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Burkina Faso

Malaria Case Fatality Rate among Children under Five in Burkina Faso: An Assessment of the Spatiotemporal Trends Following the Implementation of Control Programs

March 19, 2020 - 08:46 -- Open Access
Author(s): 
Ouédraogo M, Kangoye DT, Samadoulougou S, Rouamba T, Donnen P, Kirakoya-Samadoulougou F
Reference: 
Int J Environ Res Public Health. 2020 Mar 12; 17(6). pii: E1840

Reducing the 2015 level of malaria mortality by 90% by 2030 is a goal set by the World Health Organization (WHO). In Burkina Faso, several malaria control programs proven to be effective were implemented over the last decade. In parallel, the progressive strengthening of the health surveillance system is generating valuable data, which represents a great opportunity for analyzing the trends in malaria burden and assessing the effect of these control programs.

Insecticide-treated bed net access and use among preschool children in Nouna District, Burkina Faso

March 3, 2020 - 15:11 -- Open Access
Author(s): 
Sié A, Bountogo M, Lietman TM, Oldenburg CE, et al.
Reference: 
Int Health. 2020 Feb 29. pii: ihaa003

We evaluated universal insecticide-treated bed net access and use in children <5 y of age in a rural area of Burkina Faso.

NOT Open Access | Proteomic Investigation on Anopheles gambiae in Burkina Faso Related to Insecticide Pressures from Different Climatic Regions

March 3, 2020 - 14:51 -- NOT Open Access
Author(s): 
Zoure AA, Serteyn L, Somda Z, Badolo A, Francis F
Reference: 
Proteomics. 2020 Feb 27:e1900400

In Sub‐Saharan Africa, Anopheles gambiae Giles (Diptera: Culicidae) largely contributes to malaria transmission, in direct relation to environmental conditions influencing the vector ecology. Therefore, we carried out a proteomic analysis on An. gambiae sensu lato (s.l.) mosquitoes to compare their metabolic state, depending on different pesticide pressures by selecting areas with or without cotton crops, in two climatic regions. Adult mosquitoes were collected, and the proteomes were analysed by liquid chromatography with tandem mass spectrometry (LC‐MS/MS).

NOT Open Access | Genetic analysis and population structure of Anopheles gambiae complex (Diptera: Culicidae) from different ecological zones of Burkina Faso

March 2, 2020 - 14:18 -- NOT Open Access
Author(s): 
Zoure AA, Noel G, Sombie A, Somda Z, Badolo A, Francis F
Reference: 
Infect Genet Evol. 2020 Feb 21:104261

The Anopheles gambiae complex is the most important vector for malaria in Sub-Saharan Africa, besides to other vectors such as Anopheles funestus. Malaria vector control must consider specific identification, genetic diversity and population structure of An. gambiae to design vector control strategies.

Bayesian Spatiotemporal Modeling of Routinely Collected Data to Assess the Effect of Health Programs in Malaria Incidence During Pregnancy in Burkina Faso

February 22, 2020 - 16:57 -- Open Access
Author(s): 
Rouamba T, Samadoulougou S, Tinto H, Alegana VA, Kirakoya-Samadoulougou F
Reference: 
Sci Rep. 2020 Feb 14;10(1):2618

Control of malaria in pregnancy (MiP) remains a major challenge in Burkina Faso. Surveillance of the burden due to MiP based on routinely collected data at a fine-scale level, followed by an appropriate analysis and interpretation, may be crucial for evaluating and improving the effectiveness of existing control measures. We described the spatio-temporal dynamics of MiP at the community-level and assessed health program effects, mainly community-based health promotion, results-based financing, and intermittent-preventive-treatment with sulphadoxine-pyrimethamine (IPTp-SP).

P. falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers in Burkina Faso

January 15, 2020 - 09:03 -- Open Access
Author(s): 
Meibalan E, Barry A, Gibbins MP, Awandu S, Meerstein-Kessel L, Achcar F, Bopp S, Moxon C, Diarra A, Debe S, Ouédraogo N, Barry-Some I, Badoum E, Fagnima T, Lanke K, Gonçalves BP, Bradley J, Wirth D, Drakeley C, Guelbeogo WM, Tiono AB, Marti M, Bousema T
Reference: 
The Journal of Infectious Diseases, jiz680

Plasmodium falciparum transmission depends on mature gametocytes that can be ingested by mosquitoes taking a bloodmeal on human skin. Although gametocyte skin sequestration has long been hypothesized as important contributor to efficient malaria transmission, this has never been formally tested.

