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antimalarial drugs

Metal-chloroquine derivatives as possible anti-malarial drugs: evaluation of anti-malarial activity and mode of action

December 15, 2014 - 12:30 -- Open Access
Author(s): 
Maribel Navarro, William Castro, Marilyn Madamet, Rémy Amalvict, Nicolas Benoit, Bruno Pradines
Reference: 
Malaria Journal 2014, 13:471 (3 December 2014)

The high anti-malarial activity displayed for these metal-CQ and metal-CQDP complexes (1-6) could be attributable to their effective interaction with haem and the inhibition of beta-haematin formation in both aqueous medium and near water/n-octanol interfaces at pH 5.

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