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plasmodium infections

NOT Open Access | Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

March 21, 2018 - 14:56 -- NOT Open Access
Author(s): 
Rita Capela, Joana Magalhães, Francisca Lopes, et al.
Reference: 
European Journal of Medicinal Chemistry, Volume 149, 10 April 2018, Pages 69-78

Hybrid compounds may play a critical role in the context of the malaria eradication agenda, which will benefit from therapeutic tools active against the symptomatic erythrocytic stage of Plasmodium infection, and also capable of eliminating liver stage parasites.

Medical Treatment: 

NOT Open Access | IL-6 promotes CD4+ T-cell and B-cell activation during Plasmodium infection

September 23, 2017 - 06:26 -- NOT Open Access
Author(s): 
I.Sebina, L. G. Fogg, K. R. James, M. S. F. Soon, J. Akter, B. S. Thomas, G. R. Hill, C. R. Engwerda and A. Haque
Reference: 
Parasite Immunology, Volume 39, Issue 10, October 2017 e12455

Humoral immunity develops in the spleen during blood-stage Plasmodium infection.

Community-based intermittent mass testing and treatment for malaria in an area of high transmission intensity, western Kenya: study design and methodology for a cluster randomized controlled trial

June 13, 2017 - 16:43 -- Open Access
Author(s): 
Aaron M. Samuels, Nobert Awino, Meghna Desai, et al.
Reference: 
Malaria Journal 2017 16:240, 7 June 2017

Most human Plasmodium infections in western Kenya are asymptomatic and are believed to contribute importantly to malaria transmission.

Country: 

Field Evaluation of a High Throughput Loop Mediated Isothermal Amplification Test for the Detection of Asymptomatic Plasmodium Infections in Zanzibar

January 24, 2017 - 18:18 -- Open Access
Author(s): 
Berit Aydin-Schmidt, Ulrika Morris, Anders Björkman, et al.
Reference: 
PLoS ONE 12(1): e016903

Although field applicable, this high throughput format of LAMP as used here was not sensitive enough to be recommended for detection of asymptomatic low-density infections in areas like Zanzibar, approaching malaria elimination.

Country: 

Natural human Plasmodium infections in major Anopheles mosquitoes in western Thailand

January 16, 2016 - 15:23 -- Open Access
Author(s): 
Sriwichai P, Samung Y, Sumruayphol S, Kiattibutr K, Kumpitak C, Payakkapol A, Kaewkungwal J, Yan G, Cui L, Sattabongkot J
Reference: 
Parasites & Vectors 2016, 9 :17 (13 January 2016)

The four potential vector species all displayed apparent seasonality in relative abundance. While An. minimus s.l. was collected through the entire year, its abundance peaked in the season immediately after the wet season. 

NOT Open Access | 2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

August 27, 2014 - 14:16 -- NOT Open Access
Author(s): 
Néstor M. Carballeira, Angela Gono Bwalya, Deniz Tasdemir, et al.
Reference: 
Bioorganic & Medicinal Chemistry Letters Volume 24, Issue 17, 1 September 2014, Pages 4151–4157

The malaria parasite Plasmodium goes through two life stages in the human host, a non-symptomatic liver stage (LS) followed by a blood stage with all clinical manifestation of the disease.

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