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Burkina Faso

Genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in Nanoro, Burkina Faso

February 17, 2021 - 09:04 -- Open Access
Hamatandi Magloire Natama, Eduard Rovira-Vallbona, Anna Rosanas-Urgell, et al.
Malaria Journal 2021 20:94, 16 February 2021

Genetic polymorphisms in the human immune system modulate susceptibility to malaria. However, there is a paucity of data on the contribution of immunogenetic variants to malaria susceptibility in infants, who present differential biological features related to the immaturity of their adaptive immune system, the protective effect of maternal antibodies and fetal haemoglobin. This study investigated the association between genetic variation in innate immune response genes and malaria susceptibility during the first year of life in 656 infants from a birth cohort survey performed in Nanoro, Burkina Faso.

Hepatic safety of repeated treatment with pyronaridine‐artesunate versus artemether–lumefantrine in patients with uncomplicated malaria: a secondary analysis of the WANECAM 1 data from Bobo-Dioulasso, Burkina Faso

February 3, 2021 - 15:08 -- Open Access
Yves Daniel Compaoré, Issaka Zongo, Jean Bosco Ouédraogo, et al.
Malaria Journal 2021 20:64, 29 January 2021

The use of pyronaridine-artesunate (PA) has been associated with scarce transaminitis in patients. This analysis aimed to evaluate the hepatic safety profile of repeated treatment with PA versus artemether–lumefantrine (AL) in patients with consecutive uncomplicated malaria episodes in Bobo-Dioulasso, Burkina Faso.

Quantifying and characterizing hourly human exposure to malaria vectors bites to address residual malaria transmission during dry and rainy seasons in rural Southwest Burkina Faso

February 2, 2021 - 16:58 -- Open Access
Soma DD, Zogo B, Taconet P, Somé A, Coulibaly S, Baba-Moussa L, Ouédraogo GA, Koffi A, Pennetier C, Dabiré KR, Moiroux N
BMC Public Health. 2021 Jan 30;21(1):251

To sustain the efficacy of malaria vector control, the World Health Organization (WHO) recommends the combination of effective tools. Before designing and implementing additional strategies in any setting, it is critical to monitor or predict when and where transmission occurs. However, to date, very few studies have quantified the behavioural interactions between humans and Anopheles vectors in Africa. Here, we characterized residual transmission in a rural area of Burkina Faso where long lasting insecticidal nets (LLIN) are widely used.

Malaria vectors diversity, insecticide resistance and transmission during the rainy season in peri-urban villages of south-western Burkina Faso

January 27, 2021 - 15:52 -- Open Access
Dieudonné Diloma Soma, Serge Bèwadéyir Poda, Roch Kounbobr Dabiré, et al.
Malaria Journal 2021 20:63, 25 January 2021

This study reports an updated description on malaria vector diversity, behaviour, insecticide resistance and malaria transmission in the Diébougou and Dano peri-urban areas, Burkina Faso.

Anti-malarial efficacy and resistance monitoring of artemether-lumefantrine and dihydroartemisinin-piperaquine shows inadequate efficacy in children in Burkina Faso, 2017–2018

January 20, 2021 - 08:38 -- Open Access
Adama Gansané, Leah F. Moriarty, Halidou Tinto, et al.
Malaria Journal 2021 20:48, 19 January 2021

The World Health Organization recommends regularly assessing the efficacy of artemisinin-based combination therapy (ACT), which is a critical tool in the fight against malaria. This study evaluated the efficacy of two artemisinin-based combinations recommended to treat uncomplicated Plasmodium falciparum malaria in Burkina Faso in three sites: Niangoloko, Nanoro, and Gourcy.

Quantifying individual variability in exposure risk to mosquito bites in the Cascades region, Burkina Faso

January 20, 2021 - 08:26 -- Open Access
Federica Guglielmo, Antoine Sanou, Thomas Churcher, Heather M. Ferguson, Hilary Ranson and Ellie Sherrard-Smith
Malaria Journal 2021 20:44, 18 January 2021

The Cascades region, Burkina Faso, has a high malaria burden despite reported high insecticide-treated mosquito net (ITN) use. Human and vector activities outside the hours when indoor interventions offer direct protection from infectious bites potentially increase exposure risk to bites from malaria-transmitting Anopheles mosquitoes. This work investigated the degree of variation in human behaviour both between individuals and through time (season) to quantify how it impacts exposure to malaria vectors.

Insecticide resistance status of malaria vectors Anopheles gambiae (s.l.) of southwest Burkina Faso and residual efficacy of indoor residual spraying with microencapsulated pirimiphos-methyl insecticide

January 20, 2021 - 06:07 -- Open Access
Soma DD, Zogo B, Dabiré RK, et al.
Parasit Vectors. 2021 Jan 18;14(1):58

The rapid spread of insecticide resistance in malaria vectors and the rebound in malaria cases observed recently in some endemic areas underscore the urgent need to evaluate and deploy new effective control interventions. A randomized control trial (RCT) was conducted with the aim to investigate the benefit of deploying complementary strategies, including indoor residual spraying (IRS) with pirimiphos-methyl in addition to long-lasting insecticidal nets (LLINs) in Diébougou, southwest Burkina Faso.

Constructing a malaria-related health service readiness index and assessing its association with child malaria mortality: an analysis of the Burkina Faso 2014 SARA data

January 6, 2021 - 12:44 -- Open Access
Millogo O, Doamba JEO, Sié A, Utzinger J, Vounatsou P
BMC Public Health. 2021 Jan 5;21(1):20

The Service Availability and Readiness Assessment surveys generate data on the readiness of health facility services. We constructed a readiness index related to malaria services and determined the association between health facility malaria readiness and malaria mortality in children under the age of 5 years in Burkina Faso.

Red blood cell homeostasis in children and adults with and without asymptomatic malaria infection in Burkina Faso

December 3, 2020 - 12:24 -- Open Access
Kaboré B, Post A, Berendsen MLT, Diallo S, Lompo P, Derra K, Rouamba E, Jacobs J, Tinto H, de Mast Q, van der Ven AJ
PLoS One. 2020 Nov 30;15(11):e0242507

Asymptomatic malaria infections may affect red blood cell (RBC) homeostasis. Reports indicate a role for chronic hemolysis and splenomegaly, however, the underlying processes are incompletely understood. New hematology analysers provide parameters for a more comprehensive analysis of RBC hemostasis. Complete blood counts were analysed in subjects from all age groups (n = 1118) living in a malaria hyperendemic area and cytokines and iron biomarkers were also measured. Subjects were divided into age groups (<2 years, 2-4, 5-14 and ≥15 years old) and clinical categories (smear-negative healthy subjects, asymptomatic malaria and clinical malaria).

Malaria and curable sexually transmitted infections in pregnant women: A two-years observational study in rural Burkina Faso

November 18, 2020 - 12:03 -- Open Access
Zango SH, Lingani M, Robert A, et al.
PLoS One. 2020 Nov 16;15(11):e0242368

Malaria and curable sexually transmitted infections (STI) are the most common curable infections known to have a severe impact on pregnancy outcomes in sub-Saharan Africa. This study aims to assess the marginal and joint prevalence of symptomatic cases of malaria and STI in pregnant women living in rural settings of Burkina Faso and their associated factors, after more than a decade of the introduction of intermittent preventive treatment (IPT-SP).


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