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Burkina Faso

Is there evidence of anti-malarial multidrug resistance in Burkina Faso?

July 21, 2021 - 17:57 -- Open Access
Charlotte Rasmussen and Pascal Ringwald
Malaria Journal 2021 20:320, 19 July 2021

Recently, Gansané and colleagues published an article on inadequate efficacy of two different forms of artemisinin-based combination therapy (ACT) in Burkina Faso. The development of Plasmodium falciparum resistance to different ACT partner drugs at levels that could affect the efficacy of two ACT would both be startling and a cause for great concern. In reviewing the available data collected since 2008 on ACT efficacy in Burkina Faso, the analysis shows that the reported efficacy of the tested ACT varies greatly.

Data-driven and interpretable machine-learning modeling to explore the fine-scale environmental determinants of malaria vectors biting rates in rural Burkina Faso

June 30, 2021 - 12:44 -- Open Access
Taconet P, Porciani A, Soma DD, Mouline K, Simard F, Koffi AA, Pennetier C, Dabiré RK, Mangeas M, Moiroux N
Parasit Vectors. 2021 Jun 29;14(1):345

Improving the knowledge and understanding of the environmental determinants of malaria vector abundance at fine spatiotemporal scales is essential to design locally tailored vector control intervention. This work is aimed at exploring the environmental tenets of human-biting activity in the main malaria vectors (Anopheles gambiae s.s., Anopheles coluzzii and Anopheles funestus) in the health district of Diébougou, rural Burkina Faso.

Community-based delivery of intermittent preventive treatment of malaria in pregnancy in Burkina Faso: a qualitative study

June 23, 2021 - 14:33 -- Open Access
Danielle Burke, Justin Tiendrebeogo, Courtney Emerson, Susan Youll, Julie Gutman, Ousmane Badolo, Yacouba Savadogo, Kristen Vibbert, Katherine Wolf and William Brieger
Malaria Journal 2021 20:277, 23 June 2021

Burkina Faso is among ten countries with the highest rates of malaria cases and deaths in the world. Delivery and coverage of intermittent preventive treatment of malaria in pregnancy (IPTp) is insufficient in Burkina Faso; In a 2016 survey, only 22% of eligible women had received their third dose of IPTp. It is also an extremely rural country and one with an established cadre of community healthcare workers (CHWs). To better meet the needs of pregnant women, an enhanced programme was established to facilitate distribution of IPTp at the community level by CHWs.

Nutritional status in young children prior to the malaria transmission season in Burkina Faso and Mali, and its impact on the incidence of clinical malaria

June 23, 2021 - 14:05 -- Open Access
Mariken de Wit, Matthew Cairns, Jean Bosco Ouedraogo, et al.
Malaria Journal 2021 20:274, 22 June 2021

Malaria and malnutrition remain major problems in Sahel countries, especially in young children. The direct effect of malnutrition on malaria remains poorly understood, and may have important implications for malaria control. In this study, nutritional status and the association between malnutrition and subsequent incidence of symptomatic malaria were examined in children in Burkina Faso and Mali who received either azithromycin or placebo, alongside seasonal malaria chemoprevention.

Pyriproxyfen-treated bed nets reduce reproductive fitness and longevity of pyrethroid-resistant Anopheles gambiae under laboratory and field conditions

June 23, 2021 - 14:03 -- Open Access
Nelson Grisales, Rosemary S. Lees, Hilary Ranson, et al.
Malaria Journal 2021 20:273, 22 June 2021

The efficacy of insecticide-treated nets (ITNs) containing the insect growth regulator pyriproxyfen (PPF) and pyrethroid insecticides (PPF-ITNs) is being assessed in clinical trials to determine whether they provide greater protection from malaria than standard pyrethroid-treated ITNs in areas where mosquitoes are resistant to pyrethroids. Understanding the entomological mode of action of this new ITN class will aide interpretation of the results from these trials.

Predicting malaria epidemics in Burkina Faso with machine learning

June 22, 2021 - 14:51 -- Open Access
Harvey D, Valkenburg W, Amara A
PLoS One. 2021 Jun 18;16(6):e0253302

Accurately forecasting the case rate of malaria would enable key decision makers to intervene months before the onset of any outbreak, potentially saving lives. Until now, methods that forecast malaria have involved complicated numerical simulations that model transmission through a community. Here we present the first data-driven malaria epidemic early warning system that can predict the 13-week case rate in a primary health facility in Burkina Faso.

Is biological larviciding against malaria a starting point for integrated multi-disease control? Observations from a cluster randomized trial in rural Burkina Faso

June 22, 2021 - 14:22 -- Open Access
Dambach P, Bärnighausen T, Yadouleton A, Dambach M, Traoré I, Korir P, Ouedraogo S, Nikiema M, Sauerborn R, Becker N, Louis VR
PLoS One. 2021 Jun 18;16(6):e0253597

To evaluate the impact of anti-malaria biological larviciding with Bacillus thuringiensis israelensis on non-primary target mosquito species in a rural African setting.

Plasmodium falciparum Gametocyte Density and Infectivity in Peripheral Blood and Skin Tissue of Naturally Infected Parasite Carriers in Burkina Faso

June 1, 2021 - 15:49 -- Open Access
Meibalan E, Barry A, Bousema T, et al.
J Infect Dis. 2021 May 28;223(10):1822-1830

Plasmodium falciparum transmission depends on mature gametocytes that can be ingested by mosquitoes taking a blood meal on human skin. Although gametocyte skin sequestration has long been hypothesized as important contributor to efficient malaria transmission, this has never been formally tested.

Assessment of a combined strategy of seasonal malaria chemoprevention and supplementation with vitamin A, zinc and Plumpy'Doz to prevent malaria and malnutrition in children under 5 years old in Burkina Faso: a randomized open-label trial (SMC-NUT)

May 26, 2021 - 09:44 -- Open Access
Sondo P, Tahita MC, Tinto H, et al.
Trials. 2021 May 24;22(1):360

Malaria and malnutrition represent major public health concerns worldwide especially in Sub-Sahara Africa. Despite implementation of seasonal malaria chemoprophylaxis (SMC), an intervention aimed at reducing malaria incidence among children aged 3–59 months, the burden of malaria and associated mortality among children below age 5 years remains high in Burkina Faso. Malnutrition, in particular micronutrient deficiency, appears to be one of the potential factors that can negatively affect the effectiveness of SMC. Treating micronutrient deficiencies is known to reduce the incidence of malaria in highly prevalent malaria zone such as rural settings. Therefore, we hypothesized that a combined strategy of SMC together with a daily oral nutrients supplement will enhance the immune response and decrease the incidence of malaria and malnutrition among children under SMC coverage.

Laboratory and field evaluation of MAÏA®, an ointment containing N,N-diethyl-3-methylbenzamide (DEET) against mosquitoes in Burkina Faso

May 26, 2021 - 09:13 -- Open Access
Alphonse Traoré, Gérard Niyondiko, Antoine Sanou, Franck Langevin, N’Falé Sagnon, Adama Gansané and Moussa Wamdaogo Guelbeogo
Malaria Journal 2021 20:226, 20 May 2021

Malaria vector control relies upon the use of insecticide-treated nets and indoor residual spraying. However, as the emergency of insecticide resistance in malaria vectors grows, the effectiveness of these measures could be limited. Alternative tools are needed. In this context, repellents can play an important role against exophagic and exophilic mosquitoes. This study evaluated the efficacy of MAÏA®, a novel repellent ointment, in laboratory and field conditions in Burkina Faso.


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