly among primigravid women. However, the relationship between placental pathology and Plasmodium falciparum infection in the placenta with PE is underexplored.

Molecular surveillance of the Pfmdr1 N86Y allele among Congolese pregnant women with asymptomatic malaria

May 12, 2020 - 16:39 -- Open Access
Author(s): 
Louis Regis Dossou-Yovo, Francine Ntoumi, Felix Koukouikila-Koussounda, Jeannhey Christevy Vouvoungui, Ayodele Adedoja, David Nderu, Thirumalaisamy P. Velavan and Arsène Lenga
Reference: 
Malaria Journal 2020 19:178, 8 May 2020

Malaria in pregnancy is associated with considerable morbidity and mortality. Regular surveillance of artemisinin-based combination therapy tolerance, or molecular makers of resistance, is vital for effective malaria treatment, control and eradication programmes. Plasmodium falciparum multiple drug resistance-1 gene (Pfmdr1) N86Y mutation is associated with reduced susceptibility to lumefantrine. This study assessed the prevalence of Pfmdr1 N86Y in Brazzaville, Republic of Congo.

Prevalence and Correlates of Asymptomatic Malaria and Anemia on First Antenatal Care Visit among Pregnant Women in Southeast, Tanzania

May 6, 2020 - 15:54 -- Open Access
Author(s): 
Mlugu EM, Minzi O, Kamuhabwa AAR, Aklillu E
Reference: 
Int J Environ Res Public Health. 2020 Apr 30;17(9), pii: E3123.

Asymptomatic malaria and anemia during pregnancy increase the risk of negative birth outcomes. This cross-sectional study investigated the prevalence and correlates of asymptomatic malaria and anemia during first antenatal care (ANC) visit among pregnant women in a rural district, Tanzania. HIV-uninfected pregnant women without symptoms of malaria (n = 819) attending their first ANC at Kibiti Health Centre were enrolled from February 2017 to February 2018.

Malaria knowledge and experiences with community health workers among recently pregnant women in Malawi

April 17, 2020 - 14:24 -- Open Access
Author(s): 
Ashley Malpass, Jobiba Chinkhumba, Julie R. Gutman, et al.
Reference: 
Malaria Journal 2020 19:154, 15 April 2020

The World Health Organization recommends three or more doses of intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) to mitigate the negative effects of malaria in pregnancy (MIP). Many pregnant women in Malawi are not receiving the recommended number of doses. Community delivery of IPTp (cIPTp) is being piloted as a new approach to increase coverage. This survey assessed recently pregnant women’s knowledge of MIP and their experiences with community health workers (CHWs) prior to implementing cIPTp.

Trend of declining bed net utilization among pregnant women in Ethiopia: new data from the Arba Minch Health and Demographic Surveillance System, 2010–2016

April 13, 2020 - 13:42 -- Open Access
Author(s): 
Teklemariam Gultie, Gistane Ayele, Alazar Baharu, et al.
Reference: 
Malaria Journal 2020 19:142, 8 April 2020

Bed net utilization is one of the important methods of malaria prevention. Malaria during pregnancy is one of the fatal diseases which mostly leads to the death of the mother and the fetus. Some of the complications of malaria during pregnancy are: intrauterine growth restrictions, intrauterine fetal death, and stillbirth. The main challenge of malaria treatment is that most of the anti-malarial drugs are not safe to use during pregnancy. The use of bed net is the most effective method of prevention of malaria during pregnancy. There is a paucity of information on bed net utilization among pregnant women in the study setting. Hence, this study aims to assess the trends of bed net utilization among pregnant women in Arba Minch Health and Demography Surveillance Site (HDSS), Southern Ethiopia.

NOT Open Access | Regional variation and demographic factors associated with knowledge of malaria risk and prevention strategies among pregnant women in Nigeria

April 6, 2020 - 08:41 -- NOT Open Access
Author(s): 
Iyanda AE, Osayomi T, Boakye KA, Lu Y
Reference: 
Women & Health, Volume 60, 2020 - Issue 4

Pregnant women and children are the most vulnerable populations for malaria infection. Yet, knowledge of risk, and preventive measures are poor among this population. Using the 2015 Nigeria Malaria Indicator Survey, we applied logit link function to estimate the associations of wealth status, educational attainment, and region of residence with malaria risk knowledge and prevention strategies (using a treated mosquito net and malaria drugs) among 739 Nigerian pregnant women aged 15–49 years.

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