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artemisinin derivatives

NOT Open Access | Parasite viability is a superior measure of anti-malarial drug activity in humans

November 3, 2020 - 15:02 -- NOT Open Access
Rebelo M, Pawliw R, Gower J, Webb L, Mitchell H, Pava Z, Watts RE, Davenport MP, McCarthy JS, Khoury DS
J Infect Dis. 2020 Oct 29:jiaa678

Artemisinin derivatives are the leading class of antimalarial drugs due to their rapid onset of action and rapid clearance of circulating parasites. The parasite clearance (PC) half-life measures the rate of loss of parasites from blood after treatment, and this is currently used to assess antimalarial activity of novel agents and to monitor resistance. However, a number of recent studies have challenged the use of PC to measure drug activity, arguing that many circulating parasites may be non-viable.

NOT Open Access | Absence of association between polymorphisms in the pfcoronin and pfk13 genes and the presence of Plasmodium falciparum parasites after treatment with artemisinin derivatives in Senegal

October 15, 2020 - 08:36 -- NOT Open Access
Delandre O, Daffe SM, Pradines B, et al.
Int J Antimicrob Agents. 2020 Oct 9:106190

Due to resistance to chloroquine and sulfadoxine-pyrimethamine, treatment for uncomplicated Plasmodium falciparum malaria switched to artemisinin-based combination therapy (ACT) in 2006 in Senegal. Several mutations in the gene coding the kelch13 helix (pfk13-propeller) were identified to be associated with in vitro and in vivo artemisinin resistance in Southeast Asia.

Artemisinin Derivatives Stimulate DR5-Specific TRAIL-Induced Apoptosis by Regulating Wildtype P53

September 12, 2020 - 14:54 -- Open Access
Zhou X, Zijlstra SN, Soto-Gamez A, Setroikromo R, Quax WJ
Cancers (Basel). 2020 Sep 4;12(9):E2514

Artemisinin derivatives, widely known as commercial anti-malaria drugs, may also have huge potential in treating cancer cells. It has been reported that artemisinin derivatives can overcome resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in liver and cervical cancer cells. In our study, we demonstrated that artesunate (ATS) and dihydroartemisinin (DHA) are more efficient in killing colon cancer cells compared to artemisinin (ART).

Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97-78 in rat plasma using the HPLC-ESI-MS/MS method: application to drug interaction study

April 24, 2015 - 07:13 -- Open Access
Muhammad Wahajuddin, Sheelendra P Singh, Isha Taneja, Kanumuri Raju, Jiaur R Gayen, Hefazat H Siddiqui, Shio K Singh
Malaria Journal 2015, 14:172 (22 April 2015)

A highly sensitive, specific and reproducible high-throughput LC-ESI-MS/MS assay was developed and validated to quantify lumefantrine and CDRI 97–78

Delayed anemia assessment in patients treated with oral artemisinin derivatives for uncomplicated malaria: a pooled analysis of clinical trials data from Mali

September 19, 2014 - 14:28 -- Open Access
Sagara I, Piarroux R, Djimde A, Giorgi R, Kayentao K, Doumbo OK, Gaudart J
Malaria Journal 2014, 13 :358 (12 September 2014)

A total of 5,990 participants were recruited and followed from day 0 to day 28.

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