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artemisinin-based combination therapy (ACT)

Efficacy and safety of artemether–lumefantrine as treatment for Plasmodium falciparum uncomplicated malaria in adult patients on efavirenz-based antiretroviral therapy in Zambia: an open label non-randomized interventional trial

May 28, 2019 - 11:31 -- Open Access
Author(s): 
Clifford G. Banda, Mike Chaponda, Victor Mwapasa, et al.
Reference: 
Malaria Journal 2019 18:180, 24 May 2019

HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Artemether–lumefantrine (AL) is the most commonly used ACT for treatment of falciparum malaria in Africa but there is limited evidence on the safety and efficacy of AL in HIV-infected individuals on ART, among whom drug–drug interactions are expected. Day-42 adequate clinical and parasitological response (ACPR) and incidence of adverse events was assessed in HIV-infected individuals on efavirenz-based ART with uncomplicated falciparum malaria treated with AL.

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Malaria testing and treatment knowledge among selected rural patent and proprietary medicine vendors (PPMV) in Nigeria

March 27, 2019 - 16:06 -- Open Access
Author(s): 
Oladimeji Oladepo, Abisoye S. Oyeyemi, Musibau A. Titiloye, Adedayo O. Adeyemi, Sarah M. Burnett, Iorwakwagh Apera, Opeyemi Oladunni and Michael Alliu
Reference: 
Malaria Journal 2019 18:103, 27 March 2019

Substantial knowledge gaps on the use of RDTs and treatment with artemisinin-based combinations exist among rural PPMVs.

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Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in Guinea, 2016

January 30, 2019 - 16:02 -- Open Access
Author(s): 
Alioune Camara, Leah F. Moriarty, Mateusz Plucinski, et al.
Reference: 
Malaria Journal 2019 18:23, 25 January 2019

Although there were more reported adverse events associated with ASAQ when compared with AL, both prescribers and patients were found to be mostly adherent to ACT for the treatment of malaria, regardless of ACT type.

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Adherence to treatment with artemether–lumefantrine or amodiaquine–artesunate for uncomplicated malaria in children in Sierra Leone: a randomized trial

June 5, 2018 - 14:44 -- Open Access
Author(s): 
Kristin Banek, Emily L. Webb, Samuel Juana Smith, Daniel Chandramohan and Sarah G. Staedke
Reference: 
Malaria Journal 2018 17:222, 4 June 2018

Self-reported adherence was high for both AL and AQAS, but varied by site.

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Evaluating malaria case management at public health facilities in two provinces in Angola

May 9, 2017 - 15:48 -- Open Access
Author(s): 
Mateusz M. Plucinski, Manzambi Ferreira, Filomeno Fortes, et al.
Reference: 
Malaria Journal 2017 16:186, 3 May 2017

The results reveal important differences between provinces.

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Effect of anti-malarial interventions on trends of malaria cases, hospital admissions and deaths, 2005–2015, Ghana

May 3, 2017 - 15:14 -- Open Access
Author(s): 
Maru Aregawi, Keziah L. Malm, Constance Bart-Plange, et al.
Reference: 
Malaria Journal 2017 16:177, 26 April 2017

The data provide compelling evidence of impact following LLIN mass campaigns targeting all ages since 2011, while maintaining other anti-malarial interventions.

Therapeutic efficacy of artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria from three highly malarious states in India

October 18, 2016 - 18:21 -- Open Access
Author(s): 
Praveen K. Bharti, Man M. Shukla, Neeru Singh, et al.
Reference: 
Malaria Journal 2016 15:498, 13 October 2016

AL is an efficacious drug for the treatment of uncomplicated falciparum malaria.

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Cost-Effectiveness Analysis of Test-Based versus Presumptive Treatment of Uncomplicated Malaria in Children under Five Years in an Area of High Transmission in Central Ghana

October 11, 2016 - 17:30 -- Open Access
Author(s): 
Theresa Tawiah, Kristian Schultz Hansen, Jayne Webster, et al.
Reference: 
PLoS ONE 11(10): e0164055

The introduction of mRDTs is likely to be considered cost-effective in this high transmission setting as this intervention increased the number of appropriately treated children at low cost.

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Selection of Plasmodium falciparum pfcrt and pfmdr1 polymorphisms after treatment with artesunate–amodiaquine fixed dose combination or artemether–lumefantrine in Liberia

September 6, 2016 - 18:20 -- Open Access
Author(s): 
Sabina Dahlström Otienoburu, Oumou Maïga-Ascofaré, Sandrine Houzé, et al.
Reference: 
Malaria Journal 2016 15:452, 5 September 2016

Although treatment is highly efficacious, selection of molecular markers in reinfections could indicate a decreased sensitivity or tolerance of parasites to the current treatments and the baseline prevalence of molecular markers should be closely monitored.

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Assessing the effects of malaria interventions on the geographical distribution of parasitaemia risk in Burkina Faso

April 23, 2016 - 16:10 -- Open Access
Author(s): 
Eric Diboulo, Ali Sié and Penelope Vounatsou
Reference: 
Malaria Journal 2016 15:228, 21 April 2016

The produced maps show great variations in parasitaemia risk across the country and identify the districts where interventions are being effective.

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