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anopheles albimanus

Mosquito metallomics reveal copper and iron as critical factors for Plasmodium infection

June 29, 2021 - 14:13 -- Open Access
Author(s): 
Maya-Maldonado K, Cardoso-Jaime V, González-Olvera G, Osorio B, Recio-Tótoro B, Manrique-Saide P, Rodríguez-Sánchez IP, Lanz-Mendoza H, Missirlis F, Hernández-Hernández FC
Reference: 
PLoS Negl Trop Dis. 2021 Jun 23;15(6):e0009509

Iron and copper chelation restricts Plasmodium growth in vitro and in mammalian hosts. The parasite alters metal homeostasis in red blood cells to its favor, for example metabolizing hemoglobin to hemozoin. Metal interactions with the mosquito have not, however, been studied. Here, we describe the metallomes of Anopheles albimanus and Aedes aegypti throughout their life cycle and following a blood meal. Consistent with previous reports, we found evidence of maternal iron deposition in embryos of Ae. aegypti, but less so in An. albimanus.

Dietary and Plasmodium challenge effects on the cuticular hydrocarbon profile of Anopheles albimanus

June 1, 2021 - 12:39 -- Open Access
Author(s): 
Claudio-Piedras F, Recio-Tótoro B, Cime-Castillo J, Condé R, Maffei M, Lanz-Mendoza H
Reference: 
Sci Rep. 2021 May 27;11(1):11258

The cuticular hydrocarbon (CHC) profile reflects the insects' physiological states. These include age, sex, reproductive stage, and gravidity. Environmental factors such as diet, relative humidity or exposure to insecticides also affect the CHC composition in mosquitoes. In this work, the CHC profile was analyzed in two Anopheles albimanus phenotypes with different degrees of susceptibility to Plasmodium, the susceptible-White and resistant-Brown phenotypes, in response to the two dietary regimes of mosquitoes: a carbon-rich diet (sugar) and a protein-rich diet (blood) alone or containing Plasmodium ookinetes.

Not Open Access | Transcriptome analysis uncover differential regulation in cell cycle, immunity, and metabolism in Anopheles albimanus during immune priming with Plasmodium berghei

February 25, 2021 - 10:27 -- NOT Open Access
Author(s): 
Maya-Maldonado K, Cime-Castillo J, Maya-Lucas O, Argotte-Ramos R, Del Carmen Rodríguez-Gutiérrez M, Lanz-Mendoza H
Reference: 
Dev Comp Immunol. 2021 Feb 15:104046

In invertebrates, "immunological priming" is considered as the ability to acquire a protective (adaptive) immune response against a pathogen due to previous exposure to the same organism. To date, the mechanism by which this type of adaptive immune response originates in insects is not well understood. In the Anopheles albimanus - Plasmodium berghei model, a DNA synthesis that probably indicates an endoreplication process during priming induction has been evidenced.

NOT Open Access | Expression of Heat shock protein 70 (Hsp70-1) in Plasmodium berghei ookinetes and its participation in midgut mosquito infection

November 7, 2020 - 12:32 -- NOT Open Access
Author(s): 
Rodriguez MC, Martínez-Barnetche J, Lecona-Valera AN, Téllez-Sosa J, Argotte-Ramos RS, Alvarado-Delgado A, Ovilla MT, Saldaña-Navor V, Rodriguez MH
Reference: 
Mol Biochem Parasitol. 2020 Nov 1:111337

The heat shock protein family 70 (Hsp70) comprises chaperone proteins that play major multiple roles in Plasmodium asexual and sexual development. In this study, we analyzed the expression of Hsp70-1 in gametocytes, gametes, zygotes, and its participation in ookinete formation and their transition into oocysts. A monoclonal antibody against recombinant Hsp70-1 revealed its presence in zygotes and micronemes of ookinetes.

The Beginning of the End: A Chromosomal Assembly of the New World Malaria Mosquito Ends with a Novel Telomere

September 12, 2020 - 15:10 -- Open Access
Author(s): 
Compton A, Liang J, Chen C, Lukyanchikova V, Qi Y, Potters M, Settlage R, Miller D, Deschamps S, Mao C, Llaca V, Sharakhov IV, Tu Z
Reference: 
G3 (Bethesda). 2020 Sep 3:g3.401654.2020

Chromosome level assemblies are accumulating in various taxonomic groups including mosquitoes. However, even in the few reference-quality mosquito assemblies, a significant portion of the heterochromatic regions including telomeres remain unresolved. Here we produce a de novo assembly of the New World malaria mosquito, Anopheles albimanus by integrating Oxford Nanopore sequencing, Illumina, Hi-C and optical mapping.