Genotype Analysis of Clinical Candida albicans Isolates Using PCRs Targeting 25S rDNA and ALT Repeat Sequences of the RPS and Antifungal Susceptibility in Ouagadougou (Burkina Faso)

January 14, 2020 - 12:19 -- Open Access
Author(s): 
Sawadogo PM, Zida A, Soulama I, Sermé SS, Guiguemdé KT, Junior R, Sangaré I, Bamba S, Ouédraogo-Traoré R, Guiguemdé TR
Reference: 
Infection and Drug Resistance, 16 December 2019 Volume 2019:12 Pages 3859—3866

Candida albicans is a yeast with multiple genotypes. It’s a commensal fungus colonizing various sites. However, when the host’s immune system weakens, it becomes pathogenic and is responsible for various lesions. In Burkina Faso, antifungal drugs are frequently used, particularly fluconazole, the most used systemic antifungal. This antifungal drug and other antifungal drugs are often used for self-medication or prescribed outside of antifungal susceptibility test results. These situations led to the emergence of Candida albicans strains resistant to antifungal drugs commonly used in Burkina Faso. The aim of this study was to determine the types of Candida albicans using PCRs targeting 25S rDNA and ALT repeat sequences of the RPS and to establish their azoles and polyenes susceptibility profile.

Anopheles gambiae populations from Burkina Faso show minimal delayed mortality after exposure to insecticide-treated nets

January 14, 2020 - 10:10 -- Open Access
Author(s): 
Hughes A, Lissenden N, Viana M, Toé KH, Ranson H
Reference: 
Parasites Vectors, 2020 Jan 10; 13(1):17

The efficacy of long-lasting insecticidal nets (LLINs) in preventing malaria in Africa is threatened by insecticide resistance. Bioassays assessing 24-hour mortality post-LLIN exposure have established that resistance to the concentration of pyrethroids used in LLINs is widespread. However, although mosquitoes may no longer be rapidly killed by LLIN exposure, a delayed mortality effect has been shown to reduce the transmission potential of mosquitoes exposed to nets. This has been postulated to partially explain the continued efficacy of LLINs against pyrethroid-resistant populations. Burkina Faso is one of a number of countries with very high malaria burdens and pyrethroid-resistant vectors, where progress in controlling this disease has stagnated. We measured the impact of LLIN exposure on mosquito longevity in an area of the country with intense pyrethroid resistance to establish whether pyrethroid exposure was still shortening mosquito lifespan in this setting.

In vivo/ex vivo efficacy of artemether–lumefantrine and artesunate–amodiaquine as first-line treatment for uncomplicated falciparum malaria in children: an open label randomized controlled trial in Burkina Faso

January 7, 2020 - 15:14 -- Open Access
Author(s): 
Moussa Lingani, Léa Nadège Bonkian, Halidou Tinto, et al.
Reference: 
Malaria Journal 2020 19:8, 6 January 2020

Artemisinin-based combination therapy (ACT) is recommended to improve malaria treatment efficacy and limit drug-resistant parasites selection in malaria endemic areas. 5 years after they were adopted, the efficacy and safety of artemether–lumefantrine (AL) and artesunate–amodiaquine (ASAQ), the first-line treatments for uncomplicated malaria were assessed in Burkina Faso.

Bacterial communities associated with the midgut microbiota of wild Anopheles gambiae complex in Burkina Faso

January 7, 2020 - 14:41 -- Open Access
Author(s): 
Zoure AA, Sare AR, Yameogo F, Somda Z, Massart S, Badolo A, Francis F
Reference: 
Molecular Biology Reports January 2020, Volume 47, Issue 1, pp 211–224

Plasmodium falciparum is transmitted by mosquitoes from the Anopheles gambiae sensu lato (s.l) species complex and is responsible for severe forms of malaria. The composition of the mosquitoes’ microbiota plays a role in P. falciparum transmission, so we studied midgut bacterial communities of An. gambiae s.l from Burkina Faso. DNA was extracted from 17 pools of midgut of mosquitoes from the Anopheles gambiae complex from six localities in three climatic areas, including cotton-growing and cotton-free localities to include potential differences in insecticide selection pressure.

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