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artemisinin-based combination therapy (ACT)

Therapeutic efficacy of artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria from three highly malarious states in India

October 18, 2016 - 18:21 -- Open Access
Author(s): 
Praveen K. Bharti, Man M. Shukla, Neeru Singh, et al.
Reference: 
Malaria Journal 2016 15:498, 13 October 2016

AL is an efficacious drug for the treatment of uncomplicated falciparum malaria.

Medical Treatment: 

Cost-Effectiveness Analysis of Test-Based versus Presumptive Treatment of Uncomplicated Malaria in Children under Five Years in an Area of High Transmission in Central Ghana

October 11, 2016 - 17:30 -- Open Access
Author(s): 
Theresa Tawiah, Kristian Schultz Hansen, Jayne Webster, et al.
Reference: 
PLoS ONE 11(10): e0164055

The introduction of mRDTs is likely to be considered cost-effective in this high transmission setting as this intervention increased the number of appropriately treated children at low cost.

Person: 

Selection of Plasmodium falciparum pfcrt and pfmdr1 polymorphisms after treatment with artesunate–amodiaquine fixed dose combination or artemether–lumefantrine in Liberia

September 6, 2016 - 18:20 -- Open Access
Author(s): 
Sabina Dahlström Otienoburu, Oumou Maïga-Ascofaré, Sandrine Houzé, et al.
Reference: 
Malaria Journal 2016 15:452, 5 September 2016

Although treatment is highly efficacious, selection of molecular markers in reinfections could indicate a decreased sensitivity or tolerance of parasites to the current treatments and the baseline prevalence of molecular markers should be closely monitored.

Country: 
Medical Treatment: 

Assessing the effects of malaria interventions on the geographical distribution of parasitaemia risk in Burkina Faso

April 23, 2016 - 16:10 -- Open Access
Author(s): 
Eric Diboulo, Ali Sié and Penelope Vounatsou
Reference: 
Malaria Journal 2016 15:228, 21 April 2016

The produced maps show great variations in parasitaemia risk across the country and identify the districts where interventions are being effective.

Country: 

Seeking treatment for uncomplicated malaria: experiences from the Kintampo districts of Ghana

February 23, 2016 - 17:06 -- Open Access
Author(s): 
Lawrence G. Febir, Kwaku Poku Asante, Samuel Afari-Asiedu, Livesy N. Abokyi, Anthony Kwarteng, Bernhards Ogutu, Margaret Gyapong and Seth Owusu-Agyei
Reference: 
Malaria Journal 2016 15:108, 20 February 2016

There is no clear cut trajectory for management of uncomplicated malaria in the study area. Different approaches are adopted when treating malaria.

Country: 
Medical Treatment: 

Do frontline health care providers know enough about artemisinin–based combination therapy to rationally treat malaria? A cross-sectional survey in Gezira State, Sudan

March 31, 2015 - 17:36 -- Open Access
Author(s): 
Abeer A Mannan, Khalid A Elmardi, Yassir A Idris, Jonathan M Spector, Nahid A Ali, Elfatih M Malik
Reference: 
Malaria Journal 2015, 14:131 (26 March 2015)

Overall, ACT knowledge among frontline health care providers is very poor.

Country: 

In vivo efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated falciparum malaria in children: a multisite, open-label, two-cohort, clinical trial in Mozambique

August 19, 2014 - 14:04 -- Open Access
Author(s): 
Nhama A, Bassat Q, Macete E, et al.
Reference: 
Malaria Journal 2014, 13 :309 (10 August 2014)

This study confirms that both AL and ASAQ remain highly efficacious and well tolerated for the treatment of uncomplicated malaria in Mozambican children.

Country: 
Medical Treatment: 

Access to artemisinin-based combination therapy (ACT) and quinine in malaria holoendemic regions of western Kenya

August 15, 2014 - 16:14 -- Open Access
Author(s): 
Watsierah CA, Ouma C
Reference: 
Malaria Journal 2014, 13 :290 (28 July 2014)

These factors determine the adherence to the dosing schedules during the treatment course and thus the evaluation of the subsidy policy, its implementation and role in malaria burden in this region is compulsory.

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