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antimalarial drugs

NOT Open Access | Consequences of restricting antimalarial drugs to rapid diagnostic test‐positive febrile children in south‐west Nigeria

November 18, 2019 - 16:12 -- NOT Open Access
Author(s): 
Catherine Olufunke Falade, Adebola Emanuel Orimadegun, Daniel Chandramohan, et al.
Reference: 
Tropical Medicine International Health, Volume24, Issue 11 November 2019 : 1291-1300

To investigate the consequence of restricting antimalarial treatment to febrile children that test positive to a malaria rapid diagnostic test (MRDT) only in an area of intense malaria transmission.

NOT Open Access | Changing Antimalarial Drug Sensitivities in Uganda

November 25, 2017 - 14:50 -- NOT Open Access
Author(s): 
Stephanie A. Rasmussen, Frida G. Ceja, Roland A. Cooper, et al.
Reference: 
Antimicrob. Agents Chemother. December 2017 vol. 61 no. 12 e01516-17

Dihydroartemisinin-piperaquine (DP) has demonstrated excellent efficacy for the treatment and prevention of malaria in Uganda.

Country: 

NOT Open Access | Adaptation and optimization of a fluorescence-based assay for in vivo antimalarial drug screening

June 27, 2017 - 18:05 -- NOT Open Access
Author(s): 
Maria H. Arias, Eric Deharo, Alexis Valentin & Giovanny Garavito
Reference: 
Parasitology Research, July 2017, Volume 116, Issue 7, pp 1955–1962

The in vivo efficacy of potential antimalarials is usually evaluated by direct microscopic determination of the parasitaemia of Plasmodium-infected mice on Giemsa-stained blood smears.

Exploring the role of socioeconomic factors in the development and spread of anti-malarial drug resistance: a qualitative study

May 23, 2017 - 18:14 -- Open Access
Author(s): 
Philip Emeka Anyanwu, John Fulton, Etta Evans and Timothy Paget
Reference: 
Malaria Journal 2017 16:203, 18 May 2017

Social and economic contexts can influence behaviours as they contribute in shaping norms and in creating opportunities that promote certain behaviours.

Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale

February 22, 2017 - 14:49 -- Open Access
Author(s): 
André Golldack, Björn Henke, Bärbel Bergmann, Marie Wiechert, Holger Erler, Alexandra Blancke Soares, Tobias Spielmann, Eric Beitz
Reference: 
PLoS Pathog 13(2): e1006172

Resistance against all available antimalarial drugs calls for novel compounds that hit unexploited targets in the parasite.

Incorporating Stage-Specific Drug Action into Pharmacological Modeling of Antimalarial Drug Treatment

April 27, 2016 - 16:58 -- Open Access
Author(s): 
Eva Maria Hodel, Katherine Kay, and Ian M. Hastings
Reference: 
Antimicrob. Agents Chemother. May 2016 vol. 60 no. 5 2747-2756

Pharmacological modeling of antiparasitic treatment based on a drug's pharmacokinetic and pharmacodynamic properties plays an increasingly important role in identifying optimal drug dosing regimens and predicting their potential impact on control and elimination programs

NOT Open Access | Oral treatments of Echinococcus multilocularis-infected mice with the antimalarial drug mefloquine that potentially interacts with parasite ferritin and cystatin

November 10, 2015 - 12:43 -- NOT Open Access
Author(s): 
Tatiana Küster, Britta Stadelmann, Reto Rufener, Corina Risch, Joachim Müller, Andrew Hemphill
Reference: 
International Journal of Antimicrobial Agents, Volume 46, Issue 5, November 2015, Pages 546–551

This study investigated the effects of oral treatments of Echinococcus multilocularis-infected mice with the antimalarial drug mefloquine (MEF) and identified proteins that bind to MEF in parasite extracts and human cells by affinity chromatography.

Lead Clinical and Preclinical Antimalarial Drugs Can Significantly Reduce Sporozoite Transmission to Vertebrate Populations

December 31, 2014 - 06:31 -- Open Access
Author(s): 
L. M. Upton, P. M. Brock, T. S. Churcher, A. C. Ghani, P. W. Gething, M. J. Delves, K. A. Sala, D. Leroy, R. E. Sinden, and A. M. Blagborough
Reference: 
Antimicrob. Agents Chemother. January 2015 vol. 59 no. 1 490-497

To achieve malarial elimination, we must employ interventions that reduce the exposure of human populations to infectious mosquitoes.

Medical Treatment: 

Efficacy of artesunate-amodiaquine for the treatment of acute uncomplicated falciparum malaria in southern Mauritania

December 22, 2014 - 09:51 -- Open Access
Author(s): 
Ouldabdallahi M, Alew I, Salem MS, dit Dialaw Ba M, Boukhary AO, Khairy ML, Aziz MB, Ringwald P, Basco LK, Niang SD, Lebatt SM
Reference: 
Malaria Journal 2014, 13 :496 (16 December 2014)

Artesunate-amodiaquine is well tolerated and highly efficacious for the treatment of uncomplicated P. falciparum malaria. In the majority of patients, fever and parasitaemia were rapidly cleared before day 3.

Medical Treatment: 

Metal-chloroquine derivatives as possible anti-malarial drugs: evaluation of anti-malarial activity and mode of action

December 15, 2014 - 12:30 -- Open Access
Author(s): 
Maribel Navarro, William Castro, Marilyn Madamet, Rémy Amalvict, Nicolas Benoit, Bruno Pradines
Reference: 
Malaria Journal 2014, 13:471 (3 December 2014)

The high anti-malarial activity displayed for these metal-CQ and metal-CQDP complexes (1-6) could be attributable to their effective interaction with haem and the inhibition of beta-haematin formation in both aqueous medium and near water/n-octanol interfaces at pH 5.

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