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artemisinin-based combination therapy (ACT)

Parasite clearance, cure rate, post-treatment prophylaxis and safety of standard 3-day versus an extended 6-day treatment of artemether–lumefantrine and a single low-dose primaquine for uncomplicated Plasmodium falciparum malaria in Bagamoyo district, Tan

June 26, 2020 - 15:41 -- Open Access
Author(s): 
Lwidiko E. Mhamilawa, Billy Ngasala, Ulrika Morris, Eliford Ngaimisi Kitabi, Rory Barnes, Aung Paing Soe, Bruno P. Mmbando, Anders Björkman and Andreas Mårtensson
Reference: 
Malaria Journal 2020 19:216, 23 June 2020

Artemisinin-based combination therapy (ACT) resistant Plasmodium falciparum represents an increasing threat to Africa. Extended ACT regimens from standard 3 to 6 days may represent a means to prevent its development and potential spread in Africa.

Coverage of community case management for malaria through CHWs: a quantitative assessment using primary household surveys of high-burden areas in Chhattisgarh state of India

June 26, 2020 - 15:13 -- Open Access
Author(s): 
Samir Garg, Preeti Gurung, Mukesh Dewangan and Prabodh Nanda
Reference: 
Malaria Journal 2020 19:213, 22 June 2020

Community Case Management of Malaria (CCMM) has been implemented through community health workers (CHWs) in many countries. Existing studies have shown that CHWs can be viable means of implementing CCMM. However, not many studies have examined the coverage under large-scale CCMM programmes. India is a big contributor to global malaria burden. Chhattisgarh is a leading state in India in terms of malaria incidence and mortality. CCMM was implemented on a large scale through the ‘mitanin’ CHWs in rural Chhattisgarh from 2015. Under CCMM, 37,696 CHWs in 84 high-burden administrative blocks of the state were trained and equipped with rapid diagnostic tests (RDT), artemisinin-based combination therapy (ACT) and chloroquine.

Early transmission of sensitive strain slows down emergence of drug resistance in Plasmodium vivax

June 23, 2020 - 15:18 -- Open Access
Author(s): 
Ayala MJC, Villela DAM
Reference: 
PLoS Comput Biol 16(6): e1007945

The spread of drug resistance of Plasmodium falciparum and Plasmodium vivax parasites is a challenge towards malaria elimination. P. falciparum has shown an early and severe drug resistance in comparison to P. vivax in various countries. In fact, P. vivax differs in its life cycle and treatment in various factors: development and duration of sexual parasite forms differ, symptoms severity are unequal, relapses present only in P. vivax cases and the Artemisinin-based combination therapy (ACT) is only mandatory in P. falciparum cases.

Molecular assessment of kelch13 non-synonymous mutations in Plasmodium falciparum isolates from Central African Republic (2017–2019)

May 25, 2020 - 08:56 -- Open Access
Author(s): 
Romaric Nzoumbou-Boko, Chris-Boris Gildas Panté-Wockama, Didier Ménard, et al.
Reference: 
Malaria Journal 2020 19:191, 24 May 2020

Over the last decade, artemisinin-based combination therapy (ACT) has contributed substantially to the decrease in malaria-related morbidity and mortality. The emergence of Plasmodium falciparum parasites resistant to artemisinin derivatives in Southeast Asia and the risk of their spread or of local emergence in sub-Saharan Africa are a major threat to public health. This study thus set out to estimate the proportion of P. falciparum isolates, with Pfkelch13 gene mutations associated with artemisinin resistance previously detected in Southeast Asia.

Efficacy and safety of artemether–lumefantrine as treatment for Plasmodium falciparum uncomplicated malaria in adult patients on efavirenz-based antiretroviral therapy in Zambia: an open label non-randomized interventional trial

May 28, 2019 - 11:31 -- Open Access
Author(s): 
Clifford G. Banda, Mike Chaponda, Victor Mwapasa, et al.
Reference: 
Malaria Journal 2019 18:180, 24 May 2019

HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Artemether–lumefantrine (AL) is the most commonly used ACT for treatment of falciparum malaria in Africa but there is limited evidence on the safety and efficacy of AL in HIV-infected individuals on ART, among whom drug–drug interactions are expected. Day-42 adequate clinical and parasitological response (ACPR) and incidence of adverse events was assessed in HIV-infected individuals on efavirenz-based ART with uncomplicated falciparum malaria treated with AL.

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Malaria testing and treatment knowledge among selected rural patent and proprietary medicine vendors (PPMV) in Nigeria

March 27, 2019 - 16:06 -- Open Access
Author(s): 
Oladimeji Oladepo, Abisoye S. Oyeyemi, Musibau A. Titiloye, Adedayo O. Adeyemi, Sarah M. Burnett, Iorwakwagh Apera, Opeyemi Oladunni and Michael Alliu
Reference: 
Malaria Journal 2019 18:103, 27 March 2019

Substantial knowledge gaps on the use of RDTs and treatment with artemisinin-based combinations exist among rural PPMVs.

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Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in Guinea, 2016

January 30, 2019 - 16:02 -- Open Access
Author(s): 
Alioune Camara, Leah F. Moriarty, Mateusz Plucinski, et al.
Reference: 
Malaria Journal 2019 18:23, 25 January 2019

Although there were more reported adverse events associated with ASAQ when compared with AL, both prescribers and patients were found to be mostly adherent to ACT for the treatment of malaria, regardless of ACT type.

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Adherence to treatment with artemether–lumefantrine or amodiaquine–artesunate for uncomplicated malaria in children in Sierra Leone: a randomized trial

June 5, 2018 - 14:44 -- Open Access
Author(s): 
Kristin Banek, Emily L. Webb, Samuel Juana Smith, Daniel Chandramohan and Sarah G. Staedke
Reference: 
Malaria Journal 2018 17:222, 4 June 2018

Self-reported adherence was high for both AL and AQAS, but varied by site.

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Evaluating malaria case management at public health facilities in two provinces in Angola

May 9, 2017 - 15:48 -- Open Access
Author(s): 
Mateusz M. Plucinski, Manzambi Ferreira, Filomeno Fortes, et al.
Reference: 
Malaria Journal 2017 16:186, 3 May 2017

The results reveal important differences between provinces.

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Effect of anti-malarial interventions on trends of malaria cases, hospital admissions and deaths, 2005–2015, Ghana

May 3, 2017 - 15:14 -- Open Access
Author(s): 
Maru Aregawi, Keziah L. Malm, Constance Bart-Plange, et al.
Reference: 
Malaria Journal 2017 16:177, 26 April 2017

The data provide compelling evidence of impact following LLIN mass campaigns targeting all ages since 2011, while maintaining other anti-malarial interventions.

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