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anti-malaria

Advances in the research on the targets of anti-malaria actions of artemisinin

December 2, 2020 - 09:43 -- Open Access
Author(s): 
Yang J, He Y, Li Y, Zhang X, Wong YK, Shen S, Zhong T, Zhang J, Liu Q, Wang J
Reference: 
Pharmacol Ther. 2020 Dec;216:107697

Malaria has been a global epidemic health threat since ancient times. It still claims roughly half a million lives every year in this century. Artemisinin and its derivatives, are frontline antimalarial drugs known for their efficacy and low toxicity. After decades of wide use, artemisinins remain our bulwark against malaria. Here, we review decades of efforts that aim to understand the mechanism of action (MOA) of artemisinins, which help explain the specificity and potency of this anti-malarial drug.

Chloroquine and Hydroxychloroquine in the Treatment of Malaria and Repurposing in Treating COVID-19

September 15, 2020 - 14:44 -- Open Access
Author(s): 
Lei ZN, Wu ZX, Dong S, Yang DH, Zhang L, Ke Z, Zou C, Chen ZS
Reference: 
Pharmacol Ther. 2020 Sep 7:107672

Chloroquine (CQ) and Hydroxychloroquine (HCQ) have been commonly used for the treatment and prevention of malaria, and the treatment of autoimmune diseases for several decades. As their new mechanisms of actions are identified in recent years, CQ and HCQ have wider therapeutic applications, one of which is to treat viral infectious diseases.

ITEM-THREE analysis of a monoclonal anti-malaria antibody reveals its assembled epitope on the pfMSP119 antigen

September 1, 2020 - 10:05 -- Open Access
Author(s): 
Opuni KFM, Koy C, Russ M, Reepmeyer M, Danquah BD, Weresow M, Alef A, Lorenz P, Thiesen HJ, Glocker MO
Reference: 
J Biol Chem. 2020 Aug 26:jbc.RA120.014802

Rapid diagnostic tests are first line assays for diagnosing infectious diseases, such as malaria. To minimize false positive and false negative test results in population screening assays, high quality reagents and well characterized antigens and antibodies are needed. An important property of antigen - antibody binding is recognition specificity which best can be estimated by mapping an antibody's epitope on the respective antigen.

Stocking pattern for anti-malarial medications among proprietary patent medicine vendors in Akinyele Local Government Area, Ibadan, Nigeria

August 4, 2020 - 16:12 -- Open Access
Author(s): 
Mary Y. Kodaolu, Adeniyi F. Fagbamigbe and IkeOluwapo O. Ajayi
Reference: 
Malaria Journal 2020 19:279, 3 August 2020

Policymakers have recognized that proprietary patent medicine vendors (PPMVs) can provide an opportunity for effective scaling up of artemisinin-based combination therapy (ACT) since they constitute a major source of malaria treatment in Nigeria. This study was designed to determine the stocking pattern for anti-malarial medications, knowledge of the recommended anti-malarial medicine among PPMVs in Akinyele Local Government Area (LGA) of Oyo State, Nigeria and their perception on ways to improve PPMV adherence to stocking ACT medicines.

NOT Open Access | Gaps between Knowledge and Malaria Treatment Practices after Intensive Anti-Malaria Campaigns in Western Kenya: 2004-2016

March 23, 2020 - 14:08 -- NOT Open Access
Author(s): 
Zhou G, Hemming-Schroeder E, Gesuge M, Afrane YA, Lee MC, Atieli HE, Githeko AK, Yan G
Reference: 
Am J Trop Med Hyg. 2020 Mar 16

Effective case management is central for malaria control, but not all of those affected by malaria have access to prompt, effective treatment. In Kenya, free malaria treatment has been implemented since 2006. However, questions remain regarding effective treatment. We conducted cross-sectional epidemiological and questionnaire surveys in four counties in western Kenya in 2004, 2010, and 2016, and antimalarial availability surveys in 2016.

NOT Open Access | Anti-tuberculosis activity of the anti-malaria cytochrome bcc oxidase inhibitor SCR0911

March 2, 2020 - 14:14 -- NOT Open Access
Author(s): 
Chong S, Manimekalai MSS, Sarathy JP, Williams ZC, Harold LK, Cook GM, Dick T, Pethe K, Bates RW, Grüber G
Reference: 
ACS Infect Dis. 2020 Feb 24

The ability to respire and generate ATP is essential for the physiology, persistence and pathogenicity of Mycobacterium tuberculosis, which causes Tuberculosis. By employing a lead repurposing strategy, the malarial cytochrome bc1 inhibitor SCR0911 was tested against mycobacteria. Docking studies were carried out to reveal potential binding and to understand the binding interactions with the target, cytochrome bcc.

Not Open Access | Factors affecting the use of anti-malaria preventive measures among Taiwan immigrants returning to malaria-endemic regions

August 5, 2014 - 16:28 -- NOT Open Access
Author(s): 
Wen-Shin Hung, Susan C. Hu, Yu-Chen Hsu, Kwo-Liang Chen, Kou-Huang Chen, Mei-Ching Yu, Kow-Tong Chen
Reference: 
Travel Medicine and Infectious Disease, Volume 12, Issue 4, July–August 2014, Pages 370-377

The aim of this study was to investigate the predictors of anti-malaria preventive measures (AMPMs) among Taiwan immigrants returning to their country of origin using the Health Belief Model (HBM).

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