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plasmodium infections

Transcriptome dynamics of CD4(+) T cells during malaria maps gradual transit from effector to memory

October 14, 2020 - 12:33 -- Open Access
Soon MSF, Lee HJ, Haque A, et al.
Nat Immunol. 2020 Oct 12

The dynamics of CD4+ T cell memory development remain to be examined at genome scale. In malaria-endemic regions, antimalarial chemoprevention protects long after its cessation and associates with effects on CD4+ T cells. We applied single-cell RNA sequencing and computational modelling to track memory development during Plasmodium infection and treatment.

NOT Open Access | Efficacy and Safety of a Naphthoquine-Azithromycin Co-Formulation for Malaria Prophylaxis in Southeast Asia: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial

July 21, 2020 - 15:13 -- NOT Open Access
Yang H, Wang J, Cui L, et al.
Clin Infect Dis. 2020 Jul 20:ciaa1018

A prophylactic antimalarial drug that is both effective for protection and improves compliance is in high demand.

Microscopic and submicroscopic Plasmodium infections in indigenous and non-indigenous communities in Colombia

April 20, 2020 - 09:03 -- Open Access
Jehidys Montiel, Lina M. Zuluaga, Daniel C. Aguirre, Cesar Segura, Alberto Tobon-Castaño and Ana M. Vásquez
Malaria Journal 2020 19:157, 16 April 2020

The indigenous population is considered a highly susceptible group to malaria because individuals usually live in areas with high exposure to Anopheles and poverty, and have limited access to health services. There is a great diversity of indigenous communities in Colombia living in malaria-endemic areas; however, the burden of infection in these populations has not been studied extensively. This study aimed to determine the prevalence of Plasmodium infections in indigenous and non-indigenous communities in two malaria-endemic areas in Colombia.

IgG antibody response against Anopheles salivary gland proteins in asymptomatic Plasmodium infections in Narino, Colombia

January 27, 2020 - 13:37 -- Open Access
Jehidys Montiel, Luisa F. Carbal, Alberto Tobón-Castaño, Gissella M. Vásquez, Michael L. Fisher and Berlin Londono-Rentería
Malaria Journal 2020 19:42, 23 January 2020

The humoral immune response against Anopheles salivary glands proteins in the vertebrate host can reflect the intensity of exposure to Anopheles bites and the risk of Plasmodium infection. In Colombia, the identification of exposure biomarkers is necessary due to the several Anopheles species circulating. The purpose of this study was to evaluate risk of malaria infection by measuring antibody responses against salivary glands extracts from Anopheles (Nyssorhynchus) albimanus and Anopheles (Nys.) darlingi and also against the gSG6-P1 peptide of Anopheles gambiae in people residing in a malaria endemic area in the Colombian Pacific coast.

NOT Open Access | Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

March 21, 2018 - 14:56 -- NOT Open Access
Rita Capela, Joana Magalhães, Francisca Lopes, et al.
European Journal of Medicinal Chemistry, Volume 149, 10 April 2018, Pages 69-78

Hybrid compounds may play a critical role in the context of the malaria eradication agenda, which will benefit from therapeutic tools active against the symptomatic erythrocytic stage of Plasmodium infection, and also capable of eliminating liver stage parasites.

Medical Treatment: 

NOT Open Access | IL-6 promotes CD4+ T-cell and B-cell activation during Plasmodium infection

September 23, 2017 - 06:26 -- NOT Open Access
I.Sebina, L. G. Fogg, K. R. James, M. S. F. Soon, J. Akter, B. S. Thomas, G. R. Hill, C. R. Engwerda and A. Haque
Parasite Immunology, Volume 39, Issue 10, October 2017 e12455

Humoral immunity develops in the spleen during blood-stage Plasmodium infection.

Community-based intermittent mass testing and treatment for malaria in an area of high transmission intensity, western Kenya: study design and methodology for a cluster randomized controlled trial

June 13, 2017 - 16:43 -- Open Access
Aaron M. Samuels, Nobert Awino, Meghna Desai, et al.
Malaria Journal 2017 16:240, 7 June 2017

Most human Plasmodium infections in western Kenya are asymptomatic and are believed to contribute importantly to malaria transmission.


Field Evaluation of a High Throughput Loop Mediated Isothermal Amplification Test for the Detection of Asymptomatic Plasmodium Infections in Zanzibar

January 24, 2017 - 18:18 -- Open Access
Berit Aydin-Schmidt, Ulrika Morris, Anders Björkman, et al.
PLoS ONE 12(1): e016903

Although field applicable, this high throughput format of LAMP as used here was not sensitive enough to be recommended for detection of asymptomatic low-density infections in areas like Zanzibar, approaching malaria elimination.


Natural human Plasmodium infections in major Anopheles mosquitoes in western Thailand

January 16, 2016 - 15:23 -- Open Access
Sriwichai P, Samung Y, Sumruayphol S, Kiattibutr K, Kumpitak C, Payakkapol A, Kaewkungwal J, Yan G, Cui L, Sattabongkot J
Parasites & Vectors 2016, 9 :17 (13 January 2016)

The four potential vector species all displayed apparent seasonality in relative abundance. While An. minimus s.l. was collected through the entire year, its abundance peaked in the season immediately after the wet season. 

NOT Open Access | 2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

August 27, 2014 - 14:16 -- NOT Open Access
Néstor M. Carballeira, Angela Gono Bwalya, Deniz Tasdemir, et al.
Bioorganic & Medicinal Chemistry Letters Volume 24, Issue 17, 1 September 2014, Pages 4151–4157

The malaria parasite Plasmodium goes through two life stages in the human host, a non-symptomatic liver stage (LS) followed by a blood stage with all clinical manifestation of the disease.

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