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plasmodium falciparium

Performance of an ultra-sensitive Plasmodium falciparum HRP2-based rapid diagnostic test with recombinant HRP2, culture parasites, and archived whole blood samples

March 20, 2018 - 14:24 -- Open Access
Smita Das, Roger B. Peck, Rebecca Barney, Ihn Kyung Jang, Maria Kahn, Meilin Zhu and Gonzalo J. Domingo
Malaria Journal 2018 17:118, 17 March 2018

The performance of the uRDT was variable depending on the protein, but overall showed a greater than 10-fold improvement over the SD-RDT.

Medical Treatment: 

Population genetic structure and natural selection of Plasmodium falciparum apical membrane antigen-1 in Myanmar isolates

February 13, 2018 - 15:27 -- Open Access
Jung-Mi Kang, Jinyoung Lee, Byoung-Kuk Na, et al.
Malaria Journal 2018 17:71, 7 February 2018

Myanmar PfAMA-1 showed similar patterns of nucleotide diversity and amino acid polymorphisms compared to those of global PfAMA-1.


The prevalence, incidence and prevention of Plasmodium falciparum infections in forest rangers in Bu Gia Map National Park, Binh Phuoc province, Vietnam: a pilot study

November 8, 2017 - 15:24 -- Open Access
Do Hung Son, Nguyen Thuy-Nhien, Tran Tinh Hien, et al.
Malaria Journal 2017 16:444, 6 November 2017

Anti-malarial prophylaxis in forest rangers is feasible.

Effect of stable and fluctuating temperatures on the life history traits of Anopheles arabiensis and An. quadriannulatus under conditions of inter- and intra-specific competition

June 16, 2016 - 14:50 -- Open Access
Davies C, Coetzee M, Lyons C
Parasites & Vectors 2016, 9:342 (14 June 2016)

The effects of environmental temperature on the hatch rate, survivorship and development rate of Anopheles arabiensis and An. quadriannulatus under conditions of inter- and intra-specific competition are studied.

Spatial distribution and cluster analysis of retail drug shop characteristics and antimalarial behaviors as reported by private medicine retailers in western Kenya: informing future interventions

February 23, 2016 - 14:28 -- Open Access
Rusk A, Highfield L, Wilkerson JM, Harrell M, Obala A, Amick B
International Journal of Health Geographics 2016, 15 :9 (19 February 2016)

This research conducted cluster analysis on medicine retailer behaviors in Kenya, to improve malaria case management and inform future interventions.

NOT Open Access | Characterization of native PfABCG protein in Plasmodium falciparum

September 3, 2015 - 15:23 -- NOT Open Access
Sonia Edaye, Elias Georges
Biochemical Pharmacology, Volume 97, Issue 2, 15 September 2015, Pages 137–146

The Plasmodium falciparum genome encodes 16 members of ABC proteins, with one member of the ABCG subfamily (PfABCG). Analysis of PfABCG amino acid sequence shows equal sequence identity to hsABCG1 and G2.

Stool microbiota composition is associated with the prospective risk of Plasmodium falciparum infection

August 25, 2015 - 14:31 -- Open Access
Shibu Yooseph, Ewen F. Kirkness, Karen E. Nelson, et al.
BMC Genomics 2015, 16:631

These findings underscore the diversity of gut microbiota across geographic regions, and suggest that strategic modulation of gut microbiota composition could decrease the risk of P. falciparum infection in malaria-endemic areas, potentially as an adjunct to partially effective malaria vaccines.

Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity

July 28, 2015 - 14:19 -- Open Access
Duffy C, Assefa S, Abugri J, Amoako N, Owusu-Agyei S, Anyorigiya T, MacInnis B, Kwiatkowski D, Conway D, Awandare G
BMC Genomics 2015, 16 :527 (16 July 2015)

To compare relatively closely situated but ecologically contrasting regions within an endemic African country, population samples of Plasmodium falciparum clinical isolates were collected in Ghana from Kintampo in the central forest-savannah area, and Navrongo in a drier savannah area ~350 km to the north with more seasonally-restricted transmission. 

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum

July 21, 2015 - 16:47 -- Open Access
Wilson DW, Goodman CD, Beeson JG, et al.
BMC Biology 2015, 13 :52 (18 July 2015)

We identified derivatives of azithromycin and erythromycin that are better invasion inhibitors than parent compounds, offering promise for development of this novel antimalarial strategy.

Simultaneous diagnosis of severe imported Plasmodium falciparum malaria and HIV: report of three cases

July 9, 2015 - 06:44 -- Open Access
Nuno Pereira, António Sarmento, Lurdes Santos
Malaria Journal 2015, 14:266 (10 July 2015)

The increasing number of travellers to and from areas where considerable overlap between high malaria transmission and elevated prevalence of human immunodeficiency virus (HIV) infection exists, augment the probability that returning travellers to non-endemic countries might present with both infections.


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