Fipronil and ivermectin treatment of cattle reduced the survival and ovarian development of field-collected Anopheles albimanus in a pilot trial conducted in northern Belize

September 3, 2019 - 15:38 -- Open Access
Author(s): 
Staci M. Dreyer, Donovan Leiva, Marla Magaña, Marie Pott, Jonathan Kay, Alvaro Cruz, Nicole L. Achee, John P. Grieco and Jefferson A. Vaughan
Reference: 
Malaria Journal 2019 18:296, 29 August 2019

Most malaria vector control programmes rely on indoor residual spraying of insecticides and insecticide-treated bed nets. This is effective against vector species that feed indoors at night and rest inside the house afterwards. In Central America, malaria vectors have different behaviours and are typically exophagic (i.e., bite outdoors), exophilic (i.e., remain outdoors after feeding), and zoophagic (i.e., as likely to feed on non-humans as humans). Thus, malaria elimination in Central America may require additional tactics. This pilot study investigated whether commercially-available products used to treat livestock for ticks could also be used to kill and/or sterilize zoophagic malaria vectors that feed on treated cattle in Belize.

Country: 

Models of effectiveness of interventions against malaria transmitted by Anopheles albimanus

August 5, 2019 - 16:41 -- Open Access
Author(s): 
Olivier J. T. Briët, Daniel E. Impoinvil, Nakul Chitnis, Emilie Pothin, Jean Frantz Lemoine, Joseph Frederic and Thomas A. Smith
Reference: 
Malaria Journal 2019 18:263, 1 August 2019

Most impact prediction of malaria vector control interventions has been based on African vectors. Anopheles albimanus, the main vector in Central America and the Caribbean, has higher intrinsic mortality, is more zoophilic and less likely to rest indoors. Therefore, relative impact among interventions may be different. Prioritizing interventions, in particular for eliminating Plasmodium falciparum from Haiti, should consider local vector characteristics.

Development of molecular assays to detect target-site mechanisms associated with insecticide resistance in malaria vectors from Latin America

June 24, 2019 - 15:51 -- Open Access
Author(s): 
Juan C. Lol, David Castañeda, Lucy Mackenzie-Impoinvil, Carla G. Romero, Audrey Lenhart and Norma R. Padilla
Reference: 
Malaria Journal 2019 18:202, 20 June 2019

Malaria remains an important public health problem in Latin America, and the development of insecticide resistance in malaria vectors poses a major threat to malaria elimination efforts. Monitoring of insecticide susceptibility and the determination of the mechanisms involved in insecticide resistance are needed to effectively guide the deployment of appropriate vector control measures. Here, molecular assays have been developed to screen for mutations associated with insecticide resistance on the voltage-gated sodium channel (VGSC) and acetylcholinesterase-1 (Ace-1) genes in four malaria vectors from Latin America.

Continent: 
Medical Condition: 

NOT Open Access | Plasmodium berghei induced priming in Anopheles albimanus independently of bacterial co-infection

July 6, 2015 - 12:25 -- NOT Open Access
Author(s): 
Jorge Contreras-Garduno, Maria Carmen Rodriguez, Humberto Lanz-Mendoza, et al.
Reference: 
Developmental & Comparative Immunology, Volume 52, Issue 2, October 2015, Pages 172–181

Priming in invertebrates is the acquired capacity to better combat a pathogen due to a previous exposure to sub-lethal doses of the same organism.

Novel mutations on the ace-1 gene of the malaria vector Anopheles albimanus provide evidence for balancing selection in an area of high insecticide resistance in Peru

March 10, 2015 - 13:26 -- Open Access
Author(s): 
Kelly A Liebman, Jesus Pinto, Jorge Valle, Miriam Palomino, Lucrecia Vizcaino, William Brogdon, Audrey Lenhart
Reference: 
Malaria Journal 2015, 14:74 (14 February 2015)

A single point mutation on the ace-1 gene (G119S) associated with resistance to OPs and CAs has been described previously in four anopheline species, but not in field-collected An. albimanus. The present study aimed to characterize the role of ace-1 in conferring resistance to both OPs and CAs in the An. albimanus population in Tumbes, Peru.

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