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drug resistance

Not Open Access | Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

December 16, 2019 - 16:15 -- NOT Open Access
Author(s): 
Jonathan Kim, Yong Zi Tan, Filippo Mancia, et al.
Reference: 
Nature volume 576, pages315–320(2019)

The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts to control and eliminate malaria. For decades, treatment of malaria has relied on chloroquine (CQ), a safe and affordable 4-aminoquinoline that was highly effective against intra-erythrocytic asexual blood-stage parasites, until resistance arose in Southeast Asia and South America and spread worldwide1.

The genomic architecture of antimalarial drug resistance

November 26, 2019 - 20:17 -- Open Access
Author(s): 
Annie N Cowell, Elizabeth A Winzeler
Reference: 
Briefings in Functional Genomics, Volume 18, Issue 5, September 2019, Pages 314–328

Plasmodium falciparum and Plasmodium vivax, the two protozoan parasite species that cause the majority of cases of human malaria, have developed resistance to nearly all known antimalarials. The ability of malaria parasites to develop resistance is primarily due to the high numbers of parasites in the infected person’s bloodstream during the asexual blood stage of infection in conjunction with the mutability of their genomes.

A comprehensive analysis of drug resistance molecular markers and Plasmodium falciparum genetic diversity in two malaria endemic sites in Mali

November 18, 2019 - 16:29 -- Open Access
Author(s): 
Seidina A. S. Diakité, Karim Traoré, Nafomon Sogoba, et al.
Reference: 
Malaria Journal 2019 18:361, 12 November 2019

Drug resistance is one of the greatest challenges of malaria control programme in Mali. Recent advances in next-generation sequencing (NGS) technologies provide new and effective ways of tracking drug-resistant malaria parasites in Africa. 

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Not Open Access | Molecular Surveillance of Drug Resistance of Plasmodium falciparum Isolates Imported from Angola in Henan Province, China

September 30, 2019 - 13:26 -- NOT Open Access
Author(s): 
Ruimin Zhou, Chengyun Yang, Suhua Li, Yuling Zhao, Ying Liu, Dan Qian, Hao Wang, Deling Lu, Hongwei Zhang and Fang Huang
Reference: 
Antimicrob. Agents Chemother. September 2019 63:e00552-19

Angola was the main origin country for the imported malaria in Henan Province, China.

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NOT Open Access | Within-Host Selection of Drug Resistance in a Mouse Model of Repeated Incomplete Malaria Treatment: Comparison between Atovaquone and Pyrimethamine

January 20, 2016 - 15:04 -- NOT Open Access
Author(s): 
Suci Nuralitha, Josephine E. Siregar, Din Syafruddin, Jessica Roelands, Jan Verhoef, Andy I. M. Hoepelman, and Sangkot Marzuki
Reference: 
Antimicrob. Agents Chemother. January 2016 vol. 60 no. 1 258-263

The evolutionary selection of malaria parasites within individual hosts is an important factor in the emergence of drug resistance but is still not well understood.

Effective Coverage and Systems Effectiveness for Malaria Case Management in Sub-Saharan African Countries

June 2, 2015 - 13:46 -- Open Access
Author(s): 
Katya Galactionova, Fabrizio Tediosi, Don de Savigny, Thomas Smith, Marcel Tanner
Reference: 
PLoS ONE 10(5): e0127818

Scale-up of malaria preventive and control interventions over the last decade resulted in substantial declines in mortality and morbidity from the disease in sub-Saharan Africa and many other parts of the world.

Frequency and correlates of malaria over-treatment in areas of differing malaria transmission: a cross-sectional study in rural Western Kenya

March 5, 2015 - 17:44 -- Open Access
Author(s): 
Frankline M Onchiri, Patricia B Pavlinac, Benson O Singa, Jacqueline M Naulikha, Elizabeth A Odundo, Carey Farquhar, Barbra A Richardson, Grace John-Stewart, Judd L Walson
Reference: 
Malaria Journal 2015, 14:97 (1 March 2015)

Malaria over-treatment was common, particularly in Homa Bay, where the prevalence of malaria was extremely high.

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