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plasmodium falciparium

Prevalence of Plasmodium parasites in non-human primates and mosquitoes in areas with different degrees of fragmentation in Colombia

August 19, 2019 - 18:04 -- Open Access
Silvia Rondón, Cielo León, Andrés Link and Camila González
Malaria Journal 2019 18:276, 19 August 2019

Parasites from the genus Plasmodium, the aetiological agent of malaria in humans, can also infect non-human primates (NHP), increasing the potential risk of zoonotic transmission with its associated global public health concerns. In Colombia, there are no recent studies on Plasmodium spp. infecting free-ranging NHP. Thus, this study aimed to determine the diversity of Plasmodium species circulating in fragmented forests in central Colombia, both in Anopheles mosquitoes and in the four sympatric NHP in the region (Ateles hybridus, Cebus versicolor, Alouatta seniculus and Aotus griseimembra), in order to evaluate the risk of infection to humans associated with the presence of sylvatic hosts and vectors infected with Plasmodium spp.


Diversity and immune responses against Plasmodium falciparum gametocytes in non-febrile school children living in Southern Ghana

August 6, 2019 - 16:12 -- Open Access
Linda E. Amoah, Hamza B. Abagna, Ruth Ayanful-Torgby, Samuel O. Blankson and Nii A. Aryee
Malaria Journal 2019 18:265, 1 August 2019

Natural exposure to gametocytes can result in the development of immunity against the gametocyte by the host as well as genetic diversity in the gametocyte. This study evaluated the quantity and quality of natural immune responses against a gametocyte antigen, Pfs230 as well as the prevalence and diversity of gametocytes circulating in children living in two communities in southern Ghana.


NOT Open Access | Ivermectin Impairs the Development of Sexual and Asexual Stages of Plasmodium falciparum In Vitro

July 29, 2019 - 15:20 -- NOT Open Access
Lais Pessanha de Carvalho, Thaisa Lucas Sandri, Edésio José Tenório de Melo, Rolf Fendel, Peter G. Kremsner, Benjamin Mordmüller and Jana Held
Antimicrob. Agents Chemother. July 2019 63:e00085-19

Ivermectin is the drug of choice for many parasitic infections, with more than one billion doses being distributed in onchocerciasis programs.

Performance of an ultra-sensitive Plasmodium falciparum HRP2-based rapid diagnostic test with recombinant HRP2, culture parasites, and archived whole blood samples

March 20, 2018 - 14:24 -- Open Access
Smita Das, Roger B. Peck, Rebecca Barney, Ihn Kyung Jang, Maria Kahn, Meilin Zhu and Gonzalo J. Domingo
Malaria Journal 2018 17:118, 17 March 2018

The performance of the uRDT was variable depending on the protein, but overall showed a greater than 10-fold improvement over the SD-RDT.

Medical Treatment: 

Population genetic structure and natural selection of Plasmodium falciparum apical membrane antigen-1 in Myanmar isolates

February 13, 2018 - 15:27 -- Open Access
Jung-Mi Kang, Jinyoung Lee, Byoung-Kuk Na, et al.
Malaria Journal 2018 17:71, 7 February 2018

Myanmar PfAMA-1 showed similar patterns of nucleotide diversity and amino acid polymorphisms compared to those of global PfAMA-1.


The prevalence, incidence and prevention of Plasmodium falciparum infections in forest rangers in Bu Gia Map National Park, Binh Phuoc province, Vietnam: a pilot study

November 8, 2017 - 15:24 -- Open Access
Do Hung Son, Nguyen Thuy-Nhien, Tran Tinh Hien, et al.
Malaria Journal 2017 16:444, 6 November 2017

Anti-malarial prophylaxis in forest rangers is feasible.

Effect of stable and fluctuating temperatures on the life history traits of Anopheles arabiensis and An. quadriannulatus under conditions of inter- and intra-specific competition

June 16, 2016 - 14:50 -- Open Access
Davies C, Coetzee M, Lyons C
Parasites & Vectors 2016, 9:342 (14 June 2016)

The effects of environmental temperature on the hatch rate, survivorship and development rate of Anopheles arabiensis and An. quadriannulatus under conditions of inter- and intra-specific competition are studied.

Spatial distribution and cluster analysis of retail drug shop characteristics and antimalarial behaviors as reported by private medicine retailers in western Kenya: informing future interventions

February 23, 2016 - 14:28 -- Open Access
Rusk A, Highfield L, Wilkerson JM, Harrell M, Obala A, Amick B
International Journal of Health Geographics 2016, 15 :9 (19 February 2016)

This research conducted cluster analysis on medicine retailer behaviors in Kenya, to improve malaria case management and inform future interventions.

NOT Open Access | Characterization of native PfABCG protein in Plasmodium falciparum

September 3, 2015 - 15:23 -- NOT Open Access
Sonia Edaye, Elias Georges
Biochemical Pharmacology, Volume 97, Issue 2, 15 September 2015, Pages 137–146

The Plasmodium falciparum genome encodes 16 members of ABC proteins, with one member of the ABCG subfamily (PfABCG). Analysis of PfABCG amino acid sequence shows equal sequence identity to hsABCG1 and G2.

Stool microbiota composition is associated with the prospective risk of Plasmodium falciparum infection

August 25, 2015 - 14:31 -- Open Access
Shibu Yooseph, Ewen F. Kirkness, Karen E. Nelson, et al.
BMC Genomics 2015, 16:631

These findings underscore the diversity of gut microbiota across geographic regions, and suggest that strategic modulation of gut microbiota composition could decrease the risk of P. falciparum infection in malaria-endemic areas, potentially as an adjunct to partially effective malaria vaccines.


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